Longevity Articles

A Guide to Understanding Calcium AKG

A Guide to Understanding Calcium AKG

What is Calcium AKG?

Around age 40, our bodies begin to produce less alpha ketoglutarate (AKG), resulting in nearly a 90% reduction in alpha ketoglutarate levels at age 80 compared to age 40. AKG is a compound naturally produced in the body that provides fuel for the mitochondria, our “powerhouse cells”. It plays a key role in supporting energy production as well as bone and muscle health. 

A decrease in AKG levels may lead to different age-related signs related to bone health, heart health, and energy levels.

AKG cannot be obtained from food. To create a supplemental form, AKG is attached to a calcium molecule through scientific processes. The supplemental form is known as calcium alpha-ketoglutarate (Ca-AKG) and has been studied for its longevity benefits. 

Supplementing with Ca-AKG offers numerous benefits for combatting age-related decline in cells, tissues, and quality of life.

Who Should Take Calcium AKG 

Individuals looking to improve markers of longevity and reverse biological age may benefit from adding calcium AKG to their longevity protocol. 

Research-Supported Benefits of Calcium AKG 

Supports Bone Health

As you age, bone density naturally decreases which increases the risk of fractures. Bone health is a key indicator of longevity. A 2020 study conducted with mice found that AKG administration resulted in increases in bone volume, thickness, mass and bone mineral density. 

bones and Calcium AKG

Supports Heart Health

Maintaining a healthy heart is vital in promoting a healthy lifespan. Supplementation with calcium AKG in mice has been shown to improve antioxidant status and support blood vessel elasticity, key markers associated with good heart health.

Supports Cell Health

As we age, longevity decreases in part due to a decrease in the process known as autophagy. Autophagy is our body’s cellular recycling process that helps clear out damaged and dysfunctional cells. 

Low levels of autophagy can cause aging and disease due to a buildup of these damaged cells. Ca-AKG has been found to extend lifespan in animals by increasing autophagy. One study found that AKG supplementation extended the lifespan of worms by ~50%!. Another study found that Ca-AKG extended the lifespan and healthspan of mice by 12% and 41% respectively.

May Reverse Biological Aging

Biological aging is cellular aging due to an accumulation of damage within the body. Unlike chronological aging which assesses your age based on how many years you’ve been alive, biological age assesses cellular health and may even be reversible.

In a retrospective analysis involving human subjects, participants taking 1,000mg of calcium AKG for an average of 7 months experienced an 8-year reversal in biological aging as measured by DNA methylation clocks (biological age testing). 

How to Take Calcium AKG

For longevity purposes, it’s recommended to take 1,000 mg in the morning with or without food. 

How to Know if Calcium AKG is Effective

Using an at-home biological age testing kit could help. As an experiment, you could take an at-home biological age test before supplementing with calcium AKG. Biological age tests, also known as methylation clocks, provide an estimate of cellular age based on DNA saliva testing. These tests are a fun way to get an idea of how you’re aging on a cellular level. 

Take another biological age test in about 6-10 months to see how the calcium AKG impacted your biological age.

looking at calcium akg supplement

Warnings and Interactions for Calcium AKG

While research is ongoing, initial research does not show significant concerns with interactions between calcium AKG and other supplements/medications.

Research shows that there are no significant adverse effects when taken at 4.5 grams for as long as 3 years.

It is recommended that you consult with your doctor before taking calcium AKG or any other supplement. For additional calcium AKG questions and personalized product recommendations, connect with a Nutrition Advisor through the free nutrition consultation service. 



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