ProHealth health Vitamin and Natural Supplement Store and Health
Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

Missing protein explains link between obesity, diabetes

Fish oil use associated with brain volume preservation

The Brain Boosting and Fatigue Fighting B-12

Genetic basis for distinct type of autism uncovered

Unsuspected aspect of immune regulation revealed: Role of B cells

IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders

Explaining 'Healthy' Obesity

Sinus Congestion and Sinusitis, Healing Naturally

In the gut, immunity is a two-way street

Omega 3 Fatty Acids Lessen Severity of Osteoarthritis in Mice

 
Print Page
Email Article

Lipid Peroxidation in Blood Mononuclear Cells Associated with Fibromyalgia Symptoms

  [ 1 vote ]   [ Discuss This Article ]
www.ProHealth.com • May 10, 2013


Editor's comment:  Many studies have shown high levels of oxidative stress in fibromyalgia patients.  Oxidative stress is usually determined by measuring lipid peroxidation (LPO) in blood plasma.  [Lipid peroxidation is the process in which free radicals “steal” electrons from the lipids in cell membranes, causing damage to the cells.]  However, there have been some discrepancies about the correlation between FM symptoms and LPO using this method.  This study was undertaken to determine whether measuring LPO in the cells themselves – specifically blood mononuclear cells – rather than in the plasma would result in a more consistent correlation between LPO and the clinical symptoms of FM.  [Blood mononuclear cells (BMCs) are any blood cells that have a round nucleus, including lymphocytes, monocytes and macrophages.  BMCs are a critical component of the immune system.] 

Note: You may read the full text of this article free HERE.

Clinical Symptoms in Fibromyalgia Are Better Associated to Lipid Peroxidation Levels in Blood Mononuclear Cells Rather than in Plasma

By Mario D. Cordero, et al.
 
Abstract:

Background: We examined lipid peroxidation (LPO) in blood mononuclear cells (BMCs) and plasma, as a marker of oxidative damage, and its association to clinical symptoms in Fibromyalgia (FM) patients.

Methods: We conducted a case–control and correlational study comparing 65 patients and 45 healthy controls. Clinical parameters were evaluated using the Fibromyalgia Impact Questionnaire (FIQ), visual analogues scales (VAS), and the Beck Depression Inventory (BDI). Oxidative stress was determined by measuring LPO in BMCs and plasma.

Results: We found increased LPO levels in BMCs and plasma from FM patients as compared to normal control (P<0.001).

  • A significant correlation between LPO in BMCs and clinical parameters was observed (r = 0.584, P<0.001 for VAS; r = 0.823, P<0.001 for FIQ total score; and r = 0.875, P<0.01 for depression in the BDI).

  • We also found a positive correlation between LPO in plasma and clinical symptoms (r = 0.452, P<0.001 for VAS; r = 0.578, P<0.001 for FIQ total score; and r = 0.579, P<0.001 for depression in the BDI).

  • Partial correlation analysis controlling for age and BMI, and sex, showed that both LPO in cells and plasma were independently associated to clinical symptoms.

  • However, LPO in cells, but not LPO in plasma, was independently associated to clinical symptoms when controlling for depression (BDI scores).

Discussion: The results of this study suggest a role for oxidative stress in the pathophysiology of fibromyalgia and that LPO in BMCs rather than LPO in plasma is better associated to clinical symptoms in FM.

Source:
PloS ONE, October 28, 2011. By Mario D. Cordero, Elísabet Alcocer-Gómez, Francisco J. Cano-García, Manuel De Miguel, Angel M. Carrión, Plácido Navas and José A. Sánchez Alcázar. Hospital Vall d?Hebron, Spain.





Discuss This Article Post a Comment 




[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Featured Products

Vitamin D3 Extreme™ by ProHealth Vitamin D3 Extreme™ by ProHealth
50,000 IU Vitamin D3 - Prescription Strength
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Optimized Curcumin Longvida® by ProHealth Optimized Curcumin Longvida® by ProHealth
Supports Cognition, Memory & Overall Health

Natural Remedies

A Breakthrough for Mitochondrial Dysfunction A Breakthrough for Mitochondrial Dysfunction
Protecting Our Eyes Against Time-Induced Damage Protecting Our Eyes Against Time-Induced Damage
Shoo Pain, Don't Bother Me - Top 10 Nutrients to Take Back Your Life Shoo Pain, Don't Bother Me - Top 10 Nutrients to Take Back Your Life
The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health
Broad Spectrum Protection Against Brain Aging Broad Spectrum Protection Against Brain Aging

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing