Longevity Articles

A Triumphant Trifecta: A Guide to NMN Pro Complete

A youthful woman pouring a scoop of NMN Pro Complete powder into a shaker jar

If you search for supplements that support healthy aging, you’re bound to find a seemingly endless list. So, how in the world is anyone supposed to choose from this sea of supplements? 

Look no further than the vital molecule nicotinamide adenine dinucleotide (NAD+) and how it’s metabolized. NAD+ is present in every living animal cell, where it is essential for cellular survival, functionality, and energy metabolism.


The Important Role of NAD+ Metabolism in Aging and Longevity 

There is some evidence that as people age, their NAD+ levels begin to decline, which affects how efficiently NAD+-dependent enzymes function. This leads to several problems, starting with the damage to DNA, which causes oxidative stress and, in the end, stops cells from working.

For example, the sirtuin enzyme family, which is also called the "longevity genes," needs NAD+ to work and is responsible for many important cellular processes. At the cellular level, sirtuin activation is linked to a healthy metabolism and the integrity of DNA. Also, sirtuins affect how the immune system, heart, and brain work, how healthy they are, and how fast they age. 

These reasons make increasing NAD+ levels and improving the molecule's utilization by cells a very promising objective for healthy aging. And that is precisely what ProHealth's NMN Pro Complete was made to do: take advantage of NAD+ biology to encourage healthy aging.

The Contents of NMN Pro Complete

Three ingredients that have all been shown to support wellness and aging makeup this well-rounded supplement:

  • Nicotinamide mononucleotide (NMN): There are a few different pathways by which NAD+ can be made, but nicotinamide mononucleotide (NMN) is one of the most straightforward ones. It has been demonstrated that NMN, which can be converted directly into NAD+, aids in restoring and elevating the concentrations and, ultimately, metabolism of this crucial molecule.
  • Resveratrol: A plant-based substance called trans-resveratrol works as a sirtuin activator. Natural phytoalexins, like those found in red grapes, peanuts, and berries, are made by plant tissues when interacting with parasites. These substances stop the growth of the parasite in question. 
  • Trimethylglycine (TMG): this methyl donor, commonly referred to as betaine anhydrous (or betaine for short), works in conjunction with NMN supplements by assisting in replenishing the body's methyl pool. NAD+ is changed into nicotinamide, which is then mostly changed into methylnicotinamide by adding a methyl group. If the methyl group originates from your body's methyl pool, that pool is put under stress because it is involved in several processes affecting your heart, brain, reproductive system, liver, and metabolic health. 
NMN Pro Complete capsules on golden spoons with a pink background.

    How Can NMN Pro Complete Aid in Healthy Aging?

    Animal studies have shown that NMN has many health benefits, such as helping to keep mitochondria healthy, which is important for the proper functioning and aging of many organ systems, such as the circulatory, nervous, and cardiovascular systems. A recent study on NMN revealed that the NAD+ precursor decreased cell senescence, an aging process in which cells lock up and cease growing and dividing (Wang et al., 2022). Human research has shown that NMN can increase levels of NAD+ (Irie et al., 2020; Yoshino et al. 2021), and the NMN used in NMN Pro complete (Uthever® NMN) demonstrated some of the best responses of NAD+ (Huang et al., 2022). Furthermore, a clinical study found that NMN supplementation seems to increase NAD+ metabolism and has some health benefits, such as significantly reduced levels of blood fats (Kimura et al,. 2022).

    Trans-resveratrol is mostly known for its antioxidant properties. However, clinical research (Samsami-Kor et al., 2015) shows it supports healthy blood sugar metabolism, gut immune responses, and brain blood flow. Recent clinical research (Almeida Santos et al., 2022) showed that resveratrol supplementation reduced inflammation, a process that is becoming more and more linked to getting older. Resveratrol may have an effect to delay and modulate cognitive brain aging processes and decrease the occurrence of its effects on the brain (Terracina et al., 2022). A recent review summarized that resveratrol exerts a number of favorable effects on the heart and blood vessels as well as longevity regulation, energy metabolism, stress resistance, the body’s clock (circadian rhythms), and microbiota composition (Cheng et al., 2020).

    TMG supports the body's metabolization of the protein-building block homocysteine. Problems with cardiovascular health are linked to higher homocysteine levels. Studies on rats indicate that TMG might aid in preventing dangerous fatty liver deposits. In human cells, TMG may counteract bone and muscle aging (Villa et al., 2017). A clinical trial recently showed that increases in dietary TMG intake were longitudinally related to improvements in cardiometabolic parameters (Díez-Ricote et al. 2022). Another showed that dietary TMG intake is associated with protection against age-related loss of skeletal muscle mass (Long et al., 2021). 

    What NMN Pro Complete Dose Should I Take?

    When you take NMN Pro Complete, you have the optimized ratio of each in a single handy serving. You will receive 1,000 mg of NMN, 1,000 mg of trans-resveratrol, and 500 mg of TMG in one scoop of NMN Pro Complete, which is the amount recommended by the top longevity specialists in the world. 

    How Can I Assess the Quality of My NMN Pro Complete?

    Each batch of NMN Pro Complete undergoes laboratory inspection by a professional analytical laboratory service that performs chemical and microbiological testing on nutraceuticals and dietary supplements following current Good Manufacturing Practice (cGMP) regulation and NSF, FDA, and ISO guidelines and standards. The Certificate of Analysis is available to view on prohealth.com. 

    Three youthful and active adults smiling while outdoors

    NMN Pro Complete in A Nutshell 

    What makes the NMN in NMN Pro Complete so special, is it's the first NMN on the market that has been clinically proven to increase NAD+ levels by 38% and reverse biological age by 12 years. The combination of NMN, TMG and Trans-Resveratrol is a unique combination of incredibly high quality, purity, and potency. 


    Garrigue P, Mounien L, Champion S, Mouhajir Y, Pechere L, Guillet B, Landrier JF, Seree E. J Nutr Biochem. 2021 Nov;97:108786.

    Irie J, Inagaki E, Fujita M, Nakaya H, Mitsuishi M, Yamaguchi S, Yamashita K, Shigaki S, Ono T, Yukioka H, Okano H, Nabeshima YI, Imai SI, Yasui M, Tsubota K, Itoh H. Endocr J. 2020 Feb 28;67(2):153-160. 

    Rabbani N, Xue M, Weickert MO, Thornalley PJ. Nutrients. 2021 Jul 11;13(7):2374. 

    Samsami-Kor M, Daryani NE, Asl PR, Hekmatdoost A. Arch Med Res. 2015 May;46(4):280-5. 

    Yoshino M, Yoshino J, Kayser BD, Patti GJ, Franczyk MP, Mills KF, Sindelar M, Pietka T, Patterson BW, Imai SI, Klein S. Science. 2021 Jun 11;372(6547):1224-1229. 

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