ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Is Magnesium the Missing Link in Your Heart Healthy Routine?

More evidence for calorie restriction’s longevity effect

A Little Zinc Goes a Long Way

Supplementation with vitamin D associated with improved testosterone, erectile function among middle...

Vitamin D deficiency increases risk of chronic headache

VIDEO: The Best Brain Foods That Help Increase Your Memory!

Get the Most From Your Green Tea

Iron (And More) For Lasting, Natural Energy

Metabolic syndrome increases the need for vitamin E

Supplement combo improves bone density, mood, in postmenopausal women

 
Print Page
Email Article

Will healthy vitamin D level promote post-surgical healing?

  [ 15 votes ]   [ Discuss This Article ]
www.ProHealth.com • July 22, 2011


[Note: The study abstracted below was highlighted in a recent Q&A by Dr. John Cannell in the Vitamin D Council. A reader reported that his wife’s vitamin D level went from 70 ng/ml shortly before she was seriously injured in an auto accident to 32 shortly after, and wondered if there are any studies on vitamin D’s role in trauma response. Dr. Cannell responded by citing this recent study showing that “having a knee replacement [‘an inflammatory insult’] used up tremendous amounts of vitamin D.” The average reduction in serum D was 40% by day 2.]

Article:
The relation between acute changes in the systemic inflammatory response and plasma 25-hydroxyvitamin D concentrations after elective knee arthroplasty
– Source: American Journal of Clinical Nutrition, May 2011

By David Reid, et al.

Background:
Studies indicate that low plasma 25-hydroxyvitamin D [25(OH)D] is associated with a range of disease processes, many of which are inflammatory. However, other lipid-soluble vitamins decrease during the systemic inflammatory response, and this response may confound the interpretation of plasma 25(OH)D.

Objective:
The objective was to examine whether plasma 25(OH)D concentrations change during evolution of the systemic inflammatory response.

Design: Patients (n = 33) who underwent primary knee arthroplasty [replacement] had venous blood samples collected preoperatively and postoperatively (beginning 6-12 hours after surgery and on each morning for 5 days) for the measurement of 25(OH) D, vitamin D-binding protein, parathyroid hormone (PTH), calcium, C-reactive protein, and albumin. A final sample was collected at 3 months.

Results:
Preoperatively, most patients were 25(OH)D deficient (less than 50 nmol/L) and had secondary hyperparathyroidism (PTH > 5 pmol/L). [Note: Parathyroid hormone controls vitamin D levels in blood and bone. Secondary PTH is extra production of parathyroid hormone, seen when vitamin D levels are low causing calcium levels to be low.] Age, sex, body mass index, season, medical history, and medication use were not associated with significant differences in preoperative plasma 25(OH)D concentrations.

By day 2 there was a large increase in C-reactive protein concentrations (P < 0.001) [C-reactive protein rises when there is inflammation throughout the body], and a significant decrease in 25(OH)D of about 40% (P < 0.001).

C-reactive protein, 25(OH)D, and calculated free 25(OH)D had not returned to preoperative concentrations by 5 days postoperatively (all P < 0.001). At 3 months, 25(OH)D and free 25(OH)D remained significantly lower (20% and 30%, respectively; P < 0.01).

Conclusion: Plasma concentrations of 25(OH)D decrease after an inflammatory insult and therefore are unlikely to be a reliable measure of 25(OH)D status in subjects with evidence of a significant systemic inflammatory response.

Source: American Journal of Clinical Nutrition, May 2011;93(5):1006-11. PMID:21411617, by Reid D, Toole BJ, Knox S, Talwar D, Harten J, O'Reilly DS, Blackwell S, Kinsella J, McMillan DC, Wallace AM. Department of Anaesthesia, Faculty of Medicine, University of Glasgow, Royal Infirmary, Glasgow, UK.





Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength Optimized Curcumin Longvida® Energy NADH™ 12.5mg

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Probiotic Mint Promotes Healthy Gums & Teeth, Freshens Breath and Whitens Teeth Probiotic Mint Promotes Healthy Gums & Teeth, Freshens Breath and Whitens Teeth
Aching Muscles? Top 10 Nutrients to Take Back Your Life Aching Muscles? Top 10 Nutrients to Take Back Your Life
Stop Bacteria With Nature's Antibiotics Stop Bacteria With Nature's Antibiotics
The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol
Milk Thistle: Trusted Support for Health & Healing in a Toxic World Milk Thistle: Trusted Support for Health & Healing in a Toxic World

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map