ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Artificial sweeteners linked to risk of weight gain, heart disease and other health issues

All About Ginkgo Biloba: Benefits of This Timeless Herbal Supplement

Yarrow Oil: Here's Why It Deserves a Place in Your First-Aid Kit

Vitamin D supplement use associated with lower risk of breast cancer

Carnitine deficiency suggested as contributor to autism

Lutein — An Important Nutrient for Eye and Brain Health

White Camphor Oil: The Purest Camphor Oil

Taurine: Facts About This Crucial Amino Acid

Lutein, found in leafy greens, may counter cognitive aging

Vitamin D3 Versus D2

 
Print Page
Email Article

How three common probiotic strains affect the expression of hundreds of genes in the gut lining to deliver health benefits - groundbreaking RNA analysis

  [ 20 votes ]   [ Discuss This Article ]
www.ProHealth.com • November 26, 2010


“Probiotic bacteria, specific representatives of bacterial species that are a common part of the human microbiota, are proposed to deliver health benefits to the consumer by modulation of intestinal function through largely unknown molecular mechanisms,” begins a research report by Peter van Baarlen et al., a team of gastroenterologists, nutritionists and genomics researchers in the Netherlands.

This unique study (a rigorous double-blind, placebo-controlled, cross-over trial) adds a great deal to the scientific understanding of those molecular mechanisms. Published in the prestigious Proceedings of the National Academy of Sciences of the USA,* the research involved:

• Feeding a small group of study subjects either a placebo or one of the three best-known probiotic species found in fermented dairy products such as yogurt - Lactobacillus acidophilusLactobacillus casei, and Lactobacillus rhamnosis. (The doses corresponded roughly with what a consumer would receive in a dairy product or supplement delivering live strains of the specific probiotic.) 

• Then actually collecting biopsy samples of the mucosal lining of the small intestine to identify any changes at the molecular/genetic expression level.

• And subjecting the RNA extracted from the biopsy specimens to whole genome expression array analysis.

What they found was a wealth of data on how the intestine “perceived” each probiotic species - how each “induced differential gene-regulatory networks and pathways in the intestinal mucosa.” In fact, the three probiotics influenced the expression of “several hundred up to thousands of genes,” in the gut lining.

The overall biological implication was that the human mucosa mounts “fast and specific responses on perception of each bacterial strain,” to the same extent in the mucosa of all volunteers. Overall, according to report’s section headings:

1. “Mucosal responses to L. acidophilus involve regulation of immune response, hormonal regulation of tissue growth and development, and ion homeostasis.” [Ion homeostasis is ability of the cell to adjust as needed to maintain a stable internal balance of essential ions.]

2. “Mucosal responses to L casei involve proliferation, Th1-Th2 balance, and hormonal regulation of blood pressure.” [When balanced, Th1 immune cells stimulate effective pathogen fighting and Th2 cells avoid destructive over-reaction.]

3. “Mucosal responses to L. rhamnosus involve wound healing, IFN response, and ion homeostasis.” [IFN (interferon) response is an action of the non-specific immune system which is induced quickly in viral infection before the specific immune system has time to activate.]

The researchers observe that these responses tend to coincide with historically and experimentally observed health benefits of these probiotics, such as studies associating consumption of L. rhamnosus with “prevention or relief of allergic symptoms.”

* To read the full text PDF of this free-access article – “Human mucosal in vivo transcriptome responses to three lactobacilli indicate how probiotics may modulate human cellular pathways,” PNAS Sep 7, 2010, go to http://www.pnas.org/content/early/2010/08/31/1000079107.long
____
Note: This information has not been evaluated by the FDA. It is general and should not be interpreted as preventing, diagnosing, treating or curing any condition, illness, or disease. It is very important that you make no change in your health care plan or health support regimen without researching and discussing it in collaboration with your professional healthcare team.




Post a Comment

Featured Products From the ProHealth Store
Ultra EPA  - Fish Oil Acidophilus Pearls Optimized Curcumin Longvida®


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Acidophilus Pearls Acidophilus Pearls
Guaranteed active cultures for better digestion
Jarro-Dophilus EPS Jarro-Dophilus EPS
Enhanced Probiotic System for Immune Health
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

The Curcumin Revolution: 'Golden' Ticket to Better Health The Curcumin Revolution: 'Golden' Ticket to Better Health
Help for Soreness and Swelling: What Do Silkworms Have to Do With It? Help for Soreness and Swelling: What Do Silkworms Have to Do With It?
Could a B-12 Deficiency Be Causing Your Symptoms? Could a B-12 Deficiency Be Causing Your Symptoms?
SAD? Coping with Seasonal Affective Disorder SAD? Coping with Seasonal Affective Disorder
Energy Breakthrough - One Fibromyalgia Patient’s Fortuitous Discovery Energy Breakthrough - One Fibromyalgia Patient’s Fortuitous Discovery

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map