Methylfolate Featuring Quatrefolic - 15 mg, 60 capsules

SKU: PH489

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Free Nutritional Advisor

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Supports healthy aging, improves heart health, supports cognitive health

  • Provides methylation support
  • Supports healthy homocysteine levels
  • May help improve fertility and infertility success rates

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Research-Supported Benefits:

Reduces Menopause Symptoms. Hot flashes are a common occurrence in menopausal women. Folate is shown to help reduce hot flashes compared to women don’t supplement. 1

Supports Heart Health. High homocysteine levels can increase the risk of developing heart-related health concerns. Folate has been shown to support healthy homocysteine.2

Supports Cognitive Health. Folate absorption has been shown to decrease with age which can impact cognitive function. Additionally, high homocysteine levels have also been shown to impact brain health. Folate supplementation can encourage cognitive health with age.3-6

Provides Fertility Support. Folate supplementation has been linked with improved fertility outcomes. Additionally, it has been shown to support folate absorption in individuals who have a methylation issue which can impact fertility.7

Supports Healthy Aging. Low levels of folate have been associated with an increased risk of disease. Supplementation can help improve folate levels and reduce the risk of age-related health issues.8, 9


1. Bani Soheila, J Caring Sci 2013

2. Mazza A. et al. Biol Regul Homeost Agents 2016 

3. Rima Obeid R., Herrmann W. FEBS Letters 580, 2006

4. Stover Patrick, Curr Opin Biotechnol 2017 

5. Seshadri S. at al. N Engl J Med 2002  

6. Bottiglieri T, J Neurol Neurosurg Psychiatry 2000 

7. Thaler C.J. 2014 

8. Stover PJ. Modern Nutrition in Health and Disease 2012 

9. Tinelli C, Di Pino A Front. Nutr. 2019 

  • ProHealth's Methylfolate with Quatrefolic® supports a variety of bodily functions including healthy mood, memory, circulation and well-being.* Folic acid and also food folate are not biologically active and need to be converted to the metabolically active 5-methyltetrahydrofolate (5-MTHF) through a multi-steps process where the enzyme methylenetetrahydrofolate reductase (MTHFR) owns a key role.
  • Quatrefolic® provides 5-methyltetrahydrofolate (MTHF), the active form used by the body for DNA regulation and other fundamental metabolic processes. While maintaining the same biological properties of 5-MTHF, Quatrefolic® has been able to increase stability, bioavailability and solubility over other previous folate generations.
Supplement Facts
Serving Size: 1 Capsule
Servings Per Container: 60
Amount Per Serving %DV
Folate (as Quatrefolic® (6S)-5-Methyltetrahydrofolate, glucosamine salt) 25000 mcg DFE (15 mg) 6250%
* Daily Value (DV) based on a 2,000 calorie diet.
REV. 03.24
  • OTHER INGREDIENTS: Microcrystalline cellulose, vegetable capsule.
  • DOES NOT CONTAIN: Dairy, egg, soy, wheat, gluten, corn, fish, shellfish, tree nuts, peanuts.
  • SUGGESTED DAILY USE: Take 1 capsule daily, or as directed by your healthcare professional.
  • CAUTION: Not intended for use if you are pregnant or nursing. Not formulated for use in children. If you have a medical condition or are taking medications, consult with your healthcare professional before using this product. 
  • NOTE: Store in a cool, dry place, away from direct sunlight. Do not use if tamper-evident packaging is broken. KEEP OUT OF REACH OF CHILDREN.

Best Form of Folate. Quatrefolic® is the glucosamine salt of (6s)-5-methyltetrahydrogolate and is comparable to folic acid, the natural form present in the body.

Better Absorption. The active form in Quatrefolic® is more absorbable compared to other brands.

Higher Dosing. Compared to other folate products on the market, Methylfolate contains 3,750% of the Daily Value for folate per serving.

Quality-Manufacturing Practices. All of our products are manufactured in an FDA-registered, GMP-certified facility.

Third-Party Tested in the USA. Every batch is third-party tested in US laboratories to ensure the highest quality, purity and potency. Certificate of Analysis is available.

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Customer Reviews

Based on 24 reviews
Brent R.

After a couple months I noticed more mental clarity.

Helen B.

Methylfolate Featuring Quatrefolic - 15 mg, 60 capsules

Scott M.

Methylfolate Featuring Quatrefolic - 15 mg, 60 capsules

Ivan G.
Great Product for my daughter

My daughter use the product to help her to regulate her emotions, its a great product and the technology is superior than other methyl folate.

Correct folate

You have to make sure your folate source is the right kind and I trust pro health to give me the correct type of folate. This is a good supplement.

Sergio S.

So far so good no issues

Quality Product

Subjectively, I do believe this helps with mood

Julianne E.
Happy with this product

A good quality methyl folate at a reasonable price.

Steve J.

I've had methylfolate prescribed to me for quite a while, and for me, Quatrefolic seems to work best. Ouatrefolic is somewhat hard to find, and the prices here as good as I've found.

Michelle P.

I was reluctant to take 15mg of the quatrofolate but it has helped tremendously. Also the price is the best.

Frequently asked questions

Take 1 capsule daily or as directed by your healthcare professional.
Folate is the natural form of vitamin B9 and folic acid is the synthetic form.