Longevity Articles

NMN Supplements Comparison: How Does NMN Powder Compare To Capsules and Sublingual Supplements?

How Does NMN Powder Compare To Capsules and Sublingual Supplements?
ProHealth's pure NMN supplements are very expensive to make. That's why we've created a wide selection of NMN powder. Our NMN Pro Powder is available in a 15-gram container, in 2, 3, and 6-packs of 15-gram bundles, and in bulk packaging containing 250, 500 and 1,000 (one kilo!) grams of pure NMN.

Because our manufacturing costs for producing NMN powder are less than they are for NMN capsules or sublingual supplements we offer, we pass those savings on to you.

That said, we understand that some people prefer the simplicity of swallowing an NMN capsule or tablet, or placing an NMN lozenge under their tongue for sublingual delivery. Thus, I'd like to quickly review these different NMN product types, so you can get a better idea about which you might prefer.

But first, a few words about the potential value of supplementing with NMN.

NMN Is Valuable Because It Boosts NAD+ Production

NMN is short for nicotinamide mononucleotide, which is a derivative of the B-vitamin niacin. NMN is a molecule that plays a crucial role in energy production, metabolism, and gene expression in the body. It does this by boosting NAD+, a coenzyme found in nearly all our cells that is essential for life.

When NMN levels in the body are increased, the biosynthesis of NAD+ is enhanced, thereby alleviating the symptoms associated with depletion of this crucial nutrient. And over time, it NAD+ surely does get depleted on our body. Take a look at this graph:
NMN powder, capsules, tablets and lozenges may help boost NAD+

NAD+ levels tend to drop by as much as 50% as we get older. [1]

The 50% decline happens by age 50 for a typical person, but NAD+ just keeps on marching downward as we age, eventually getting to between 1 and 10% by the time we reach 80 years of age. [2]

Yes, it's bad news is that NAD+ naturally declines as we age. But there's good news -- NMN supplementation can boost NAD+ levels, and by doing that can potentially lead to at least six favorable health outcomes:

  1. NMN may support vascular health and muscle growth
  2. NMN may support healthy body composition by lowering body fat
  3. NMN may support healthy energy levels
  4. NMN may support healthy blood sugar regulation
  5. NMN may support healthy heart function
  6. NMN may support cognition with age
(For more on this, read The 8 Most Important Things You Need to Know About NMN.)

Mind you, although NMN is currently being studied in humans (which has shown that it's safe), all the beneficial health outcomes attributed to NMN comes from animal studies so far. Research has shown that the cellular age of mice could decrease from two years to six months after being given molecules of NAD+ and NMN powder mixed in water. He concluded that higher NAD+ levels make cells behave younger and more vibrant

That's great for mice, and, yes, I know it's unlikely that you're a mouse.

And yet, if all we had to go on regarding the potential effectiveness of NMN powder to increase NAD+ were mouse studies, I'd still be encouraged. Mice are used as models in medical testing because their genetic, biological, and behavior characteristics closely resemble those of humans. [3]

If you're intrigued by the potential of NMN supplementation, one relevant question is which type to take: the NMN powder, capsule, tablet, or sublingual lozenge?

Best Way to Take NMN Powder: ProHealth Has Four Options

Figuring out how to take NMN powder is simple when ProHealth offers so many different ways. Here are four ways to take NMN powder:

1. NMN Powders

NMN Pro powder is ideal for those looking for a high daily dose of NMN in its purest form. It's available in one, three, and six packs of 15 gram containers of NMN powder. NMN Bulk Powder is packaged in 250, 500 and 1,000-gram mylar bags.

ProHealth's NMN powder allows NMN to be absorbed directly into the blood vessels in the mouth and under the tongue, which increases the product's bioavailability. In this way, NMN avoids digestion in the gastrointestinal tract and can be more rapidly delivered into the bloodstream.

Our NMN Pro Powder also allows for greater flexibility in how you administer you daily NMN dose.  For instance, our NMN powder is highly water soluble, which enables you to dissolve the powder into water and sip it over a short period of time.  

2. NMN Tablets

ProHealth has two different doses of NMN tablets in acid-resistant configurations:
  • NMN Pro 150 in a single bottle of 60, 150-mg acid-resistant tablets.
  • NMN Pro 250 Extended Release in a single bottle a six-pack of 30, 250-mg tablets per bottle.

All of ProHealth's tablets are designed to slow and prolong NMN absorption, allowing a longer steady blood level concentration of the active ingredient. In animal studies, NAD+ blood levels were elevated for six hours, as compared to approximately six minutes in non-stabilized NMN studies.

ProHealth has recently reformulated NMN Pro 250 to make it the most advanced NMN delivery method available. To protect the delicate NMN molecule from stomach acid and extend the release of NMN, we combined our pure NMN with a patented pea protein. This novel formulation allows for the NMN to be released into the intestines over a several hour period.

