Mitochondria Ignite™ with NT Factor® - 675 mg, 90 tablets - 2 pack


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Restore mitochondrial health to support energy and gut health, fight free radicals and reduce fatigue.

  • Increases energy*
  • Supports mitochondrial function and cellular health
  • Fights free radicals
  • Supports gut health

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Research-Supported Benefits:

Supports Energy Levels. Dysfunctional mitochondria cannot produce energy as effectively. Fats called phosphoglycolipids repair the mitochondrial membrane, reducing free radical damage and optimizing the mitochondria's ability to produce energy. Research shows NT Factor reduces fatigue by 35%. (1)

Supports Mitochondrial Function. Mitochondria Ignite contains “NT Factor,” a proprietary collection of compounds including phosphoglycolipids that support healthy mitochondrial membranes, our body’s main energy hub. It also contains alpha-lipoic acid, magnesium, calcium, phosphorus, creatine monohydrate and more to support mitochondrial activity. (2)

Supports Cellular Health. It contains methylsulfonylmethane (MSM), a sulfur-containing compound that suppresses free radicals produced by mitochondria, as well as alpha-ketoglutarate, an antioxidant compound that stimulates ATP production. (3)

Supports Gut Health. NT Factor contains Bifidobacterium bifidum and Lactobacillus acidophilus, probiotic bacteria that support a healthy gut microbiome and allow phosphoglycolipids to take hold in the gut. NT Factor also contains food-based prebiotic compounds to encourage the growth and survival of the probiotics, including beetroot fiber, blackstrap molasses, leek stem powder, garlic and spirulina. (4)


1. Nicolson GL, Rosenblatt S, de Mattos GF, et al. Clinical Uses of Membrane Lipid Replacement Supplements in Restoring Membrane Function and Reducing Fatigue. Discoveries (Craiova). 2016;4(1):e54. Published 2016 Feb 18. doi:10.15190/d.2016.1

2. Yoon J, Lee H, Lim JW, Kim H. Inhibitory effect of alpha-lipoic acid on mitochondrial dysfunction and interleukin-8 expression in interleukin-1beta-stimulated ataxia teleangiectasia fibroblasts. J Physiol Pharmacol. 2020;71(1):10.26402/jpp.2020.1.15. doi:10.26402/jpp.2020.1.15

3. Butawan M, Benjamin RL, Bloomer RJ. Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement. Nutrients. 2017;9(3):290. Published 2017 Mar 16. doi:10.3390/nu9030290

4. Turroni F, Duranti S, Milani C, Lugli GA, van Sinderen D, Ventura M. Bifidobacterium bifidum: A Key Member of the Early Human Gut Microbiota. Microorganisms. 2019;7(11):544. Published 2019 Nov 9. doi:10.3390/microorganisms7110544

5. Nicolson GL, Ellithorpe RR, Ayson-Mitchell C, et al. Lipid Replacement Therapy with a Glycophospholipid-Antioxidant-Vitamin Formulation Significantly Reduces Fatigue Within One Week. JANA. 2010;13(1):26-31.

6. Agadjanyan M, Vasilevko V, Chochikyan A, et al. Nutritional Supplement (NT Factor™) Restores Mitochondrial Function and Reduces Moderately Severe Fatigue in Aged Subjects. Journal of Chronic Fatigue Syndrome. 2003;11(3):23-36, DOI: 10.1300/J092v11n03_03

7. Nicolson GL, Ellithorpe R. Lipid Replacement and Antioxidant Nutritional Therapy for Restoring Mitochondrial Function and Reducing Fatigue in Chronic Fatigue Syndrome and Other Fatiguing Illnesses. Journal of Chronic Fatigue Syndrome. 2006;13(1):57-68. DOI: 10.1300/J092v13n01_06

8. Cadenas E, Davies KJ. Mitochondrial free radical generation, oxidative stress, and aging. Free Radic Biol Med. 2000;29(3-4):222-230. doi:10.1016/s0891-5849(00)00317-8

9. Asadi Shahmirzadi A, Edgar D, Liao CY, et al. Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan in Aging Mice. Cell Metab. 2020;32(3):447-456.e6. doi:10.1016/j.cmet.2020.08.004

10. Finkel T, Menazza S, Holmström KM, et al. The ins and outs of mitochondrial calcium. Circ Res. 2015;116(11):1810-1819. doi:10.1161/CIRCRESAHA.116.305484

11. Villa-Bellosta R. Dietary magnesium supplementation improves lifespan in a mouse model. EMBO Mol Med. 2020;12(10):e12423. doi:10.15252/emmm.202012423

12. Nishi Y, Fujimoto S, Sasaki M, et al. Role of mitochondrial phosphate carrier in metabolism-secretion coupling in rat cell line INS-1. Biochem J. 2011;435(2):421-430. doi:10.1042/BJ20101708

13. Hansen SH, Andersen ML, Cornett C, Gradinaru R, Grunnet N. A role for taurine in mitochondrial function. J Biomed Sci. 2010;17 Suppl 1(Suppl 1): S23. Published 2010 Aug 24. doi:10.1186/1423-0127-17-S1-S23

