Berberine Plus Cinnamon - 1800 mg per day, 90 capsules

SKU: PH647

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Berberine is a bioactive plant extract with thousands of years of historical use in Ayurvedic and Chinese medicine. It is referred to as a ‘pleiotropic,’ meaning that it influences the activity of many body systems. Berberine is best known for its support in blood sugar balance, but it also supports many biochemical pathways related to longevity and healthy aging. This formula contains BioPerine® to help boost bioavailability. Cinnamon has been included due to its historical use for the support of healthy metabolic function.*


  • Supports glucose metabolism*
  • Supports healthy aging and longevity*
  • Supports lipid metabolism and cardiovascular health*
  • Helps maintain a healthy gut microbiome*

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Helps maintain healthy blood sugar levels. Many clinical studies have explored the potential supportive role of berberine in blood glucose homeostasis. Evidence suggests that berberine plays many biochemical roles to support healthy blood sugar: inhibit gluconeogenesis, stimulate glycolysis, help reduce intestinal glucose absorption, and help increase glucose uptake in the liver and muscles.*

Supports healthy aging and longevity. Berberine supports many cellular functions associated with the hallmarks of healthy aging. It helps support mitochondrial integrity through the inhibition of oxidative damage and helps activate AMPK phosphorylation, which in turn helps support cellular energy production. Berberine may also help to support the proliferation of healthy cells.*

Helps maintain cholesterol levels within normal range. A clinical study involving 1000 mg of berberine daily for 12 weeks reported improvements in total cholesterol and HDL-C levels.1 Berberine may also help support healthy adipogenesis and pathways related to antioxidative status.*

Helps nourish a healthy gut microbiome. Berberine interacts extensively with gut microbiota. Research shows that berberine exhibits a prebiotic-like effect, promoting the growth of Akkermansia (a keystone probiotic) by stimulating gut mucin secretion.*

Stacks well with: CoQ10Alpha Lipoic AcidKrill Oil


  1. Zhao JV et al. Nutrients. 2021;13(8):2550.
  2. Gasmi A et al. Curr Med Chem. 2024;31(10):1214-1234.
  3. Neag MA et al. Front Pharmacol. 2018;9:557.
  4. Imenshahidi M, Hosseinzadeh H. Phytother Res. 2019;33(3):504-523.
  5. Li M, Zhang H, Zhang Y, et al. J Immunol. 2022;208(10):2309-2318.
  6. Dong C et al. Biomedicine & Pharmacotherapy. 2021;139(7):111595.
  • Activates the AMPK (adenosine monophosphate-activated protein kinase) pathway. AMPK is associated with glucose metabolism.*
  • Supports biochemical pathways related to glycolysis and cellular energy.*
  • Healthy aging support through cell-cleanup and mitochondrial maintenance.*
Supplement Facts
Serving Size: 1 Capsule
Servings Per Container: 90
Amount Per Serving %DV
Berberine HCl
600 mg
Ceylon Cinnamon (Cinnamomum verum) Powder 100 mg
Alpha Lipoic Acid 33 mg
BioPerine® Black Pepper Fruit Extract (95% Piperine)
3.3 mg
† Daily Value not established


  • OTHER INGREDIENTS: Vegetable capsule.
  • DOES NOT CONTAIN: Dairy, egg, soy, wheat, gluten, fish, shellfish, tree nuts, peanuts.
  • SUGGESTED DAILY USE: Take one capsule three times a day with food, or as directed by your healthcare professional.
  • NOTE: Store in a cool, dry place, away from direct sunlight. Do not use if tamper-evident packaging is broken. KEEP OUT OF REACH OF CHILDREN.
  • CAUTION: Not intended for use if you are pregnant or nursing. Not formulated for use in children. If you have a medical condition or are taking medications, consult with your healthcare professional before using berberine, due to the risk of interactions and low blood sugar levels.
  • Science-first formulations. We source only the highest quality ingredients backed by validated research to help you achieve your longevity goals.
  • Quality Manufacturing Practices. All of our products are manufactured in a FDA-registered, GMP-certified facility.
  • Third-Party Tested in the USA. Every batch is third-party tested in US laboratories to ensure the highest quality, purity and potency. Certificates of Analysis are available.

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