Activate Now
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Brain White Matter Abnormalities in Female Interstitial Cystitis/Bladder Pain Syndrome: A MAPP Netwo...

How One LLND Treats Lyme disease and Co-infections Using Natural Medicine

Lyme Camp- A Unique Event for People with Lyme Disease

International Lyme and Associated Diseases Society Hosts Its Annual Scientific Conference in Ft. Lau...

Acupuncture reduces hot flashes in breast cancer survivors

Top 7 Nutrient-Dense Foods That Make Calorie Counting Obsolete

For veterans with Gulf War Illness, an explanation for the unexplainable symptoms

Magnificent Milk Thistle

DePaul Study Recruiting Participants

SURVEY: Has Your Illness Affected What You Eat?

Print Page
Email Article

Strong new evidence that MS risk affected by birth month, mom's vitamin D status

  [ 9 votes ]   [ Discuss This Article ] • November 20, 2012

The month of birth effect in multiple sclerosis: Systematic review, meta-analysis and effect of latitude
- Source: Journal of Neurology, Neurosurgery & Psychiatry, Nov 14, 2012. 

By Ruth Dobson, et al.

[Note: The free full text PDF of this article is available here. It reports on a first-time analysis of several large populations living at latitudes in the Northern Hemisphere where UV light is insufficient to produce vitamin D in an expectant mother's skin between October and March. Significantly greater risk of MS was found in people born at those latitudes during April and May (after the winter months) than for those born during October and November (after the summer months).]

Background: Month of birth has previously been described as a risk factor for multiple sclerosis (MS). This has been hypothesized to be related to maternal vitamin D levels during pregnancy, although conclusive evidence to support this is lacking.

To date, no large studies of latitudinal variation in the month of birth effect have been performed to advance this hypothesis.

Methods: Previously published data on month of birth from 151,978 MS patients were compared to expected birth rates. A linear regression model was used to assess the relationship between latitude and observed: expected birth ratio of MS patients for each month.

Results: Analysis of all reported data demonstrated a significant excess of MS risk in those born in April (observed-to-expected 1.05, p=0.05) and reduction in risk in those born in October (0.95, p=0.04) and November (0.92 p=0.01).

A conservative analysis of 78,488 patients revealed an excess MS risk in those born in April (1.07, p=0.002) and May (1.11, p=0.0006), and a reduced risk in those born in October (ratio 0.94, p=0.004) and November (0.88, p=0.0002). [A risk ratio of 1.0 would indicate no difference in risk; thus the risk ratio of 1.11 for May would indicate risk above expected of 11%, and the 0.88 ratio for November would indicate 12% less risk than expected for November births.]

A significant relationship between latitude and observed-to-expected ratio was demonstrated in December, and borderline significant relationships in May and August.

Conclusions: Month of birth has a significant effect on subsequent MS risk. This is likely to be due to ultraviolet light exposure and maternal vitamin D levels, as demonstrated by the relationship between risk and latitude.

Source: Journal of Neurology, Neurosurgery & Psychiatry, Nov 14, 2012. Dobson R, Giovannoni G, Ramagopalan S. Queen Mary University of London, Blizard Institute, Barts and the London School of Medicine and Dentistry, London; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford; Department of Clinical Neurology, John Radcliffe Hospital, Oxford, UK. [Email:]

Please Discuss This Article:   Post a Comment 

[ Be the first to comment on this article ]

Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Subscribe Now!
Receive up-to-date ME/CFS, Fibromyalgia & Lyme Disease treatment and research news
 Privacy Guaranteed  |  View Archives

Vitamins and Supplements

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

Aching Muscles? Top 10 Nutrients to Take Back Your Life Aching Muscles? Top 10 Nutrients to Take Back Your Life
Complete and Natural Menopause Relief Complete and Natural Menopause Relief
Natural Relief for Soreness, Pain and Swelling – Putting Out the Fire
Curcumin - a Golden Gift of Nature with Benefits Still Untold Curcumin - a Golden Gift of Nature with Benefits Still Untold
Why Berries Offer a Rainbow of Health Benefits Why Berries Offer a Rainbow of Health Benefits

What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Causes
Fibromyalgia Treatments
Fibromyalgia Diet
Fibromyalgia Medications
M.E. & CFS
What is M.E./CFS?
M.E./CFS Diagnosis
M.E./CFS Symptoms
M.E./CFS Causes
M.E./CFS Treatments
M.E./CFS Diet
M.E./CFS Medications
What is Lyme Disease?
Lyme Disease Diagnosis
Lyme Disease Symptoms
Lyme Disease Causes
Lyme Disease Treatments
Lyme Disease Diet
Lyme Disease Medications
M.E. & CFS
Lyme Disease
General Health
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing