Full Spectrum Apigenin - 500 mg, 60 capsules

SKU: PH621

Sale price

Regular price $45.74
( / )

Also Available:

Free Nutritional Advisor

Free Nutritional Advisor

Apigenin is a powerful flavonoid that helps fight the signs of aging and supports numerous aspects of health.

  • Supports longevity by inhibiting CD38, a harmful enzyme that decreases NAD+ levels
  • Provides antioxidant benefits
  • Supports mood, heart and brain health
  • Enhances sleep quality

View Certificate of Analysis »

Research-Supported Benefits:

Supports Longevity.  Apigenin has been shown to inhibit CD38, a harmful enzyme that decreases NAD+ levels. Inhibition of CD38 helps keep NAD+ levels stable to support healthy aging processes and reduce the risk of premature aging. (1,2)
Provides Antioxidant Benefits. The aging process and risk of age-related health issues can be accelerated by free radicals. Antioxidants are a way to help curb free-radical activity. Apigenin’s antioxidant properties have been proven to fight free-radical damage, tackle oxidative stress, reduce signs of premature aging and reduce the risk of age-related health concerns. (3)

Promotes Heart Health. Aging can cause changes to heart function and blood vessels. In fact, adults over the age of 65 are more likely to suffer from a heart event compared to younger people. The most common sign of heart health aging is a change to the arteries, which can become stiff, harden and fill with fat deposits leading to high blood pressure.  Apigenin can help decrease certain heart health blood markers, reduce blood pressure and improve blood circulation. (4)

Enhances Sleep Quality. Poor sleep quality is associated with accelerated aging. Research indicates that apigenin has a positive effect on sleep. (5,6)

Supports Brain Health. With aging comes symptoms of brain decline such as impaired memory. Apigenin helps protect the brain from damage caused by oxidative stress, which can lead to a decline in cognitive function. Apigenin may increase cognitive function, improve memory formation and enhance overall mental clarity. (7)

Supports Mood. Studies have shown that apigenin can help reduce feelings of worry, overwhelm, and stress, resulting in improved mood. (8)

Aids in Testosterone Maintenance. Apigenin may support healthy testosterone levels and prevent the decrease in testosterone commonly seen in aging males. (9)


1. Escande C, Nin V, Price NL, et al. Flavonoid apigenin is an inhibitor of the NAD+ ASE CD38: Implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome. Diabetes. Published April 2013. Accessed February 24, 2023.

2. M; AAZAA. Mitigating effects of apigenin on edifenphos-induced oxidative stress, DNA damage and apoptotic cell death in human peripheral blood lymphocytes. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. Accessed February 24, 2023.

3. Zhang K, Song W, Li D, Jin X. Apigenin in the regulation of cholesterol metabolism and protection of blood vessels. Experimental and therapeutic medicine. Published May 2017. Accessed February 24, 2023.

4. Gao, H. L., Yu, X. J., Hu, H. B., Yang, Q. W., Liu, K. L., Chen, Y. M., Zhang, Y., Zhang, D. D., Tian, H., Zhu, G. Q., Qi, J., & Kang, Y. M. (2021). Apigenin Improves Hypertension and Cardiac Hypertrophy Through Modulating NADPH Oxidase-Dependent ROS Generation and Cytokines in Hypothalamic Paraventricular Nucleus. Cardiovascular toxicology, 21(9), 721–736.

5. Zhang, K., Song, W., Li, D., & Jin, X. (2017). Apigenin in the regulation of cholesterol metabolism and protection of blood vessels. Experimental and therapeutic medicine, 13(5), 1719–1724.

6. Kim, J. W., Kim, C. S., Hu, Z., Han, J. Y., Kim, S. K., Yoo, S. K., Yeo, Y. M., Chong, M. S., Lee, K., Hong, J. T., & Oh, K. W. (2012). Enhancement of pentobarbital-induced sleep by apigenin through chloride ion channel activation. Archives of pharmacal research, 35(2), 367–373.

7. Dourado, N. S., Souza, C. D. S., de Almeida, M. M. A., Bispo da Silva, A., Dos Santos, B. L., Silva, V. D. A., De Assis, A. M., da Silva, J. S., Souza, D. O., Costa, M. F. D., Butt, A. M., & Costa, S. L. (2020). Neuroimmunomodulatory and Neuroprotective Effects of the Flavonoid Apigenin in in vitro Models of Neuroinflammation Associated With Alzheimer's Disease. Frontiers in aging neuroscience, 12, 119.

8. Amsterdam JD, Li Y, Soeller I, Rockwell K, Mao JJ, Shults J. A randomized, double-blind, placebo-controlled trial of oral matricaria recutita (chamomile) extract therapy for generalized anxiety disorder. Journal of clinical psychopharmacology. Published August 2009. Accessed February 24, 2023.

9. Li W, Pandey AK, Yin X, et al. Effects of apigenin on steroidogenesis and steroidogenic acute regulatory gene expression in mouse leydig cells. The Journal of nutritional biochemistry. Published March 2011. Accessed February 24, 2023.

10. Li, B. S., Zhu, R. Z., Lim, S. H., Seo, J. H., & Choi, B. M. (2021). Apigenin Alleviates Oxidative Stress-Induced Cellular Senescence via Modulation of the SIRT1-NAD[Formula: see text]-CD38 Axis. The American journal of Chinese medicine, 49(5), 1235–1250.

11. Ogura, Y., Kitada, M., Xu, J., Monno, I., & Koya, D. (2020). CD38 inhibition by apigenin ameliorates mitochondrial oxidative stress through restoration of the intracellular NAD+/NADH ratio and Sirt3 activity in renal tubular cells in diabetic rats. Aging, 12(12), 11325–11336.

