Activate Now
 
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Patient Insights into the Design of Technology to Support a Strengths-Based Approach to Health Care.

Greater intake of dietary omega-3 fatty acids associated with lower risk of diabetic retinopathy

SURVEY: Weight Management & Chronic Illness

Japanese green tea consumers have reduced risk of dementia

Researchers find herpes strain in the nervous system

Do Nothing, Accomplish Everything! The Connection Between Breathing and Healing

Nature Heals

Choline: Why You Should Eat Your Egg Yolks and Take Krill

Calcium, vitamin D supplementation associated improved stroke recovery

Best Herbs to Help With Insomnia

 
Print Page
Email Article

Will healthy vitamin D level promote post-surgical healing?

  [ 15 votes ]   [ Discuss This Article ]
www.ProHealth.com • July 22, 2011


[Note: The study abstracted below was highlighted in a recent Q&A by Dr. John Cannell in the Vitamin D Council. A reader reported that his wife’s vitamin D level went from 70 ng/ml shortly before she was seriously injured in an auto accident to 32 shortly after, and wondered if there are any studies on vitamin D’s role in trauma response. Dr. Cannell responded by citing this recent study showing that “having a knee replacement [‘an inflammatory insult’] used up tremendous amounts of vitamin D.” The average reduction in serum D was 40% by day 2.]

Article:
The relation between acute changes in the systemic inflammatory response and plasma 25-hydroxyvitamin D concentrations after elective knee arthroplasty
– Source: American Journal of Clinical Nutrition, May 2011

By David Reid, et al.

Background:
Studies indicate that low plasma 25-hydroxyvitamin D [25(OH)D] is associated with a range of disease processes, many of which are inflammatory. However, other lipid-soluble vitamins decrease during the systemic inflammatory response, and this response may confound the interpretation of plasma 25(OH)D.

Objective:
The objective was to examine whether plasma 25(OH)D concentrations change during evolution of the systemic inflammatory response.

Design: Patients (n = 33) who underwent primary knee arthroplasty [replacement] had venous blood samples collected preoperatively and postoperatively (beginning 6-12 hours after surgery and on each morning for 5 days) for the measurement of 25(OH) D, vitamin D-binding protein, parathyroid hormone (PTH), calcium, C-reactive protein, and albumin. A final sample was collected at 3 months.

Results:
Preoperatively, most patients were 25(OH)D deficient (less than 50 nmol/L) and had secondary hyperparathyroidism (PTH > 5 pmol/L). [Note: Parathyroid hormone controls vitamin D levels in blood and bone. Secondary PTH is extra production of parathyroid hormone, seen when vitamin D levels are low causing calcium levels to be low.] Age, sex, body mass index, season, medical history, and medication use were not associated with significant differences in preoperative plasma 25(OH)D concentrations.

By day 2 there was a large increase in C-reactive protein concentrations (P < 0.001) [C-reactive protein rises when there is inflammation throughout the body], and a significant decrease in 25(OH)D of about 40% (P < 0.001).

C-reactive protein, 25(OH)D, and calculated free 25(OH)D had not returned to preoperative concentrations by 5 days postoperatively (all P < 0.001). At 3 months, 25(OH)D and free 25(OH)D remained significantly lower (20% and 30%, respectively; P < 0.01).

Conclusion: Plasma concentrations of 25(OH)D decrease after an inflammatory insult and therefore are unlikely to be a reliable measure of 25(OH)D status in subjects with evidence of a significant systemic inflammatory response.

Source: American Journal of Clinical Nutrition, May 2011;93(5):1006-11. PMID:21411617, by Reid D, Toole BJ, Knox S, Talwar D, Harten J, O'Reilly DS, Blackwell S, Kinsella J, McMillan DC, Wallace AM. Department of Anaesthesia, Faculty of Medicine, University of Glasgow, Royal Infirmary, Glasgow, UK.





Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength Energy NADH™ 12.5mg Vitamin D3 Extreme™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

Stop Bacteria With Nature's Antibiotics Stop Bacteria With Nature's Antibiotics
Magnesium: An Essential Supplement for ME/CFS Magnesium: An Essential Supplement for ME/CFS
Block Acid Reflux to Prevent Esophageal Problems! Block Acid Reflux to Prevent Esophageal Problems!
When a Good Night's Sleep Is Just a Daydream... When a Good Night's Sleep Is Just a Daydream...
Enhance Eyelashes Naturally Enhance Eyelashes Naturally

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE AND SAVE 15% NOW*
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map