ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

10 Fibro-Friendly Foods with a Bonus: Beautiful Skin

Fight Back! Win the War Being Waged Against Your Immune System

Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant...

Clary Sage Oil May Be Pricey, but Its Benefits Are Priceless

Component of red wine, grapes can help to reduce inflammation, study finds

Poly MVA: A Novel Therapy for Increasing Energy, Repairing DNA, and Promoting Overall Health

Pumpkin Pie Turmeric Breakfast Smoothie - Vegan + Gluten-Free

Vitamin D supplementation extends life in mouse model of Huntington's disease

What’s Fenugreek Good For?

Omega-3 fatty acid stops known trigger of lupus

Print Page
Email Article

WPI gene expression analysis identifies 'inflammatory signature' in XMRV-positive CFS patients

  [ 28 votes ]   [ 3 Comments ]
By VC Lombardi, JA Mikovits, et al. • • May 13, 2011

Article Title
Xenotropic Murine Leukemia Virus-related Virus-associated Chronic Fatigue Syndrome Reveals a Distinct Inflammatory Signature – Source: In Vivo, 25:307-314, 2011

By Vincent C Lombardi, Judith A Mikovits, et al.

[Note: The full text pdf of this forthcoming article by Whittemore-Peterson/U of Nevada researchers is freely accessible online at - with many thanks to Help ME Circle editor Jan van Roijen, who placed the study on MegaUpload for the benefit of the worldwide ME/CFS community. If you are not a member of this web hosting service, you will need to wait about 40 seconds to download using a ‘regular download’ button.]


Background: The recent identification of xenotropic murine leukemia virus-related virus (XMRV) in the blood of patients with chronic fatigue syndrome (CFS) establishes that a retrovirus may play a role in the pathology in this disease.

Knowledge of the immune response might lead to a better understanding of the role XMRV plays in this syndrome. Our objective was to investigate the cytokine and chemokine response in XMRV-associated CFS.

Materials and Methods: Using Luminex multi-analyte profiling technology, we measured cytokine and chemokine values in the plasma of XMRV-infected CFS patients and compared these data to those of healthy controls. Analysis was performed using the Gene Expression Pattern Analysis Suite and the Random Forest tree classification algorithm.

Results: This study identifies a signature of 10 cytokines and chemokines which correctly identifies XMRV/CFS patients with 93% specificity and 96% sensitivity.

Conclusion: These data show, for the first time, an immunological pattern associated with XMRV/CFS.

Source: In Vivo, 25;307-314 (2011). Lombardi VC, Hagen KS, Hunter KW, Diamond JW, Smith-Gagen J, Yang W, Mikovits JA. Whittemore Peterson Institute, University of Nevada; Triad Medical Center; Nevada Center for Health Statistics and Informatics, University of Nevada; University of Nevada Reno, Department of Microbiology and Immunology Applied Research Facility, Reno, Nevada, USA. [Email Dr. Vincent C Lombardi, WPI, U of Nevada –]

Post a Comment

Featured Products From the ProHealth Store
Vitamin D3 Extreme™ Ultra EPA  - Fish Oil Energy NADH™ 12.5mg

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments Post a Comment

What is the source of this article?
Posted by: janne00
May 14, 2011
Wouldn't it be more polite to mention the source of this *scoop*? It is copied from the email-bulletin *Help ME Circle; editor Jan van Roijen, who placed this study on MegaUpload. I always mention the source of every article in Help ME Circle. ~jan van roijen
Reply Reply

jan van roijen
Posted by: ProHealth
May 17, 2011
Thank you for letting us know about the omission. It has been corrected.


XMRV analysis
Posted by: Mbloomme
May 15, 2011
Hooray for WPI. You continue to be our best hope for answers to this horrible disease. Thank you for you continued efforts under pressure. Hopefully by next year tests will be recognized and covered by insurance and we can begin to use an accepted treatment protocol.
Reply Reply
Natural Pain Relief Supplements

Featured Products

FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Are You Obtaining the Proper Enzymes? Are You Obtaining the Proper Enzymes?
Help for Soreness and Swelling: What Do Silkworms Have to Do With It? Help for Soreness and Swelling: What Do Silkworms Have to Do With It?
Olea25 Olive Hydroxytyrosol Hits Astonishing 68,000+ ORAC Antioxidant Value Olea25 Olive Hydroxytyrosol Hits Astonishing 68,000+ ORAC Antioxidant Value
Running on Empty? Fuel Up with NADH Running on Empty? Fuel Up with NADH
Sleep Like a Baby in Nature's Cradle Sleep Like a Baby in Nature's Cradle

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map