What's the Best NAD+ Supplement?
So the "best NAD+ supplement" question is really a question about which precursor (NMN or NR) is best supported by evidence and documentation. Here's how we'd break that down.
NMN vs. NR: the two main options
Both NMN (nicotinamide mononucleotide) and NR (nicotinamide riboside) are precursors your body converts into NAD+. NMN has a published, peer-reviewed, double-blind, placebo-controlled human RCT (Uthever® NMN, up to a 38% increase in blood NAD+ levels). NR has its own separate body of human research, including a 2018 study from the Imai lab (Martens et al., Nature Communications) showing it's well-tolerated and raises NAD+ in healthy middle-aged and older adults. A 2026 head-to-head comparison found NR raised blood NAD+ more than NMN under their specific test conditions, so we wouldn't call this a settled question either way.
What about NADH or direct NAD+ products?
both molecules are large and don't cross cell membranes efficiently when taken orally, which is a big part of why precursor supplementation (NMN/NR) became the more research-backed approach
So what should you actually look for?
The same documentation criteria that matter for any NAD+ precursor product: a certificate of analysis, independent third-party testing, GMP/FDA facility registration, and a clearly disclosed ingredient source with its own safety and purity documentation. I
Where we fit
Our NMN Pro™ products use Uthever® NMN, backed by the published human RCT referenced above, manufactured in an FDA-registered, cGMP-certified US facility, and independently verified against its label claim in ChromaDex's 2021 testing of NMN products on the market. You don't have to take our word for any of that - they’re all things you can go check yourself.
References:
Uthever® NMN clinical study. Frontiers in Aging, 2022. DOI: 10.3389/fragi.2022.851698
Martens CR, et al. "Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults." Nature Communications, 2018. DOI: 10.1038/s41467-018-03421-7
Yoshino M, et al. "Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women." Science, 2021. DOI: 10.1126/science.abe9985