14. Heidari R, Ghanbarinejad V, Mohammadi H, et al. Mitochondria protection as a mechanism underlying the effects of glycine in mice. Biomed Pharmacother. 2018;97:1086-1095. doi:10.1016/j.biopha.2017.10.166

  • A proprietary nutrient complex called NT Factor® supports energy and mitochondrial function with phosphoglycolipids, probiotic bacteria, prebiotic foods, vitamins, minerals and more.
  • Clinical trials have shown that NT Factor® can actually support the repair of damaged cell membranes - in effect reducing the cells' biological age and restoring mitochondrial ability to generate energy.
  • The NT Factor formulation is specially designed so that the phosphoglycolipids match the human cell membrane and are not digested but instead are able to get into the wall of the GI tract intact. Once there, they go to work repairing any damage in the cell membrane.
  • Phosphoglycolipids have their own energy supply, each containing a battery-like structure with a positive and negative charge. Because of this, when this type of lipid is laid against a cell membrane, it naturally forces itself into the membrane. Therefore, phosphoglycolipids require none of the patient's energy to get into the body—an important feature for individuals who are already severely fatigued.
  • NT Factor enables all other nutrients to work better because it repairs the cell membranes. This improves the body's ability to take in nutrition and get rid of waste more effectively.
  • In addition to being a rich source of phosphoglycolipids, NT Factor was also formulated to provide both friendly bacteria (Bifido and Lactobacillus bacterium) needed to keep the gastrointestinal tract functioning properly, and the growth media necessary to feed the good bacteria so they can colonize.
How NT Factor Helps Reduce Fatigue

When a person experiences chronic fatigue, whether it's due to an illness or aging, the mitochondria are only operating at 40 to 60 percent of capacity. There is not enough energy left to drive all of the important functions needed - which can include thinking, movement, muscular activity and other necessary activities.

Mitochondria are like little batteries within our cells that provide the energy our bodies need. Certain health issues can lead to the mitochondrial membrane being damaged, which causes it to leak. When the mitochondria become leaky, they cannot generate energy because a very important component of that energy-driving system is that the membranes provide insulation for the mitochondria. A good comparison is the insulation surrounding a battery. If you take the insulation off of the battery, it runs down very quickly. The same thing happens with the mitochondria.

Mitochondria are made up of an inner and outer membrane. The inner membrane is where food, water and oxygen are converted to adenosine triphosphate (ATP), which supplies energy to all your cells. It's also where the free radicals that drive aging and illness are produced.

As the phosphoglycolipids in NT Factor are pushed into the mitochondria to repair the membrane, the production of free radicals that damage the membrane is slowed down or stopped. Thus, phosphoglycolipids optimize the mitochondria's ability to produce energy.

Multiple tests done with both moderately and severely fatigued patients have shown that NT Factor can support reduction of fatigue by as much as 45 percent and increases in mitochondrial function of 35 percent. (5-7)

Supplement Facts
Serving Size: 2 Tablets
Servings Per Container: 45
Amount Per Serving %DV
Calcium (as calcium carbonate, dicalcium phosphate, calcium pyruvate, calcium borogluconate, calcium ascorbate, d-calcium pantothenate) 160 mg 12%
Phosphorous (as di-calcium phosphate) 50 mg 4%
Magnesium (as magnesium oxide) 50 mg 12%
Carnitine Fumarate 140 mg
Creatine Monohydrate 100 mg
Pantethine (a Coenzyme A Precursor) 50 mg
NT Factor® Proprietary Blend: NT Factor Lipids® (Pat.No. 8,877,239), Fructo-oligosaccharides, Rice Bran Extract, Opti MSM®, Bromelain, Sulfur, Pantethine, Inositol, L-Arginine, L-Glycine,Taurine, Alpha Lipoic Acid, Garlic, Spirulina, Beet Root Fiber, Bifidobacterium bifidum, Leeks Stem powder, Lactobacillus acidophilus, Blackstrap Molasses, Boron. 1350 mg
† Daily Value not established
** Daily Values are based on a 2,000 calorie per day diet

NT Factor® and NT Factor Lipids® are registered trademarks of Nutritional Therapeutics, Inc.


NT Factor® is a nutrient complex extracted and prepared using proprietary processes. It is composed only of food and food components listed as: Phosphoglycolipids - includes polyunsaturated phosphatidylcholine, glycolipids, and other polyunsaturated phosphatidyl nutrients. Bifido and Lactobacillus Bacterium - freeze-dried and microencapsulated in a state of suspended animation with the potential to form healthy micro flora colonies. Growth Media - foods and bacteria growth factors to support microflora colonies including rice bran extract, arginine, beet root fiber, black strap molasses, glycine, magnesium sulfate, para-amino benzoate, leek, pantethine (bifido growth factor), taurine, garlic, calcium borogluconate, artichoke, potassium citrate, calcium sulfate, spirulina, bromelain, natural vitamin E, calcium ascorbate, alpha-lipoic acid, oligosaccharides, B-6, niacinamide, riboflavin, inositol, niacin, calcium pantothenate, thiamin, B-12, folic acid.

