Fisetin Pro Longevity Plus - 60 capsules

SKU: PH590

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Support and Maintain Healthy Brain Function

  • Supports longevity
  • Promotes brain health
  • Enhances cellular health

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Research-Supported Benefits:

Supports Longevity. Fisetin supports longevity by aiding in the removal of senescent cells from the body. (1) Senescent cells, also known as zombie cells, accumulate as we age and contribute to oxidative stress, inflammation and accelerated cellular aging. Research shows that removing senescent cells extends lifespan in animals. (1)

Promotes Brain Health. Research shows that fisetin supplementation may reduce symptoms of age-related brain health decline. (2) Functioning as an antioxidant to reduce neuroinflammation, fisetin has been shown to enhance learning and memory. (2) Additionally, fisetin may prevent brain cell death associated with brain aging. (2)

Enhances Cellular Health. Oxidative stress contributes to cellular damage and accelerated cellular aging. While inflammation and oxidative stress are natural, high levels of oxidative stress and inflammation dramatically reduce longevity. Research shows that fisetin supplementation may reduce oxidative stress and inflammation due to its antioxidant effects, thus promoting longevity. (3)


1. Yousefzadeh MJ, Zhu Y, McGowan SJ, et al. Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine. 2018;36:18-28. doi:10.1016/j.ebiom.2018.09.015

2. Nabavi SF, Braidy N, Habtemariam S, Sureda A, Manayi A, Nabavi SM. Neuroprotective Effects of Fisetin in Alzheimer's and Parkinson's Diseases: From Chemistry to Medicine. Curr Top Med Chem. 2016;16(17):1910-1915. doi:10.2174/1568026616666160204121725

3. Jiang K, Yang J, Xue G, Dai A, Wu H. Fisetin Ameliorates the Inflammation and Oxidative Stress in Lipopolysaccharide-Induced Endometritis. J Inflamm Res. 2021;14:2963-2978. Published 2021 Jul 5. doi:10.2147/JIR.S314130

Supplement Facts
Serving Size: 1 Capsule
Servings Per Container: 60
Amount Per Serving %DV
Proprietary Lifespan Absorption Blend™
Glucomannan, Marshmallow (root), Green Tea extract (leaf) standardized to 95% EGCG, Long Pepper extract 4:1 (fruit), Quercetin, Turmeric extract (root) standardized to 95% curcuminoids
350 mg
Fisetin 125 mg
MCT Oil Powder 25 mg
† Daily Value not established
Rev. 12.23
  • OTHER INGREDIENTS: Vegetable capsule, brown rice flour.
  • DOES NOT CONTAIN: Dairy, egg, soy, wheat, gluten, corn, fish, shellfish, tree nuts, peanuts.
  • SUGGESTED DAILY USE: Take 1 or 2 capsules daily, or as recommended by your healthcare professional.
  • STORAGE: Store in a cool, dry place, away from direct sunlight. Do not use if tamper-evident packaging is broken. KEEP OUT OF REACH OF CHILDREN.
  • CAUTION: Not intended for use if you are pregnant or nursing. Not formulated for use in children. If you have a medical condition or are taking medications, consult with your healthcare professional before using this product. Do not take turmeric if you have a biliary tract obstruction or are taking a steroidal anti-inflammatory such as prednisone.
  • Fisetin is one of the most potent senolytic compounds in existence. Senolytics are defined as nutrients that aid in the removal of senescent cells from the body. As senescent cells accumulate, oxidative stress and longevity decrease.
  • DNA damage accelerates cellular aging. Fisetin may protect against DNA damage and promote DNA repair.
  • Fisetin exhibits powerful antioxidant effects, reducing oxidative stress and inflammation.
  • As we age, our brain cells degrade due to oxidative stress—the buildup of inflammatory compounds called reactive oxygen species. As an antioxidant, fisetin fights off oxidative stress that damages our cells, including neurons. Fisetin also has exhibited beneficial effects on age-related changes in the brain by triggering signaling pathways that promote brain cell growth and neuronal integrity.
  • Unique Formulation. The majority of fisetin products have poor absorption. To help, we added a Proprietary Lifespan Absorption Blend™ to dramatically enhance bioavailability and efficacy and support various aspects of health.
  • Increased Absorption. To further enhance absorption, we included MCT Oil Powder. Adding a fat to the product helps increases the body’s ability to utilize fisetin.
  • Supported for Daily Use. Compared to other fisetin products that are intended to be used 1-2 times per week, our formula is safe enough to be used daily.
  • Quality Manufacturing Practices. All of our products are manufactured in an FDA-registered, GMP-certified facility.
  • Third-Party Tested in the USA. Every batch is third-party tested in US laboratories to ensure the highest quality, purity and potency. Certificates of Analysis are available.

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Better Absorption

Better Absorption

"I used a different brand of Fisetin for senolytic therapy that did not give me the results I was expecting. I tried the ProHealth Longevity brand and got much better results. I believe this was because it was more bioavailable (better absorption)."

- John R., Verified ProHealth Longevity Customer

Customer Reviews

Based on 68 reviews
Gets rid of zombie cells

Prohealth is always top quality. This one’s a must take.

Ronald W.M.

I am 60, and was having trouble remembering some things..., then I found Fisetin and ever since my memory came back!!! 😎

Miguel C.

Fisetin Pro Longevity - 60 capsules

rick r.

Fisetin Pro Longevity - 60 capsules

Brian G.
very good

fisetin is a very powerful senolytic, very important nutrient

Kathy D.

Too early to see or feel any difference.


Very happy with this product!

Virginia G.
It’s all about the quality

Have been taking this supplement from another manufacturer for a few years. Now I am more confident in the quality.

Happy healthy brain

Completes my stack everyday

Jonna R.

Great supplemenr

Frequently asked questions

ProHealth Longevity’s Fisetin Pro Longevity was formulated with a Proprietary Lifespan Absorption Blend™ to dramatically enhance bioavailability and efficacy.
Fisetin is fat soluble, meaning that it is best absorbed with a healthy fat. MCT (medium chain triglycerides) is one of the healthiest fat sources and has been shown to have additional health benefits such as improved energy.
ProHealth’s Fisetin Pro Longevity is formulated to be free of dairy, egg, soy, gluten, wheat or artificial colors or flavors.
No. The product used for the Mayo Clinic study contained only fisetin. Our formulation is combined with other ingredients that should not be consumed at high quantities.
Yes, you can take Fisetin Pro Longevity daily.