Activate Now
 
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

How Your Gut Microbiome Influences Your Mental and Physical Health

High dose vitamin D3 supplementation lowers inflammatory T cells in multiple sclerosis patients

Chocolate's Potential Health Benefits – and its Effect on Chronic Fatigue Syndrome Patients

Repair Damaged Mitochondria and Reduce Fatigue Up to 45%

Essential Oils - How and Where to Use Them

The Link Between Vitamin C And Optimal Immunity

What's So Great About Grape Seed?

Why Does Your Nose Run When It's Cold Outside?

Study suggests that what you eat can influence how you sleep

SURVEY: What Is Your Diagnosis?

 
Print Page
Email Article

“Flowers” in the blood: A novel paired erythrocyte arrangement in a patient with chronic fatigue syndrome following infectious mononucleosis

  [ 11 votes ]   [ 1 Comment ]
By Carrie E Burdzinski • www.ProHealth.com • July 11, 2014


Editor's Comment: Dr. Leslie O. Simpson, a reseacher from New Zealand, has found abnormal red blood cells in patients with ME/CFS (1989, 1993,  1997, 2002). Dr. Simpson maintained that the presence of nondiscocyte red blood cells demonstrated that ME was an organic disease, and that the abnormal RBCs might be used for diagnosis. He also suggested that treatment could be aimed at correcting impaired capillary flow resulting from nondiscocyte cells. Abnormal RBCs are found in a number of disease processes.

By Carrie E Burdzinski

Abstract

Introduction: Chronic fatigue syndrome is a debilitating condition characterized by persistent fatigue, post-exertional malaise, myalgia, arthralgia, lymph node tenderness, impaired memory and concentration, autonomic irregularities, and other specific symptoms affecting multiple body systems.

Diverse hypotheses have been investigated to ascertain the disease etiology. Some of these include metabolic and mitochondrial deficiencies, exposure to environmental toxins, dysautonomia associated with orthostatic intolerance, autoimmune reactions, neuroendocrine aberrations, and chronic viral infections. However, a consistently observed biomarker for chronic fatigue has not been identified. A comprehensive, standardized strategy for accurate diagnosis and successful treatment remains elusive.

Case Report: A 28-year-old Caucasian female presented with chronic fatigue persisting for nine months following infectious mononucleosis.
Laboratory evaluation excluded classic causes of fatigue. Peripheral blood smear examination revealed numerous pairs of unusual nondiscocytic C-shaped erythrocytes, coupled in perpendicular crosses resembling four-petalled flowers. The presence of the erythrocyte pairs abated with the patient’s recovery from chronic fatigue syndrome over a 24-month period. This erythrocyte arrangement has not been reported elsewhere in medical literature.

Conclusion: A novel erythrocyte “flower” formation was identified in a patient with chronic fatigue syndrome. The presence of this arrangement paralleled the course of the illness and was no longer observed upon recovery. The physiological relevance of the structure remains a subject for future research. Several hypotheses are suggested, including enhanced membrane deformability resulting from elevated catecholamine levels, and immunemediated agglutination, possibly stemming from viral infection.

Source: Burdzinski, Carrie E “Flowers” in the blood: A novel paired erythrocyte arrangement in a patient with chronic fatigue synd. rome following infectious mononucleosis. Int J Case Rep Images 2014;():*****.




Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Ultra EPA  - Fish Oil Energy NADH™ 12.5mg

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments Post a Comment

Fascinating!!!
Posted by: IanH
Jul 11, 2014
What a great confirmation of Simpson's earlier work.
Now we can see why the A-V shunts are activating and developing. Oversized erythrocytes and agglutinated erythrocytes cannot penetrate the capillary bed. They then bank up. Such "back-pressure" activates the A-V shunt or where there is no shunt one develops. The more the shunts are activated the less perfusion of muscle, skin, peripheral nerve and possibly even internal organs and glands.

As a consequence we have poor oxygenation, poor ROS and NOS clearance and reduced mitochondrial performance because of lowered mitochondrial membrane potential.

Things are starting to add-up.
Now we need to show why/how the immune system (infection) causes the change in erythrocyte behaviour and morphology.
Reply Reply
 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS, Fibromyalgia & Lyme Disease treatment and research news
 Privacy Guaranteed  |  View Archives

How Glutathione Can Save Your Life

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

Strontium - The Missing Mineral for Strong Bones Strontium - The Missing Mineral for Strong Bones
Probiotic Mint Promotes Healthy Gums & Teeth, Freshens Breath and Whitens Teeth Probiotic Mint Promotes Healthy Gums & Teeth, Freshens Breath and Whitens Teeth
Green Coffee Extract: Unique Obesity Intervention Green Coffee Extract: Unique Obesity Intervention
Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed
Block food Cravings At Their Molecular Root Block food Cravings At Their Molecular Root

FIBROMYALGIA
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Causes
Fibromyalgia Treatments
Fibromyalgia Diet
Fibromyalgia Medications
M.E. & CFS
What is M.E./CFS?
M.E./CFS Diagnosis
M.E./CFS Symptoms
M.E./CFS Causes
M.E./CFS Treatments
M.E./CFS Diet
M.E./CFS Medications
LYME DISEASE
What is Lyme Disease?
Lyme Disease Diagnosis
Lyme Disease Symptoms
Lyme Disease Causes
Lyme Disease Treatments
Lyme Disease Diet
Lyme Disease Medications
FORUMS
Fibromyalgia
M.E. & CFS
Lyme Disease
General Health
WHOLESALE
AFFILIATES GUARANTEE
PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing