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WPI gene expression analysis identifies 'inflammatory signature' in XMRV-positive CFS patients

  [ 28 votes ]   [ 3 Comments ]
By VC Lombardi, JA Mikovits, et al. • • May 13, 2011

Article Title
Xenotropic Murine Leukemia Virus-related Virus-associated Chronic Fatigue Syndrome Reveals a Distinct Inflammatory Signature – Source: In Vivo, 25:307-314, 2011

By Vincent C Lombardi, Judith A Mikovits, et al.

[Note: The full text pdf of this forthcoming article by Whittemore-Peterson/U of Nevada researchers is freely accessible online at - with many thanks to Help ME Circle editor Jan van Roijen, who placed the study on MegaUpload for the benefit of the worldwide ME/CFS community. If you are not a member of this web hosting service, you will need to wait about 40 seconds to download using a ‘regular download’ button.]


Background: The recent identification of xenotropic murine leukemia virus-related virus (XMRV) in the blood of patients with chronic fatigue syndrome (CFS) establishes that a retrovirus may play a role in the pathology in this disease.

Knowledge of the immune response might lead to a better understanding of the role XMRV plays in this syndrome. Our objective was to investigate the cytokine and chemokine response in XMRV-associated CFS.

Materials and Methods: Using Luminex multi-analyte profiling technology, we measured cytokine and chemokine values in the plasma of XMRV-infected CFS patients and compared these data to those of healthy controls. Analysis was performed using the Gene Expression Pattern Analysis Suite and the Random Forest tree classification algorithm.

Results: This study identifies a signature of 10 cytokines and chemokines which correctly identifies XMRV/CFS patients with 93% specificity and 96% sensitivity.

Conclusion: These data show, for the first time, an immunological pattern associated with XMRV/CFS.

Source: In Vivo, 25;307-314 (2011). Lombardi VC, Hagen KS, Hunter KW, Diamond JW, Smith-Gagen J, Yang W, Mikovits JA. Whittemore Peterson Institute, University of Nevada; Triad Medical Center; Nevada Center for Health Statistics and Informatics, University of Nevada; University of Nevada Reno, Department of Microbiology and Immunology Applied Research Facility, Reno, Nevada, USA. [Email Dr. Vincent C Lombardi, WPI, U of Nevada –]

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Article Comments Post a Comment

What is the source of this article?
Posted by: janne00
May 14, 2011
Wouldn't it be more polite to mention the source of this *scoop*? It is copied from the email-bulletin *Help ME Circle; editor Jan van Roijen, who placed this study on MegaUpload. I always mention the source of every article in Help ME Circle. ~jan van roijen
Reply Reply

jan van roijen
Posted by: ProHealth
May 17, 2011
Thank you for letting us know about the omission. It has been corrected.


XMRV analysis
Posted by: Mbloomme
May 15, 2011
Hooray for WPI. You continue to be our best hope for answers to this horrible disease. Thank you for you continued efforts under pressure. Hopefully by next year tests will be recognized and covered by insurance and we can begin to use an accepted treatment protocol.
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