A 12-year study of older adults shows how the plant-based polyphenols found in coffee, cacao, mushrooms, and red wine boost brain health and support cognition.

The compound procyanidin C1 in grape seed extract increases the healthspan and lifespan of mice through its senolytic activity, meaning it eliminates zombie-like senescent cells that contribute to aging.

Using a novel algorithm, researchers find that a pro-inflammatory diet increases the risk of frailty by 16% — and that the least inflammatory diets fight this decline in physical function. 

NMN supplementation promoted healthier aging in mice by altering the metabolism of amino acids, nucleotides, and NAD+, in addition to lengthening chromosomal ends called telomeres.