TMG Pro Powder - 250 grams

SKU: PH555

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Regular price $14.80
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A methyl donor that complements NMN and supports heart health and liver detoxification.

  • Supports liver detoxification 
  • Supports cardiovascular health 
  • Promotes healthy homocysteine levels 
  • Supports cellular health 

Research-Supported Benefits:

Supports Cellular Health. TMG is an amino acid that supports the body's methylation processes. Methylation is essential for numerous important cellular functions, including cell division, energy production and producing antioxidants to fight oxidative stress.1

Supports Detoxification. The donation of methyl groups by TMG is critical for healthy liver function and detoxification.1

Supports Cardiovascular Health. TMG may decrease blood levels of homocysteine, an amino acid that is linked to poor heart health and blood vessel damage when elevated.2


1. Arumugam MK, Paal MC, Donohue TM Jr, Ganesan M, Osna NA, Kharbanda KK. Beneficial Effects of Betaine: A Comprehensive Review. Biology (Basel). 2021;10(6):456. Published 2021 May 22. doi:10.3390/biology10060456 

2. McRae MP. Betaine supplementation decreases plasma homocysteine in healthy adult participants: a meta-analysis. J Chiropr Med. 2013;12(1):20-25. doi:10.1016/j.jcm.2012.11.001 doi:10.1016/j.jcm.2012.11.001 

  • Trimethylglycine (TMG), also known as betaine anhydrous, is an amino acid that supports the body's methylation processes. 
  • Methylation is a fundamental biochemical process in which one carbon atom and three hydrogen atoms (CH3) are transferred from one molecule to another. 
  • Methylation is responsible for numerous important bodily functions, such as cell division, cellular energy production, clearing histamine, metabolism, DNA expression (epigenetics), forming neurotransmitters and producing free radical-scavenging antioxidants. 
  • Our bodies contain a “methyl pool” of CH3 that is available whenever needed. As long as we have enough methyl groups stored in the pool, methylation typically is not a problem. However, there are a couple of things that may contribute to the depletion of the body's methyl pool. 
  • MTHFR Variants - Methylenetetrahydrofolate reductase (MTHFR) is a gene with common mutations that can interfere with the methylation process, causing high levels of homocysteine (a known risk factor in heart health conditions) in the blood and low folate levels. Up to 40% of the population may have one or both genetic mutations. 
  • Aging and Epigenetics - Methylation of DNA plays a crucial role in epigenetics, switching different sequences of your genetic material on and off as needed. The body's methylation ability and subsequent DNA expression are known to decline with age. Anti-aging researchers think these changes in DNA expression may be a contributing factor to many age-related diseases. 
  • NMN Supplementation and Methylation Support. When taken as a supplement, NMN may require the use of methyl groups to help facilitate the conversion of NAD+ in your cells, thereby activating sirtuin genes and promoting longevity. Although there is currently no evidence suggesting NMN’s natural methylation process depletes the methyl pool, many top anti-aging experts suggest that safeguarding against methyl depletion may be a wise proactive step to augment your NMN intake. 
Supplement Facts
Serving Size: 1 Level Scoop
Servings Per Container: 250
Amount Per Serving %DV
Trimethylglycine (TMG) (Betaine Anhydrous) 1000 mg
† Daily Value not established
REV. 07.22
  • DOES NOT CONTAIN: Dairy, egg, soy, wheat, gluten, corn, fish, shellfish, tree nuts, peanuts.
  • SUGGESTED DAILY USE: Add 1 scoop to 10 oz of water or other beverage, and drink, or as recommended by your healthcare professional.
  • NOTE: Store in a cool, dry place, away from direct sunlight. This product is very sensitive to moisture/humidity, which may affect product stability. Do not use if tamper-evident packaging is broken. Package filled by weight, not volume.
  • CAUTION: Not intended for use by pregnant or nursing women. Not formulated for use in children. If you have a medical condition or are taking medications, consult with your healthcare professional before using this product. KEEP OUT OF REACH OF CHILDREN

Powdered Form. The powdered form of TMG Pro makes it easy to add to liquids or take in doses that work best for you.

Higher Dose. ProHealth’s TMG Pro contains 1,000 mg of TMG as Betaine Anhydrous, whereas other TMG supplements may contain just 750 mg.

Free of Unwanted Ingredients. TMG Pro doesn’t contain yeast, wheat, gluten, sugar, salt, dairy, eggs, peanuts, tree nuts, fish, shellfish, soy, corn, dye or preservatives.

Quality Manufacturing Practices. All of our products are manufactured in an FDA-registered, GMP-certified facility.

Third-Party Tested in the USA. Every batch is third-party tested in USA laboratories to ensure the highest quality, purity and potency. Certificates of Analysis are available.

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Customer Reviews

Based on 81 reviews
Joshua C.
Good stuff

Really good TMG I use it everyday for about a month and I feel more energy all day

Jason O.

TMG Pro Powder - 250 grams

Delwyn I.
I feel better in general

I’ve noticed I just feel better since using it for the last few weeks.

A safe product with high purity

great product.

brandon h.
this has been amazing

my BP was at 199 and in 1 month (along with exercise) my BP is down in the 130's and occasionally hitting in the 120's. It really has made a difference in how I feel. thank you!

c. s.


Chingchung C.

TMG Pro Powder - 100 grams

Brandon P.

Can’t tell I’m taking it. No better, no worse.


I’ve been taking the combination of the NMN with the TMG for about a month now I’m 58-year-old female. I have seen an increase in my energy level , gained muscle and my endurance is much better . Also, my skin has a more youthful appearance. My husband also started taking this and now is asking to take it every day saying his body feels less achy and he has more energy! I am recommending these products to all of my friends!
Placing another order today

H L.
NMN, Resveratrol, TMG

A key factor driving my decision is that ProHealth's products are manufactured under GMP. The second factor is bulk pricing which is critical once one has decided to make the investment to invest in supplementation to increase the probability of a long health-span.

Frequently asked questions

It’s suggested to take 1 - 3 scoops daily, preferably with food, or as directed by a healthcare practitioner.
This product is very sensitive to moisture/humidity which may affect product stability. Store in a cool dry place. Keep out of reach of children.
TMG is generally considered safe, but some people may experience digestive issues like cramping, bloating, nausea, or diarrhea.