This research has important implications for understanding the underlying factors driving aging and Alzheimer’s disease, and for implementing biologically defined and personalized medical care. 

Understanding the changes to protein levels in plasma that precede the onset of dementia could yield insights into disease biology and highlight new biomarkers and avenues for intervention.

The central nervous system — the brain and spinal cord — is prone to decline as we age; the accumulation of immune CD8 T-Cells is a primary culprit that leads to neuronal damage.

Exposure to air pollution, even short-term, can impede mental performance; these adverse effects were lessened in people taking non-steroidal anti-inflammatory drugs (NSAIDs), like aspirin or ibuprofen.