Vitamin B-12 - 5000 mcg, 120 lozenges

SKU: PH650

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Introducing ProHealth Longevity's Vitamin B12, a unique combination crafted to harness the synergistic benefits of multiple forms of Vitamin B12. This innovative formula incorporates methylcobalamin, dibencozide, cyanocobalamin, and hydroxycobalamin, each selected for their unique contributions to cellular health, energy metabolism, and overall longevity. While many B12 supplements focus solely on one form of B12, ProHealth Longevity's Vitamin B12 embraces a comprehensive approach, recognizing the diverse roles and benefits offered by each variant. From supporting brain function to enhancing energy levels and combating age-related declines, our formula is designed to optimize B12 status and promote vitality at every stage of life.

  • Plays a crucial role in maintaining cellular integrity by aiding in DNA synthesis and repair
  • Acts as a cofactor in the conversion of carbohydrates, fats, and proteins into usable energy
  • Supports healthy brain aging by aiding in the regeneration of myelin, the protective sheath around nerve fibers
  • Provides mood support by serving as a cofactor in the synthesis of neurotransmitters

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Research-Supported Benefits:

Enhances cellular health. Vitamin B12 is a pivotal player in the synthesis and repair of DNA, critical processes that safeguard cellular integrity. Research has linked Vitamin B12 deficiency to disruptions in DNA synthesis and repair mechanisms, underscoring its importance in maintaining genetic stability. (1) Vitamin B12 offers further cellular protection by supporting telomere maintenance, the protective caps at the ends of chromosomes. Telomeres play a vital role in preserving DNA integrity during cell division, and their maintenance is closely linked to longevity and overall health. By supporting telomere integrity and DNA repair mechanisms, Vitamin B12 contributes to enhanced cellular resilience and longevity, offering comprehensive support for optimal aging.

Heathy heart aging: Vitamin B12 aids in the reduction of homocysteine levels, an amino acid implicated in various forms of DNA damage, including DNA strand breaks. Elevated homocysteine is associated with accelerated cardiovascular aging and increased risk of cardiovascular events. (2) Research shows that increasing vitamin B12 intake may reduce homocysteine levels up to 7%. (3)

Promotes energy production. Vitamin B12 is indispensable for sustaining energy levels, with its deficiency linked to reduced energy production in the body. Through its involvement in synthesizing SAMe, a vital methyl donor nutrient, Vitamin B12 supports mitochondrial function and the generation of ATP, the primary energy currency of cells. As we age, ATP production tends to decline, exacerbated by decreasing levels of Vitamin B12. This decline can lead to age-related fatigue and diminished stamina. Supplementation with Vitamin B12 may offer a solution by replenishing stores and potentially mitigating the decline in ATP production associated with aging.

Promotes Cognitive Health. Vitamin B12 plays a crucial role in maintaining cognitive function, and its deficiency is strongly associated with cognitive decline and memory impairment. (4) Its diverse functions in methylation, neurotransmitter synthesis, and mitochondrial activity are essential for optimal brain health. Notably, Vitamin B12 shows promise in mitigating age-related neurodegeneration by regulating inflammatory processes and protecting against the formation of amyloid beta (Aβ) plaque. (5) Supplementation with Vitamin B12 has potential to alleviate symptoms linked to accelerated brain aging and support overall cognitive well-being.

Supports Mood. Vitamin B12 plays a vital role in the synthesis of essential mood-regulating neurotransmitters, including serotonin and dopamine. Serotonin, known as the "feel-good" neurotransmitter, is synthesized from the amino acid tryptophan in a process facilitated by SAMe, which in turn relies on sufficient levels of Vitamin B12 for optimal function. Similarly, dopamine, a neurotransmitter linked to reward, pleasure, and motivation, also depends on Vitamin B12 for its synthesis. Scientific studies have demonstrated that deficiency in Vitamin B12 correlates with mood dysregulation, contributing to symptoms such as irritability and personality changes. (6)


1. Alzoubi KH, Bayraktar E, Khabour O, Al-Azzam SI. Vitamin B12 protects against DNA damage induced by hydrochlorothiazide. Saudi Pharm J. 2018;26(6):786-789. doi:10.1016/j.jsps.2018.04.005

2. Yan Y, Yin Y, Feng X, et al. Homocysteine aggravates DNA damage by impairing the FA/Brca1 Pathway in NE4C murine neural stem cells. Int J Med Sci. 2020;17(16):2477-2486. Published 2020 Sep 9. doi:10.7150/ijms.49246

3. Maruyama K, S Eshak E, Kinuta M, et al. Association between vitamin B group supplementation with changes in % flow-mediated dilatation and plasma homocysteine levels: a randomized controlled trial. J Clin Biochem Nutr. 2019;64(3):243-249. doi:10.3164/jcbn.17-56

