Acetyl-L-Carnitine - 500 mg, 120 capsules

SKU: PH640

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Research-Supported Benefits:

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Enhancement of Cognitive Function: Acetylcarnitine has been shown to support cognitive health, particularly in age-associated memory impairment (1, 2). Research has found that older adults who supplemented with acetyl L-carnitine had improvements in mental fatigue, functional status, and memory scores, indicating enhanced cognitive function (2). These benefits may arise because acetylcarnitine can cross the blood-brain barrier and modulate synaptic transmission and the activity of neurotransmitters, hormones, and neurotrophic factors. (3)

Neuroprotective Effects: Studies indicate that acetylcarnitine possesses neuroprotective properties which can be beneficial in reducing the effects of aging on the brain. Acetylcarnitine enhances the production of acetylcholine—a neurotransmitter needed for central nervous system and peripheral nervous system functioning. Acetylcholine plays a vital role in memory, cognition, attention, and neuroplasticity (1).

Mitochondrial Function and Energy Metabolism: Acetylcarnitine may enhance mitochondrial function, which is crucial for healthy aging, as mitochondrial dysfunction is a hallmark of the aging process. Research shows that acetyl L-carnitine improves mitochondrial cellular metabolism in aged rats, which also led to improved biomarkers of cellular aging (4).

Antioxidant Properties: Acetylcarnitine exhibits antioxidant activities, helping to combat oxidative stress, a significant factor in accelerated aging. In aged rats, acetylcarnitine is shown to be effective in reducing markers of oxidative stress and lipid peroxidation, two common cellular markers of aging (4).

Cardiovascular Health: Research shows that acetylcarnitine may benefit cardiovascular health by improving blood flow and reducing the risk of heart-related conditions (5).

Muscle Mass Preservation: Acetylcarnitine may aid in preserving muscle mass, which tends to decline with age. This may be due to its effects on mitochondrial function and energy metabolism. In older adults with muscle fatigue, taking acetylcarnitine increased total muscle mass and reduced physical fatigue by 40% (6).


1. Traina G. The neurobiology of acetyl-L-carnitine. Front Biosci (Landmark Ed). 2016;21(7):1314-1329. Published 2016 Jun 1. doi:10.2741/4459

2. Malaguarnera M, Gargante MP, Cristaldi E, et al. Acetyl L-carnitine (ALC) treatment in elderly patients with fatigue. Arch Gerontol Geriatr. 2008;46(2):181-190. doi:10.1016/j.archger.2007.03.012

3. Chen N, Yang M, Zhou M, Xiao J, Guo J, He L. L-carnitine for cognitive enhancement in people without cognitive impairment. Cochrane Database Syst Rev. 2017;3(3):CD009374. Published 2017 Mar 26. doi:10.1002/14651858.CD009374.pub3

4. Hagen TM, Liu J, Lykkesfeldt J, et al. Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress [published correction appears in Proc Natl Acad Sci U S A 2002 May 14;99(10):7184]. Proc Natl Acad Sci U S A. 2002;99(4):1870-1875. doi:10.1073/pnas.261708898

5. DiNicolantonio JJ, Lavie CJ, Fares H, Menezes AR, O'Keefe JH. L-carnitine in the secondary prevention of cardiovascular: systematic review and meta-analysis. Mayo Clin Proc. 2013;88(6):544-551. doi:10.1016/j.mayocp.2013.02.007

6. Pistone G, Marino A, Leotta C, Dell'Arte S, Finocchiaro G, Malaguarnera M. Levocarnitine administration in elderly subjects with rapid muscle fatigue: effect on body composition, lipid profile and fatigue. Drugs Aging. 2003;20(10):761-767. doi:10.2165/00002512-200320100-00004

Acetylcarnitine is a potent compound for supporting cognitive, neurological, and mitochondrial health. Playing an essential role in our critical metabolic processes, acetylcarnitine shows great promise for enhancing longevity and supporting healthy aging from the inside out.

Also known as acetyl L-carnitine or ALCAR, this compound assists in mitochondrial fatty acid metabolism and enhances the production of the neurotransmitter acetylcholine—a vital brain chemical for cognitive functioning.

Although it’s related to the amino acid L-carnitine, acetylcarnitine is better absorbed and can cross the highly selective blood-brain barrier more rapidly, allowing for increased effectiveness in targeting cognitive or neurological concerns (1).

Research shows that acetylcarnitine has antioxidant properties that protect our cells and mitochondria. It also supports nerve function, energy metabolism, heart health, and muscle mass.

Supplement Facts
Serving Size: 1 Capsule
Servings Per Container: 120
Amount Per Serving %DV
500 mg
† Daily Value not established

REV. 11.23

  • OTHER INGREDIENTS: Vegetable capsule, microcrystalline cellulose, rice our.
  • DOES NOT CONTAIN: Dairy, egg, soy, wheat, gluten, fish, shellfish, tree nuts, peanuts.
  • SUGGESTED DAILY USE: Take 1-3 capsules per day, or as directed by your healthcare
  • NOTE: Store in a cool, dry place, away from direct sunlight. Do not use if tamper evident seal is broken or missing. KEEP OUT OF REACH OF CHILDREN.
  • CAUTION: Not intended for use if you are pregnant or nursing. Not formulated for use in children. If you have a medical condition or are taking medications, consult with your healthcare professional before using this product.
  • Quality Manufacturing Practices. All of our products are manufactured in an FDA-registered, GMP-certified facility.
  • Third-Party Tested in the USA. Every batch is third-party tested in US laboratories to ensure the highest quality, purity and potency. Certificates of Analysis are available.

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Customer Reviews

Based on 2 reviews
Increased energy levels & mental clarity

I have been taking Acetyl-L-Carnitine for a few weeks now and have noticed a significant increase in my energy levels and mental clarity. I appreciate that it is made with high-quality ingredients and is easy to take. Overall, I highly recommend this product to anyone looking for a natural way to boost their energy and mental performance.

Joe C.
Great addition

Awesome addition to my longevity stack!

Frequently asked questions

It's recommended to take acetyl L-carnitine on an empty stomach in the morning due to its energy-promoting effects.
They are similar and both support mitochondrial function, but acetyl L-carnitine is thought to be better absorbed than L-carnitine.