Releasing the NMN in the small intestine allows for pure NMN to come in contact with the Scl12A8 NMN-transporter protein for an extended period of time. This delivery system keeps the NMN from degrading in gastric acid and allow the NMN to be delivered to the area in the body that enables the greatest level of uptake into the cells. The slow dissolve of NMN Pro 250 has the ability to prolong NAD+ blood concentration levels, allowing for less frequent doses while maintaining increased NAD+ levels

3. NMN Capsules

Our NMN Pro 300 Enhanced Absorption is available in bottles of 60, 150-mg capsules (two per serving) in one, two, three and six-pack configurations.

NMN Pro capsules offer you a familiar and convenient method of administering NMN. ProHealth uses a patented delayed-release capsule to bypass the harsh stomach environment and deliver NMN directly to the small intestine for greater bioavailability. Unlike NMN Pro 250 tablet, NNM Pro 150 and 300 capsules deliver the entire dose of NMN upon entering the small intestine, providing the user an immediate spike in NAD+ blood concentration.

NMN Pro 150 and Pro 300 feature organic rice flour as the only other ingredient in the formula. Organic rice flour allows for the product to be encapsulated without using chemical excipients that may impact the bioavailability of the NMN or cause stomach upset.

4. NMN Lozenges

NMN Pro Lozenges are offered in a single bottle of 30, 250-mg lozenges, and two and six packs.

ProHealth's NMN lozenges are taken sublingually and significantly enhance NMN bioavailability, meaning that your body can absorb the NMN into the blood vessels underneath the tongue, and in the buccal mucosa.

NMN lozenges dissolve over 4 to 5 minutes in the mouth, avoiding digestion in the gastrointestinal tract. Moreover, the NMN lozenges feature erythritol, a sugar alcohol that acts as a catalyst to improve the absorption of NMN into the bloodstream.  

NMN Pro lozenges offer a lightly sweet lemon flavor and a come in a unique desiccant-lined bottle that helps ensure full potency of the product after it is opened

NMN Sublingual vs Oral

Why take sublingual NMN over oral consumption? There are some pros and cons to each. First, the sublingual method is absorbed faster because it’s entering directly into the bloodstream. Plus, since it’s not going through your digestive system, you’re getting more of the benefits because you’re not losing any in the process of digestion.

One advantage of the oral method is the delayed release that can reduce the quantity you need to consume to maintain the positive effects.

ProHealth's NMN Is Safe, Pure, and Does Not Degrade

There's been some speculation about whether NMN is safe and if its purity degrades over time if not refrigerated.

As I wrote in Study Shows NMN Is Safe For Humans:

"The study was done on only ten healthy men, ages 40 to 60. They were given a single oral administration of 100, 250, and 500 mgs of NMN. The men were then evaluated to see how those dosages of NMN affected various health parameters."

"The researchers found that no single oral administration of NMN caused any significant clinical symptoms or changes in heart rate, blood pressure, oxygen saturation, or body temperature."

I also addressed the stability issue in NMN Supplement Shelf Life - What You Need To Know, where I underscored that ProHealth's NMN supplement products remain nearly 100% pure up to three months in temperatures between 39.2° F (4°C) and 104°F (40°C), as the lab tested and produced NMN Stability Report details below.

What's not included in this particular document is that subsequent tests showed over 98% NMN supplement purity at the six month mark as well. Unless you do not intend to use our NMN supplement within six months of delivery, you don't need to refrigerate it.

Frequently Asked Questions About NMN Powder

What is NMN Powder

NMN is a naturally occurring molecule that exists in all living organisms. It has a few main purposes. Some of these include repairing damaged DNA, which has an anti-aging effect that not only impacts the way you look but it also has an effect on the way you feel. Nicotinamide mononucleotide (NMN) comes from the B-vitamin, niacin, which plays an important role in metabolism, gene expression, and energy production.

What is NMN good for?

Some of the reasons people take NMN powder include: anti-aging by restoring NAD+ levels, cardiac health, weight management, endurance, muscle support, and energy support. All of these factors are especially important as we age. Our metabolism slows down, our energy levels drop, and we begin to feel our age taking over. NMN is an option that can help you get back to the youthful feeling you’re used to.

How should one take NMN powder?

The best way to take NMN powder is sublingually. You’ll take one scoop and put it under your tongue 1-4 times per day. You can also dissolve the powder in water and take it that way. Taking NMN sublingually allows you to consume a high dose without having to take a bunch of tablets.


ProHealth’s NMN supplements are stable without refrigeration for at least six months

Your Takeaway

All of ProHealth's NMN supplements are pure NMN, safe to take, and shelf-stable. They're also designed for enhanced absorption, so you can be confident of its potential to boost NAD+ and thereby confer many desired health benefits offered by high NAD+ levels.

The decision about which NMN formulation to try should be guided by which you're most likely to take on a consistent basis, and the price per serving most appealing to you given the upfront cost. NMN powders are generally less expensive to make than capsules and tablets and thus less costly for you, and the multiple bottle offerings also reduce the per price serving.


Visit our shop to choose the right NMN Supplement for you
  1. https://www.lifeextension.com/Magazine/2018/2/Anti-Aging-Effects-Of-NAD
  2. https://www.abc10.com/article/news/health/why-do-we-experiment-on-rats-and-mice-for-human-research/373516158

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