Longevity Articles

Using the Secrets in Our Cells: How NMN Pro Complete Enhances Longevity

Using the Secrets in Our Cells: How NMN Pro Complete Enhances Longevity

Aging is inevitable, but some scientists argue that the toll that time takes on our bodies can be delayed. For how long? We donā€™t know yet, but we do know some ways to extend our healthy years and delay the various physiological changes that can impact our overall health as we grow older.

One major factor in maintaining healthy aging is the molecule nicotinamide adenine dinucleotide (NAD+), which plays a significant role in cellular processes.

Understanding NAD+ and Its Significance in Aging

NAD+ is a vital molecule found in every living cell, responsible for cellular survival, functionality, and energy metabolism. As we age, NAD+ levels tend to decline, affecting the efficiency of NAD+-dependent enzyme functions. This decline leads to cellular damage, oxidative stress, and ultimately, cellular dysfunction.

Sirtuin enzymes, also known as "longevity genes," rely on NAD+ for proper functioning and are responsible for numerous essential cellular processes. Sirtuin activation is associated with a healthy metabolism, DNA integrity, and influences immune system, cardiac, and neural functions, ultimately impacting overall health and aging.

By enhancing NAD+ levels and improving cellular utilization, we can potentially support healthy aging, and this is precisely where NMN supplements come into play.

Sirtuin activation is associated with a healthy metabolism, DNA integrity

What is NMN?

Nicotinamide mononucleotide (NMN) is a precursor to NAD+, meaning that it can be directly converted into NAD+. Research has demonstrated that NMN can help restore and elevate NAD+ levels, ultimately improving the metabolism of this critical molecule. By doing so, NMN supplements can support the healthy aging process.

NMN Pro Complete For Optimal NAD+ Support

ProHealth NMN Pro Complete blends three synergistic ingredients so you can experience the most benefits and maximize effectiveness. These three powerful molecules work together to provide the cofactors necessary for cellular energy production and repair.

  • Nicotinamide mononucleotide (NMN): As discussed above, NMN is a precursor to NAD+ and aids in restoring and elevating NAD+ to more youthful levels.
  • Resveratrol: This plant-based compound acts as a sirtuin activator and is found in sources such as red grapes, peanuts, and berries. Resveratrol demonstrates antioxidant properties and contributes to numerous health benefits, including activation of the sirtuin DNA repair enzymes. We use only the trans- form of resveratrol, since itā€™s this form that is responsible for the benefits seen from this supplement.
  • Trimethylglycine (TMG): TMG is a methyl donor that works synergistically with NMN supplements. It helps replenish the body's methyl pool, a reserve of co-factors involved in many metabolic functions that affect heart, brain, reproductive system, liver, and DNA health.

NMN Benefits and Its Role in Healthy Aging

Studies in animal models have shown numerous health benefits of NMN, including the maintenance of healthy mitochondria, which are essential for the proper functioning and aging of various organ systems such as the circulatory, nervous, and cardiovascular systems. Recent research on NMN has indicated that the NAD+ precursor decreases cell senescence, an aging process wherein cells become dormant and cease growth and division.

Senescent cells are doubly problematic. First, they can only perform some of their normal metabolic functions and are unable to divide. Second, they release cytokines, molecules that signal to neighboring cells that the tissue is damaged, amplifying the negative impact of inflammaging.

In human studies, NMN has been shown to increase NAD+ levels, with some of the best responses observed in specific NMN formulations, including UtheverĀ® NMN, the form used in NMN Pro Complete. Moreover, clinical research has found that NMN supplementation appears to enhance NAD+ metabolism and offer health benefits, such as significantly reduced blood lipid levels.

Exploring the Benefits of Resveratrol

Resveratrol is primarily known for its antioxidant properties; however, clinical research has also shown that it supports healthy blood sugar metabolism, gut immune responses, and cerebral blood flow. Recent studies have demonstrated that resveratrol supplementation reduces inflammatory pathways ā€“ a process increasingly associated with aging.

Furthermore, resveratrol may influence cognitive brain aging processes, delay their effects, and decrease their occurrence. A comprehensive review has summarized that resveratrol exerts numerous favorable effects on the heart, blood vessels, longevity regulation, energy metabolism, stress resistance, circadian rhythms, and microbiota composition.

The Role of TMG in Healthy Aging

TMG supports the body's metabolism of the amino acid homocysteine, which is linked to cardiovascular issues when present at elevated levels. Studies on rodents have shown that TMG may help decrease harmful fatty liver deposits, while in human cells, it appears to counteract bone and muscle aging.

Recent clinical trials have demonstrated that increased dietary TMG intake is associated with improvements in cardiometabolic parameters and protection against age-related loss of skeletal muscle mass.