4. Jatoi S, Hafeez A, Riaz SU, Ali A, Ghauri MI, Zehra M. Low Vitamin B12 Levels: An Underestimated Cause Of Minimal Cognitive Impairment And Dementia. Cureus. 2020;12(2):e6976. Published 2020 Feb 13. doi:10.7759/cureus.6976

5. Lam AB, Kervin K, Tanis JE. Vitamin B12 impacts amyloid beta-induced proteotoxicity by regulating the methionine/S-adenosylmethionine cycle. Cell Rep. 2021;36(13):109753. doi:10.1016/j.celrep.2021.109753

6. Sangle P, Sandhu O, Aftab Z, Anthony AT, Khan S. Vitamin B12 Supplementation: Preventing Onset and Improving Prognosis of Depre**ion. Cureus. 2020;12(10):e11169. Published 2020 Oct 26. doi:10.7759/cureus.11169

  • When taken as a supplement, Vitamin B12 is released in the stomach and binds to intrinsic factor, a protein produced by the stomach lining.
  • The Vitamin B12-intrinsic factor complex travels to the small intestine, where it is absorbed into the bloodstream through specialized receptors in the intestinal lining.
  • Once in the bloodstream, Vitamin B12 is transported to various tissues and cells throughout the body, where it exerts its functions.
  • Vitamin B12 plays a crucial role in energy metabolism as a cofactor for the enzyme methionine synthase, which helps convert homocysteine to methionine. Methionine serves as a precursor for S-adenosylmethionine (SAMe), a key methyl donor in cellular reactions.
  • SAMe participates in methylation reactions essential for ATP synthesis, the primary energy currency of cells, thus contributing to overall energy production and vitality.
  • Vitamin B12 helps maintain mitochondrial health and facilitates neurotransmitter synthesis, promoting youthful cognitive functioning and reducing the risk of age-related cognitive decline.
  • Vitamin B12 is crucial for brain health and cognitive function, as it supports mitochondrial function and neurotransmitter synthesis. Mitochondria in brain cells require Vitamin B12 for energy production, which is essential for maintaining neuronal activity and cognitive processes.
Supplement Facts
Serving Size: 1 Lozenge
Servings Per Container: 120
Amount Per Serving %DV
Vitamin B12 5000 mcg 208333%
  Methylcobalamin 1786 mcg 74417%
  Dibencozide 1786 mcg 74416%
  Cyanocobalamin 1071 mcg 44625%
  Hydroxycobalamin 357 mcg 14875%
% Daily Values are based on a 2,000 calorie diet

REV. 12.23

  • OTHER INGREDIENTS: Sorbitol, natural strawberry flavor, rice extract blend, natural color (grape skin extract), and silicon dioxide.
  • DOES NOT CONTAIN: Dairy, egg, soy, wheat, gluten, fish, shellfish, tree nuts, peanuts.
  • SUGGESTED DAILY USE: Take 1 lozenge daily, allow lozenge to fully dissolve under your tongue, then swallow, or as recommended by your healthcare professional.
  • NOTE: Natural color variation may occur. Store in a cool, dry place, away from direct sunlight. Do not use if tamper-evident packaging is broken. KEEP OUT OF REACH OF CHILDREN.
  • CAUTION: Not intended for use if you are pregnant or nursing. Not formulated for use in children. If you have a medical condition or are taking medications, consult with your healthcare professional before using this product.
  • Optimize B12 Status. ProHealth’s Vitamin B12 was specifically formulated to reduce symptoms of age-related health decline associated with low vitamin b12 levels.
  • Unique Combination: Compared to other supplement brands using isolated forms of vitamin b12 ProHealth’s Vitamin B12 contains four different forms of vitamin B12, each selected for their unique contributions to cellular health, energy metabolism, and overall longevity.
  • Quality Manufacturing Practices. All of our products are manufactured in an FDA-registered, GMP-certified facility.
  • Third-Party Tested in the USA. Every batch is third-party tested in US laboratories to ensure the highest quality, purity and potency. Certificates of Analysis are available.

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Frequently asked questions

Vitamin B12 supplements can be taken with or without food, as absorption is generally not significantly affected by food. However, some people may prefer taking it with a meal to reduce the risk of stomach upset.
In certain cases, individuals with specific dietary restrictions, older adults, or those with absorption issues may benefit from B12 supplementation even if they are not deficient. However, it's essential to consult with a healthcare provider for personalized guidance.
There is no specific time of day that is considered optimal for taking vitamin B12. It can be taken in the morning or evening based on personal preference. Some people prefer taking it in the morning to avoid potential interference with sleep.
Vitamin B12 is water-soluble, and excess amounts are usually excreted in urine. However, it's advisable not to exceed recommended dosages, as excessively high levels may have adverse effects.
Vitamin B12 deficiency has been associated with fatigue, and supplementation may be beneficial for individuals with a deficiency. However, fatigue can have various causes, and it's essential to address underlying issues with the guidance of a healthcare professional.