TMG Pro Pure TMG Powder - 500 grams

SKU: PH556

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Regular price $22.20
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A methyl donor that supports heart health and liver detoxification.

  • Supports cardiovascular health*
  • Promotes healthy homocysteine levels*
  • Helps replenish the body's methyl pool*

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Supplement Facts
Serving Size: 1 Level Scoop
Servings Per Container: 500
Amount Per Serving %DV
Trimethylglycine (TMG) (Betaine Anhydrous) 1000 mg
† Daily Value not established
REV. 07.23
  • DOES NOT CONTAIN: Dairy, egg, soy, wheat, gluten, corn, sh, shellsh, tree nuts, peanuts.
  • SUGGESTED DAILY USE: Add 1 scoop to 10 oz of water or other beverage, and drink, or as recommended by your healthcare professional.
  • NOTE: Store in a cool, dry place, away from direct sunlight. This product is very sensitive to moisture/humidity, which may affect product stability. Do not use if tamper-evident packaging is broken. Package filled by
    weight, not volume. KEEP OUT OF REACH OF CHILDREN.
  • CAUTION: Not intended for use by pregnant or nursing women. Not formulated for use in children. If you have a medical condition or are taking medications, consult with your healthcare professional before using this product.

Trimethylglycine (TMG), also known as betaine anhydrous, is an amino acid that supports the body's methylation processes. Methylation is a fundamental biochemical process in which one carbon atom and three hydrogen atoms (CH3) are transferred from one molecule to another. This process is responsible for numerous important bodily functions, such as:

  • Cell division
  • Cellular energy production
  • Clearing histamine
  • Metabolism
  • DNA expression (epigenetics)
  • Forming neurotransmitters
  • Producing free radical scavenging antioxidants

Our bodies contain a “methya l pool” of CH3 that is available whenever needed. As long as we have enough methyl groups stored in the pool, methylation typically is not a problem. However, there are a couple of things that may contribute to the depletion of the body's methyl pool.

  1. MTHFR Variants - Methylenetetrahydrofolate reductase (MTHFR) is a gene with common mutations that can interfere with the methylation process, causing high levels of homocysteine (a known risk factor in heart disease) in the blood and low folate levels. Up to 40% of the population may have one or both genetic mutations.

  2. Aging and Epigenetics - Methylation of DNA plays a crucial role in epigenetics, switching different sequences of your genetic material on and off as needed. The body's methylation ability and subsequent DNA expression is known to decline with age. Anti-aging researchers think these changes in DNA expression may be a contributing factor to many age-related diseases.*

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Customer Reviews

Based on 64 reviews
Teresa B.
TMG Pro Powder

Take with [N][M][N]

Andrea M.
TMG quality is great!!!

This TMG is such a good quality supplement. I've tried others...but felt an immediate difference I'm health with this one. Will re order. I love it!!!

Fred R.
quality products

If your taking [N][M][N] then you should probably be taking a quality TMG product also since [N][M][N] uses methyl groups at a rapid rate and methyl groups are a valuable commodity used throughout your body, most notably in the repair chromosome double strand breaks which is of vital importance. I trust ProHealth to provide a quality TMG product as with most of their other products.


Very good product!

Curt T.

Seems to wokrk

Christopher P.

TMG Pro Powder - 250 grams

Christopher P.

TMG Pro Powder - 250 grams

Deb B.
Fast shipping, good customer service

I’ve just started the supplements so I can’t speak to efficacy but there haven’t been any side effects and they seem to be high quality. Products arrived quickly and I worked with a rep to get some recommendations.

Garry B.

Great product.


I use this in conjunction with multi other products in a full support regiment .
seems to be just fine .

Frequently asked questions

It’s suggested to take 1 - 3 scoops daily, preferably with food, or as directed by a healthcare practitioner.
This product is very sensitive to moisture/humidity which may affect product stability. Store in a cool dry place. Keep out of reach of children.
TMG is generally considered safe, but some people may experience digestive issues like cramping, bloating, nausea, or diarrhea.