NAD Triple Boost™ - 90 capsules

The Ultimate All-in-One NAD+ Support Formula*

• Rapidly increases NAD+ levels*^{1-3,5–8,13,16}
• Enhances cellular energy production*^2,3,5,16,17
• Promotes DNA repair & stability*^1-3
• Supports brain & heart health*^1-3,8
• Helps counter the effects of aging*^{2,3,5,11,13,16,17}

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NAD+ Optimization—Done Right

NAD+ is more than a molecule—it’s a foundational driver of healthy aging, powering energy production, cellular repair, and resilience. But truly effective NAD+ support goes beyond simply adding precursors. It requires a comprehensive strategy that:

• Rebuilds NAD⁺ from multiple molecular entry points*
• Protects NAD⁺ from depletion and degradation*
• Enhances how cells convert NAD⁺ into usable energy*

ProHealth’s NAD⁺ Triple Boost is built on this systems-level approach. It goes beyond surface-level support—targeting every key stage of the NAD+ lifecycle, from replenishment and protection to cellular utilization. Backed by science and designed for real results, it helps restore what aging depletes—delivering noticeable, whole-body vitality you can truly feel.*^1-3,6-8

Pioneering Longevity Since 1988

For over 36 years, ProHealth has been dedicated to crafting the world’s highest-quality supplements—rooted in innovation, integrity, and a passion for healthy aging. With a long-standing A+ rating from the Better Business Bureau, our reputation for purity and potency has made us one of the most trusted names in the industry. Our commitment to scientific rigor, premium sourcing, and results you can feel continues to drive everything we do.

What Sets Us Apart

• Doctor-Formulated: Developed by our in-house science team in collaboration with leading wellness experts to address the root causes of aging.*
• Triple Lab Tested: Rigorously tested three times by independent third-party labs to guarantee unmatched potency and purity.
•  Full Transparency: In an industry full of misleading claims, we publish our third-party lab results—so you always know exactly what’s in every bottle.
• Manufactured in the USA: Since 1988, we’ve proudly produced our supplements in FDA-regulated, GMP-certified facilities, ensuring the highest quality and safety standards.
• 100-Day Risk-Free Guarantee: We stand behind our products. If you’re not completely satisfied, contact our Santa Barbara, CA office for a full refund—no hassle, no questions asked.

All-In-One: Replenishment, Protection & Utilization

NAD+ is essential for life—powering over half of the body’s biochemical reactions and playing a critical role in energy production, metabolism, and cellular resilience. But as we age, NAD+ levels naturally decline, leaving our cells less capable of performing, repairing, and thriving. Replenishing and sustaining NAD+ is key to reviving cellular energy and supporting long-term vitality.*^1-3,16

Multi-Pathway NAD+ Replenishment

The body produces NAD+ through multiple biochemical pathways. By supplying a diverse range of precursors, this formula activates several key routes of NAD+ synthesis to help sustain healthy, youthful levels of this essential coenzyme.*^1,2,5,8

• Nicotinamide Riboside (NR): A clinically studied vitamin B3 derivative that fuels the Salvage Pathway, helping to recycle NAD+ and effectively boost NAD+ levels to support mitochondrial function, sirtuin activity, and cellular resilience.*^2,16,17
• Vitamin B3: Includes two forms—niacin and niacinamide—that fuel distinct NAD+ pathways. Niacin activates the Preiss–Handler Pathway, while niacinamide supports the Salvage Pathway, the body’s primary route for recycling NAD+.*^7,13
• Tryptophan: This essential amino acid not only aids serotonin synthesis but also fuels the De Novo Pathway, enabling the body to generate NAD+ from scratch through a multistep enzymatic process.*^1,2,7
• Reduced NMN (NMNH): A cutting-edge NAD+ precursor that supports a Novel Pathway. As the reduced form of NMN, NMNH bypasses rate-limiting steps in the Salvage Pathway for faster, more efficient NAD+ generation.*⁸

Protect Your NAD+ Supply*

Even as the body produces NAD+, it can be rapidly depleted by enzymes like CD38. This formula includes targeted compounds to help minimize NAD+ loss and extend its availability for cellular function.*

• Apigenin: A plant flavonoid found in parsley, celery, and chamomile, apigenin targets CD38—a NAD+ consuming enzyme—thereby helping to preserve your body's NAD+ stores.*⁴

Enhance NAD+ Utilization*

Optimal NAD+ levels are only part of the equation. Your cells must efficiently use NAD+ to power critical enzymes and pathways related to aging and cellular health.*