TMG intake is associated with improvements in cardiometabolic parameters and protection against age-related loss of skeletal muscle mass.

How Much NMN Should I Take?Ā 

When taking an NMN supplement, follow the recommended dosage on the ProHealth label, as our formulations are based on the most recent data for safety and effectiveness. Generally, top longevity specialists recommend a daily dose that includes 1,000 mg of NMN, 1,000 mg of trans-resveratrol, and 500 mg of TMG, which are found together in a single dose of NMN Pro Complete.

Where to Buy NMN Supplements

To ensure the highest quality and efficacy, purchase NMN supplements only from reputable sources. Look for products that undergo third-party laboratory inspection by professional analytical laboratory services, adhere to current Good Manufacturing Practice (GMP) regulations, and follow NSF, FDA, and ISO guidelines and standards. Certificates of Analysis are available for ProHealth NMN Pro Complete, ensuring transparency and quality.

How to Incorporate NMN Supplements into Your Daily Routine

NMN supplements can be easily incorporated into your daily routine. It is essential to follow the recommended dosage provided by the manufacturer and consult with a healthcare professional before starting any supplementation, especially if you have existing health conditions or are taking medications.

Safety Considerations and Potential Side Effects

Generally, NMN supplements are considered safe for most individuals when taken as directed. However, it is essential to consult with a healthcare professional before starting any supplementation, especially if you have existing health conditions or are taking medications. Some users may experience mild side effects such as gastrointestinal discomfort or skin rash, though these are generally rare and resolve on their own.

Embracing the Potential of NMN Supplements for Healthy Aging

NMN supplements have shown promising results in supporting healthy aging by enhancing NAD+ levels and improving cellular utilization. The unique combination of NMN, TMG, and trans-resveratrol offers a potent, high-quality, and pure solution for individuals seeking to stave off the effects of aging.

By incorporating an NMN supplement like ProHealth NMN Pro Complete into your daily routine and following the recommended dosage, you can potentially support your overall health and well-being as you age. Remember to consult with a healthcare professional before starting any supplementation and choose a reputable source for your NMN supplement to ensure quality and efficacy.Ā 

References:

Garrigue P, Mounien L, Champion S, Mouhajir Y, Pechere L, Guillet B, Landrier JF, Seree E. Long-term administration of resveratrol at low doses improves neurocognitive performance as well as cerebral blood flow and modulates the inflammatory pathways in the brain.Ā J Nutr Biochem.Ā 2021 Nov;97:108786. doi: 10.1016/j.jnutbio.2021.108786. Epub 2021 Jun 1. PMID: 34082127.

Huang, H. (2022). A Multicentre, Randomised, Double Blind, Parallel Design, Placebo Controlled Study to Evaluate the Efficacy and Safety of Uthever (NMN Supplement), an Orally Administered Supplementation in Middle Aged and Older Adults. Frontiers in Aging, 3, 851698. https://doi.org/10.3389/fragi.2022.851698

Irie J, Inagaki E, Fujita M, Nakaya H, Mitsuishi M, Yamaguchi S, Yamashita K, Shigaki S, Ono T, Yukioka H, Okano H, Nabeshima YI, Imai SI, Yasui M, Tsubota K, Itoh H. Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men.Ā Endocr J.Ā 2020 Feb 28;67(2):153-160. doi: 10.1507/endocrj.EJ19-0313. Epub 2019 Nov 2. PMID: 31685720.

Rabbani N, Xue M, Weickert MO, Thornalley PJ.Ā Nutrients. 2021 Jul 11;13(7):2374. doi: 10.3390/nu13072374. PMID: 34371884; PMCID: PMC8308792.

Samsami-Kor M, Daryani NE, Asl PR, Hekmatdoost A.Ā Arch Med Res. 2015 May;46(4):280-5. doi: 10.1016/j.arcmed.2015.05.005. Epub 2015 May 20. PMID: 26002728.

Yi, L., Maier, A.B., Tao, R.Ā et al.Ā The efficacy and safety of Ī²-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial.Ā GeroScienceĀ 45, 29ā€“43 (2023). https://doi.org/10.1007/s11357-022-00705-1

Yoshino M, Yoshino J, Kayser BD, Patti GJ, Franczyk MP, Mills KF, Sindelar M, Pietka T, Patterson BW, Imai SI, Klein S. Nicotinamide mononucleotide increases muscle sensitivity in prediabetic women.Ā Science. 2021 Jun 11;372(6547):1224-1229. doi: 10.1126/science.abe9985. Epub 2021 Apr 22. PMID: 33888596; PMCID: PMC8550608.

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