Grape Consumption Extends Lifespan and Modulates Gene Expression in Mice
The equivalent of two cups of grapes per day extended lifespan, improved liver health, and modulated gene expression in mice on a high-fat diet.
The authors estimate that the change observed in the study would correspond to an additional 4-5 human years.
Fourteen genes responsible for the metabolism of fatty acids were upregulated, as well as genes related to antioxidant pathways and liver health.
Recent studies released by Dr. John Pezzuto and his team from Western New England University show “astonishing” effects of grape consumption and “remarkable” impacts on health and on lifespans.
Published in the journal Foods, one study showed that adding grapes in an amount equal to just under two cups of grapes per day to a high-fat diet, typically consumed in western countries, yielded reductions in fatty liver and extended lifespans. Noting that these studies add an entirely new dimension to the old saying ‘you are what you eat,’ Pezzuto, who has authored over 600 scientific studies, said that the work with grapes showed actual changes in genetic expression. “That is truly remarkable."
Adding grapes to a high-fat diet also increased levels of antioxidant genes and delayed natural death. Acknowledging that it is not an exact science to translate years of lifespan from a mouse to a human, Pezzuto said that his best estimate is the change observed in the study would correspond to an additional 4-5 years in the life of a human.
Another study by Dr. Pezzuto and his team published in the journal Antioxidants, reported that grape consumption altered gene expression in the brain and had positive effects on behavior and cognition that were impaired by a high-fat diet. A third study, published by a team led by Dr. Jeffrey Idle in the journal Food & Nutrition, showed that in addition to changes in genetic expression, grapes also change the metabolism.
The California Table Grape Commission provided the grapes used in the studies as well as partial support. For more information on these studies, please follow the link: https://www1.wne.edu/news/2022/08/effects-of-dietary-grapes-john-pezzuto.cfm
 Studies were done in mice.