The compound procyanidin C1 in grape seed extract increases the healthspan and lifespan of mice through its senolytic activity, meaning it eliminates zombie-like senescent cells that contribute to aging.

Maintaining mentally challenging employment benefits cognition and wellbeing among older adults — especially when combined with social connectedness and a sense of purpose. 

Fasting-mimicking diets boost health and longevity in mice, reversing the effects of an unhealthy diet. Plus, researchers find that caloric restriction does not provide the same benefits as prolonged fasting. 

Fisetin’s ability to modulate pathways associated with brain and immune health, as well as its senolytic potential, strongly suggest that it would be worthwhile to pursue its effects in supporting healthy aging in humans.