Twelve minutes of cardio impacts 80% of circulating metabolites, improving cardiometabolic health. Brief bouts of exercise benefit insulin resistance, oxidative stress, inflammation, and longevity pathways.

In this study, middle-aged animals eating Mediterranean diets experienced better resilience to stress, lower cortisol, and slower nervous system aging than animals consuming a typical Western diet.

Researchers identify chronic inflammation, senescent cells, and activation of the protein CD38 as a driver of NAD+ decline, the crucial coenzyme needed for healthy metabolism, aging, and DNA repair.

The HDAC6 inhibitor Tubastatin A is a promising target to delay or treat osteoarthritis, reversing damage caused by HDAC6 overexpression, protecting the extracellular matrix and chondrocytes.