    • OTHER INGREDIENTS: Vegetable stearic acid, vegetable stearate, croscarmellose sodium, microcrystalline cellulose, and pharmaceutical glaze.
    • DOES NOT CONTAIN: Milk, egg, peanuts, shellfish, tree nuts, wheat, yeast, gluten.
    • CONTAINS: Soy
    • SUGGESTED DAILY USE: Take 2 tablets with food up to 3 times per day, or as recommended by your healthcare professional.
    • CAUTION: Not intended for use if you are pregnant or nursing. Not formulated for use in children. If you have a medical condition or are taking medications, consult with your healthcare professional before using this product.
    • NOTE: Store in a cool, dry place, away from direct sunlight. Do not use if tamper-evident packaging is broken. KEEP OUT OF REACH OF CHILDREN.

    Unique Formulation. ProHealth’s Mitochondrial Ignite with NT Factor® is a unique and proprietary blend of nutrients, fats and compounds that support mitochondrial function to reduce fatigue and support healthy energy levels.

    Ingredients Comparable to Human Cell Membranes. The phosphoglycolipids in NT Factor are a unique extract that matches human cell membranes. This is why they are able to push themselves into the cell membranes.

    Natural. NT Factor is natural to the human body. Not all natural products are - they may be a natural plant source, for example, but not necessarily natural to the human body. NT Factor is composed only of food and food components.

    Unoxidized Lipids. Many food sources and products purchased from health stores contain oxidized lipids, which cannot be used to repair cell membranes. The phosphoglycolipids in NT Factor are unoxidized lipids. Additionally, NT Factor's phosphoglycolipids are protected so they are not oxidized and destroyed by the digestive process.

    Supported by Clinical Studies. NT Factor is the only product proven in clinical trials to support the repair of damaged cell membranes. NT Factor is proven in clinical trials to successfully support reduced fatigue. NT Factor has supported benefits in fatigue trials for the large majority of those who take it.

    Quality Manufacturing Practices. All of our products are manufactured in an FDA-registered, GMP-certified facility.

    Third-Party Tested in the USA. Every batch is third-party tested in US laboratories to ensure the highest quality, purity and potency. Certificates of Analysis are available.

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    Customer Reviews

    Based on 68 reviews
    John C.
    My Long Healing Journey And Mitochondria Ignite

    When I first encountered Mitochondria Ignite, it was in the mid-2000's. It didn't work for me, since I was still heavily toxic from chemotherapy, et al. Recently, I've started taking it again after using CBD oil to cleanse my body. Mitochondria Ignite has definitely had an effect on my energy level, sometimes good, sometimes bad, which means it's healing my cells, or so I suspect. A few months ago when it went out of stock and I wasn't able to take it, I definitely felt worse. Now that I'm on it again, I expect things to get better -- we'll see.

    Excellent stuff

    Mitochondria Ignite has become my daily go-to, providing a sustained boost that keeps me focused and energized throughout the day.

    Valeria K.

    I live in Mexico, so because of beurocratic obstacles it took very long for your supplement to reach me. I am taking it for 10 days only, so it is too early to evaluate its effectiveness. For now I do not see any difference in my energy level. With best wishes. Valeria

    Arthur G.

    I've been using mitochondria ignite for over a month now. My stomach feels a lot better. 🫡

    wm l.
    Mitochondria Ignite™

    good product.
    Brain operation is more flexible

    P. J.
    Nerves feel more energized

    I have been taking Mitochondria Ignite for several years now. A couple of times I stopped taking it for awhile, and I did not have as much energy. My nerves feel better when I take it too.

    Susan A.

    Gives me more energy and battery power to get up and do things. When I ran out, I really felt the difference! I hope one day it can be available in the UK. Ruth, UK

    Ricky D.
    Good energy

    I thought it wasn't going to do anything until about 10 days it gave me really good energy i was impressed at the way it felt right at the last of the bottle I think ill try again it wasn't like coffee.

    Kok C.K.
    A definitely good choice for anti-aging

    After consuming the tablets everyday, I get energized doing my routine exercise. It is really amazing that I feel easier to run the same distance than before. I'm also able to lift heavier weight in gym. It makes me fell young at all times. Highly recommended for boosting energy and promoting anti-aging.

    Julie C.
    wonderful product !

    Mitochondria IGNITE gives my son more energy for his muscles. This is such a wonderful product !

    Frequently asked questions

    Mitochondria Ignite with NT Factor may be taken with or without food. The blend of probiotics and growth media present in NT Factor provides all of the co-factors needed for absorption.
    No. Mitochondria Ignite does not contain corn or corn byproducts.
    Yes, the soy is non-GMO from U.S. sources.
    NT Factor® is a unique and proprietary blend of nutrients, fats called phosphoglycolipids, friendly bacteria and prebiotic compounds that support mitochondrial function to reduce fatigue and support healthy energy levels.