• B Vitamins: (including methyl-folate and methyl-B12): Support ATP production and methylation pathways, which are essential for both energy metabolism and the recycling of NAD+ breakdown products.*^9-12
• Stilbenoids (Resveratrol, Pterostilbene, & Piceatannol): Powerful polyphenol compounds known to enhance the activity of sirtuins—a family of enzymes that use NAD+ to regulate DNA repair, metabolic function, and healthy aging. By activating sirtuins, they help amplify the benefits of increased NAD+ levels.*^14,15

A Word from our Chief Science Officer

“The NAD+ ecosystem isn’t a single switch—it’s a dynamic, ever-evolving network of pathways, feedback loops, and cellular compartments that change with age. That’s why NAD⁺ Triple Boost was built to go beyond simple replenishment. By targeting multiple control points across the entire NAD+ system, we’re helping the body unlock its full regenerative potential. This is truly a smarter, more complete approach to NAD⁺ optimization.”

The Global Leader in NAD+ Support

ProHealth offers the world’s most comprehensive collection of NAD+ boosting supplements. From foundational ingredients like NR and NMN to next-generation compounds such as NMNH and Apigenin, our lineup spans every major pathway involved in NAD+ production and preservation. With multiple delivery forms, clinically-studied ingredients, and advanced formulations designed to target energy, metabolism, brain health, and longevity, ProHealth is the global leader in NAD+ support—trusted by health seekers, researchers, and practitioners alike.*

• Nicotinamide Riboside (NR): A clinically studied form of vitamin B3 that supports the NAD+ salvage pathway, helping replenish cellular NAD+ levels efficiently.*
• Tryptophan: An essential amino acid that feeds the De Novo NAD+ pathway.*
• Apigenin: A plant-based flavonoid that helps preserve NAD+ levels by targeting CD38, an enzyme known to degrade NAD+ in the body.*
• Targeted B Vitamins: Includes methylated and bioactive B vitamins that support mitochondrial energy production and provide methyl groups crucial for NAD+ metabolism.*
• Magnesium: A vital cofactor required for enzymatic reactions in NAD+ synthesis and ATP production, supporting optimal cellular energy function.*
• Resveratrol: A polyphenol that activates sirtuins—NAD+ dependent enzymes linked to longevity, cellular repair, and healthy aging.*
• Pterostilbene: A powerful polyphenol related to resveratrol, known for its superior bioavailability and ability to activate sirtuins, support antioxidant defenses, and promote healthy NAD+ metabolism.*
• NMNH (Reduced NMN): A next-generation NAD+ precursor that bypasses key rate-limiting steps to support faster, more efficient NAD+ production through an alternative biochemical pathway.*
• Piceatannol: A naturally occurring stilbenoid that supports healthy inflammation signaling and may complement sirtuin activation and cellular resilience mechanisms.*

References:

1. Conlon N et al. Biochem Pharmacol. 2022;198:114946.
2. Rajman L et al. Cell Metab. 2018;27(3):529-547.
3. Xie N et al. Signal Transduct Target Ther. 2020;5(1):227.
4. Kramer DJ et al. Front Nutr. 2024;11:1359176.
5. Membrez M et al. Nat Metab. 2024;6(3):433-447.
6. Yang Y et al. J Biol Chem. 2019;294(23):9295-9307.
7. Palmer RD et al. Aging Med (Milton). 2021;4(3):214-220.
8. Zapata‐Pérez R et al. FASEB J. 2021;35(4).
9. Oregon State University - Linus Pauling Institute. Magnesium. Accessed July 26, 2024. https://lpi.oregonstate.edu/mic/minerals/magnesium.
10. National Institutes of Health. Magnesium Fact Sheet for Health Professionals. Accessed July 26, 2024. https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional.
11. Dominguez LJ et al. Nutrients. 2024;16(4):496.
12. Barbagallo M et al. Magnes Res. 2009;22(4):235-246.
13. Freeberg KA et al. J Gerontol A Biol Sci Med Sci. 2023;78(12):2435-2448.
14. Briskey D and Rao A. Pharmaceutics. 2020;12(12):1190.
15. Wei Y et al. Int J Biol Macromol. 2024;270:132026.
16. Orr ME et al. GeroScience. 2024;46(1):665-682.
17. Dolopikou CF et al. Eur J Nutr. 2020;59(2):505-515. .