ProHealth health Vitamin and Natural Supplement Store and Health
Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

Missing protein explains link between obesity, diabetes

The Brain Boosting and Fatigue Fighting B-12

Genetic basis for distinct type of autism uncovered

Unsuspected aspect of immune regulation revealed: Role of B cells

IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders

Sinus Congestion and Sinusitis, Healing Naturally

Explaining 'Healthy' Obesity

New Science Destroys the Saturated Fat Myth

Ginger's Many Evidence-Based Health Benefits Revealed

Omega 3 Fatty Acids Lessen Severity of Osteoarthritis in Mice

 
Print Page
Email Article

“Flowers” in the blood: A novel paired erythrocyte arrangement in a patient with chronic fatigue syndrome following infectious mononucleosis

  [ 10 votes ]   [ 1 Comment ]
By Carrie E Burdzinski • www.ProHealth.com • July 11, 2014


Editor's Comment: Dr. Leslie O. Simpson, a reseacher from New Zealand, has found abnormal red blood cells in patients with ME/CFS (1989, 1993,  1997, 2002). Dr. Simpson maintained that the presence of nondiscocyte red blood cells demonstrated that ME was an organic disease, and that the abnormal RBCs might be used for diagnosis. He also suggested that treatment could be aimed at correcting impaired capillary flow resulting from nondiscocyte cells. Abnormal RBCs are found in a number of disease processes.

By Carrie E Burdzinski

Abstract

Introduction: Chronic fatigue syndrome is a debilitating condition characterized by persistent fatigue, post-exertional malaise, myalgia, arthralgia, lymph node tenderness, impaired memory and concentration, autonomic irregularities, and other specific symptoms affecting multiple body systems.

Diverse hypotheses have been investigated to ascertain the disease etiology. Some of these include metabolic and mitochondrial deficiencies, exposure to environmental toxins, dysautonomia associated with orthostatic intolerance, autoimmune reactions, neuroendocrine aberrations, and chronic viral infections. However, a consistently observed biomarker for chronic fatigue has not been identified. A comprehensive, standardized strategy for accurate diagnosis and successful treatment remains elusive.

Case Report: A 28-year-old Caucasian female presented with chronic fatigue persisting for nine months following infectious mononucleosis.
Laboratory evaluation excluded classic causes of fatigue. Peripheral blood smear examination revealed numerous pairs of unusual nondiscocytic C-shaped erythrocytes, coupled in perpendicular crosses resembling four-petalled flowers. The presence of the erythrocyte pairs abated with the patient’s recovery from chronic fatigue syndrome over a 24-month period. This erythrocyte arrangement has not been reported elsewhere in medical literature.

Conclusion: A novel erythrocyte “flower” formation was identified in a patient with chronic fatigue syndrome. The presence of this arrangement paralleled the course of the illness and was no longer observed upon recovery. The physiological relevance of the structure remains a subject for future research. Several hypotheses are suggested, including enhanced membrane deformability resulting from elevated catecholamine levels, and immunemediated agglutination, possibly stemming from viral infection.

Source: Burdzinski, Carrie E “Flowers” in the blood: A novel paired erythrocyte arrangement in a patient with chronic fatigue synd. rome following infectious mononucleosis. Int J Case Rep Images 2014;():*****.




Discuss This Article Post a Comment 


Fascinating!!!
Posted by: IanH
Jul 11, 2014
What a great confirmation of Simpson's earlier work.
Now we can see why the A-V shunts are activating and developing. Oversized erythrocytes and agglutinated erythrocytes cannot penetrate the capillary bed. They then bank up. Such "back-pressure" activates the A-V shunt or where there is no shunt one develops. The more the shunts are activated the less perfusion of muscle, skin, peripheral nerve and possibly even internal organs and glands.

As a consequence we have poor oxygenation, poor ROS and NOS clearance and reduced mitochondrial performance because of lowered mitochondrial membrane potential.

Things are starting to add-up.
Now we need to show why/how the immune system (infection) causes the change in erythrocyte behaviour and morphology.
Reply Reply
 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Your Next Order

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Optimized Curcumin Longvida® by ProHealth Optimized Curcumin Longvida® by ProHealth
Supports Cognition, Memory & Overall Health
Vitamin D3 Extreme™ by ProHealth Vitamin D3 Extreme™ by ProHealth
50,000 IU Vitamin D3 - Prescription Strength
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid

Natural Remedies

Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10 Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10
Green Coffee Extract: Unique Obesity Intervention Green Coffee Extract: Unique Obesity Intervention
A Breakthrough for Mitochondrial Dysfunction A Breakthrough for Mitochondrial Dysfunction
The Brain Boosting and Fatigue Fighting B-12 The Brain Boosting and Fatigue Fighting B-12
Reversing Neurodegeneration with a New Magnesium Compound Reversing Neurodegeneration with a New Magnesium Compound

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing