ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

SURVEY: Weight Management & Chronic Illness

Japanese green tea consumers have reduced risk of dementia

Meet the ProHealth Editors

Do Nothing, Accomplish Everything! The Connection Between Breathing and Healing

Best Herbs to Help With Insomnia

Choline: Why You Should Eat Your Egg Yolks and Take Krill

Calcium, vitamin D supplementation associated improved stroke recovery

Acupressure reduced fatigue in breast cancer survivors

Fight Back! Win the War Being Waged Against Your Immune System

More positive evidence for melatonin in breast cancer battle

 
Print Page
Email Article

CWRU Researcher Finds Nicotine Inhibits Alzheimer's Disease

  [ Not Yet Rated ]   [ Discuss This Article ]
By Press Release by Case Western Reserve University • www.ProHealth.com • November 4, 1996


(CLEVELAND)-- No cure exists for Alzheimer's Disease (AD), but a group of researchers at Case Western Reserve University has found in test tube studies that nicotine inhibits the formation of amyloid plaque -- the toxic substance found in the brains of Alzheimer's patients and suspected as the cause of the devastating dementia of memory loss.

The research work was conducted in the laboratory of Michael Zagorski, assistant professor in the Department of Chemistry. The team reported findings in the October 22 issue of "Biochemistry," a journal of the American Chemical Society.

The amyloid plaques are abundant in AD brains, and the major component of the plaques is the beta-peptide. The beta-peptide is normally found in everyone's blood plasma and other fluids. However, under certain environmental changes, the beta-peptides undergo a transformation from a soluble form (alpha-helix) to one that is toxic to nerve cells (beta-sheet). Both are elementary structures found in strings of amino acids that make up proteins and peptides. A major goal of research is to find ways to prevent the toxic beta-sheets from forming.

Although cigarette smoking is hazardous to human health, previous studies in the 1990s demonstrated an inverse relationship between smoking and AD.
These findings came shortly after Zagorski published a paper in "Science" in 1992 with Colin Barrow from New Zealand on the effects of how acidity levels below pH 7 caused the toxic changes in beta-peptide structure, accelerating the transformation of the beta-peptide into amyloid plaque-like material.
Zagorski speculated that an analogous lowering of the blood pH, which may happen from over-exertion and a decrease of oxygen to the brain, may be partly responsible for amyloid plaque formation in AD brains. However, this proposition remains to be tested, he said. Sensing a possible link in the area of his research to the potential of nicotine for interrupting the helix to beta-sheet formation, Zagorski began new research studies with nicotine.

Working under Zagorski's supervision, Arthur Salomon (who at the time was an undergraduate student and now is a graduate student at Stanford University) performed the experiments that showed nicotine inhibits production of the toxic beta-sheet structures and the accompanying formation of amyloid plaques.

Cotinine, a substance formed through metabolism of nicotine in humans, also slowed down the transformation, but it was less effective than nicotine.
Graduate students also participating in the research included Shu-chuan Jao, Keith Marcinowski, and Haiyan Shao. Robert Friedland from the Department of Neurology in CWRU's School of Medicine also contributed to the study.
The researchers are currently obtaining a three-dimensional molecular model of nicotine when it is bound to pre-transformation structure of the beta-peptide.

"This model may later facilitate the development of nicotine-like compounds that could prevent or slow down amyloid formation in AD patients," said Zagorski. He also stresses that nicotine in tobacco is hazardous to human health, and that cigarette smoking should not be considered as a method to delay or prevent the onset of AD.

Direct research funding came from an Alzheimer's Association Faculty Scholars Award, the American Health Assistance Foundation, the National Institute on Aging, the Ohio and New York affiliates of American Federation for Aging Research, Suntory Institute of Bioorganic Research, Gliatech Incorporated, and the Ohio Board of Regents.

Indirect funding came through a grant from Philip Morris U.S.A. to Friedland.

Source: Case Western Reserve Univiversity Press Release: November 4, 1996

Contact: Susan Griffith, sbg4@po.cwru.edu, 1-800-368-CWRU



Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg Ultra EPA  - Fish Oil Mitochondria Ignite™ with NT Factor®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Everything You Always Wanted to Know About Sleep But Were Too Tired to Ask Everything You Always Wanted to Know About Sleep But Were Too Tired to Ask
Physically and Mentally Exhausted? How to Restore Energy at Its Source Physically and Mentally Exhausted? How to Restore Energy at Its Source
Energy Breakthrough - One Fibromyalgia Patient’s Fortuitous Discovery Energy Breakthrough - One Fibromyalgia Patient’s Fortuitous Discovery
Block food Cravings At Their Molecular Root Block food Cravings At Their Molecular Root
Cocoa's Polyphenol Riches - All the Health Benefits without the Sugar, Calories or Guilt Cocoa's Polyphenol Riches - All the Health Benefits without the Sugar, Calories or Guilt

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE AND SAVE 15% NOW*
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map