ProHealth health Vitamin and Natural Supplement Store and Health
Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|
 
Print Page
Email Article

WPI gene expression analysis identifies 'inflammatory signature' in XMRV-positive CFS patients

  [ 28 votes ]   [ 3 Comments ]
By VC Lombardi, JA Mikovits, et al. • www.ProHealth.com • May 13, 2011

previous article next article

Article Title
Xenotropic Murine Leukemia Virus-related Virus-associated Chronic Fatigue Syndrome Reveals a Distinct Inflammatory Signature – Source: In Vivo, 25:307-314, 2011

By Vincent C Lombardi, Judith A Mikovits, et al.

[Note: The full text pdf of this forthcoming article by Whittemore-Peterson/U of Nevada researchers is freely accessible online at www.megaupload.com/?d=V980UCHY - with many thanks to Help ME Circle editor Jan van Roijen, who placed the study on MegaUpload for the benefit of the worldwide ME/CFS community. If you are not a member of this web hosting service, you will need to wait about 40 seconds to download using a ‘regular download’ button.]

Abstract

Background: The recent identification of xenotropic murine leukemia virus-related virus (XMRV) in the blood of patients with chronic fatigue syndrome (CFS) establishes that a retrovirus may play a role in the pathology in this disease.

Knowledge of the immune response might lead to a better understanding of the role XMRV plays in this syndrome. Our objective was to investigate the cytokine and chemokine response in XMRV-associated CFS.

Materials and Methods: Using Luminex multi-analyte profiling technology, we measured cytokine and chemokine values in the plasma of XMRV-infected CFS patients and compared these data to those of healthy controls. Analysis was performed using the Gene Expression Pattern Analysis Suite and the Random Forest tree classification algorithm.

Results: This study identifies a signature of 10 cytokines and chemokines which correctly identifies XMRV/CFS patients with 93% specificity and 96% sensitivity.

Conclusion: These data show, for the first time, an immunological pattern associated with XMRV/CFS.

Source: In Vivo, 25;307-314 (2011). Lombardi VC, Hagen KS, Hunter KW, Diamond JW, Smith-Gagen J, Yang W, Mikovits JA. Whittemore Peterson Institute, University of Nevada; Triad Medical Center; Nevada Center for Health Statistics and Informatics, University of Nevada; University of Nevada Reno, Department of Microbiology and Immunology Applied Research Facility, Reno, Nevada, USA. [Email Dr. Vincent C Lombardi, WPI, U of Nevada – vclombardi@gmail.com]



previous article
  Rating 4.5 (28 votes) next article




DISCUSS THIS ARTICLE   (3 existing comments) Post a Comment 


What is the source of this article?
Posted by: janne00
May 14, 2011
Wouldn't it be more polite to mention the source of this *scoop*? It is copied from the email-bulletin *Help ME Circle; editor Jan van Roijen, who placed this study on MegaUpload. I always mention the source of every article in Help ME Circle. ~jan van roijen
Reply Reply

 
jan van roijen
Posted by: ProHealth
May 17, 2011
Thank you for letting us know about the omission. It has been corrected.

 


XMRV analysis
Posted by: Mbloomme
May 15, 2011
Hooray for WPI. You continue to be our best hope for answers to this horrible disease. Thank you for you continued efforts under pressure. Hopefully by next year tests will be recognized and covered by insurance and we can begin to use an accepted treatment protocol.
Reply Reply
 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Your Next Order

Featured Products
Natural Resveratrol Natural Resveratrol
Powerful Antioxidant Support + Positive Anti-aging Effects
Omega 3-6-9 Omega 3-6-9
All three EFAs in one convenient form
FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid
Vitamin D3 5000 IU Vitamin D3 5000 IU
Give your body a boost with the sunshine vitamin
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Most Viewed Articles
What's the Hidden Cause Behind YOUR Fibromyalgia Flares? [more]

Pridgen Reports Fibromyalgia Antiviral Trial Results “Very Positive”: Predicts New Approach Will Be ... [more]

Massage Therapy Studies for Fibromyalgia Reviewed [more]

How to Limit or Minimize Your Fibromyalgia Flare [more]

Breaking News: FDA’s Sneak Attempt to Ban Another B Vitamin [more]

Mitochondrial Dysfunction, Post-Exertional Malaise and CFS/ME [more]

The Devil Is In The Details – A Herpes Simplex Virus Inquiry For Fibromyalgia and Chronic Fatigue Sy... [more]

Sensory Overload: Sources and Strategies [more]

Sympathetic Nervous System Dysfunction in FIbromyalgia and Overlapping Conditions [more]

Review of Nutritional Supplements Used for ME/CFS and FM [more]


FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing