Aging increases the risk of lung fibrotic disorders; the sirtuin SIRT3 is reduced in these disorders. Boosting SIRT3 reversed the cell dysfunction that causes lung fibrosis, improving the health of aged mice.

More than one third of genetic variants that increase the risk of coronary artery disease are located in the liver, regulating the expression of genes related to glucose and cholesterol metabolism.

New compound eliminates the degeneration of upper motor neurons that contribute to ALS (Lou Gehrig's disease). The compound, NU-9, reduces protein misfolding and clumping.

The gene FOXO3 is associated with longevity and humans living past age 100. New research finds that FOXO3 protects the brain's stem cells from stress-induced damage, preserving its ability to regenerate.