12. Salehi, B., Venditti, A., Sharifi-Rad, M., Kręgiel, D., Sharifi-Rad, J., Durazzo, A., Lucarini, M., Santini, A., Souto, E. B., Novellino, E., Antolak, H., Azzini, E., Setzer, W. N., & Martins, N. (2019). The Therapeutic Potential of Apigenin. International journal of molecular sciences, 20(6), 1305.

Supplement Facts
Serving Size: 2 capsules
Servings Per Container: 30
Amount Per Serving %DV
Natural Apigenin (Apium graveolen) Extract 98%
500 mg
Organic Parsley Powder (Petroselinum crispum)
700 mg
Piperine (Piper nigrum) Black Pepper Extract 95%
7 mg
† Daily value not established
Rev. 02.23
  • Other Ingredients: Hydroxypropyl methylcellulose (HPMC) Capsule.
  • Does Not Contain: Wheat, gluten, nuts, soy, sesame, dairy, fish, shellfish, eggs, or tree nuts.
  • Suggested Daily Use: Take 2 capsules daily with a meal.
  • Caution: Consult a medical professional before use. Do not use if you are pregnant, nursing or under the age of 18 years old.
  • Keep out of reach of children.
  • As you age, levels of NAD+, a key nutrient in the body, naturally declines at a rate of 1% per year. Reduced levels of NAD+ contribute to a variety of age-related health concerns including impaired heart health, reduced energy and cognitive decline. Additionally, inflammation, often from unhealthy lifestyle factors, triggers the production of the enzyme CD38, which suppresses NAD+ levels. This further accelerates premature aging and age-related health concerns. Apigenin is proven to help interfere with these processes, supporting overall health and longevity.

  • Natural apigenin is the purest form of apigenin and provides longevity and health-supporting benefits.

  • Organic parsley powder promotes the full-spectrum benefits of apigenin, enhancing efficacy due to the naturally containing apigenin co-factors it contains.

  • Piperine is added to enhance the absorption of the apigenin. Increased absorption can translate into increased efficacy of the product.
Unique Formulation. Compared to the majority of apigenin products on the market that contain only one ingredient, we included natural apigenin, organic parsley powder and piperine. This combination provides a variety of benefits to support the health needs of those over the age of 40, as well as enhance the absorption of the product.

Full-Spectrum Apigenin. Other apigenin products on the market often contain the isolated form of apigenin. This lower-quality version only provides 1-2 health benefits. ProHealth’s Full Spectrum Apigenin contains full-spectrum apigenin to support numerous areas of health and aging. Full spectrum means the entire plant and the full range of flavonoids were used.

Natural Apigenin. The majority of products on the market contain the synthetic version of apigenin. ProHealth’s Full Spectrum Apigenin contains natural apigenin for the highest-quality, most natural version.

Organic Parsley Powder. ProHealth’s Full Spectrum Apigenin contains 700 mg of organic parsley powder, a natural source of apigenin and other co-factors that enhance the biological effects of apigenin.

Better Dosing. Compared to the majority of products on the market with lower doses, Full Spectrum Apigenin contains dosing supported by research: 500 mg natural apigenin, 700 mg organic parsley powder and 7 mg piperine.

Quality-Manufacturing Practices. All of our products are manufactured in an FDA-registered, GMP-certified facility.  

Third-Party Tested in the USA. Every batch is third-party tested in US laboratories to ensure the highest quality, purity and potency. Certificates of Analysis are available.
Benefits +
How it Works +
How Ours is Better +
Label Information +

Customer Reviews

Based on 14 reviews
Maha L.
It works wonders when taking sparingly...

I have found that taking an Apigenin dose daily does not work for me. It even leads me to waking up tired. However, when I take once a week, it works wonders allowing me to only wake up once during the night (instead of 4 or 5 times). And I say "YES" to that!

Terra B.

I’m feeling more energy during the day and sleeping better at night.

Adam U.
Enhance memory, sleep and testosterone levels

This supplement provides many benefits such as enhanced cognitive function and improved ability to fight oxidative stress. all in all a great addition to anyone’s arsenal

The right Health insurance!

I feel more confident that I am combatting harmful cells and living my best life every day by taking the full spectrum Apigem.

Eric V.
Apigenin and [N] [M] [N]

There is a lot of research being done on [N] [M] [N] right now. It has become the cornerstone for a longevity regimen. Simply put, Apigenin helps [N] [M] [N] work, and I can tell a difference.

John S.

Full Spectrum Apigenin (500 mg per 2-capsule serving, 60 capsules) by ProHealth Longevity

Olena P.
I feel much calmer!

I took a first bottle and noticed my reaction to stress changed. I didn't even understand how stressed I was before I started taking apigenin. I bought a second bottle and it is just gradually bringing me on a next level of calmness. No anxiety any more, I feel better when driving or communicating with people,what used to trigger me - now seems just to be a normal course of the life. My communication at work and family got better. It definitely worth the money! I will buy again

Raymond D.
a keeper

I noticed positive results right away ..this is a keeper in my daily supplement list.. I take it daily before bed along with s acetyl glutathione and glycine

High Dose & Full Spectrum!

I love the high dose and the fact that it's full spectrum. I take it with [N] [M] [N] to protect NAD+. Super high quality, super high potency, super high dose.

Joe C.

Full Spectrum Apigenin (500 mg per 2-capsule serving, 60 capsules) by ProHealth Longevity

Frequently asked questions

Yes, apigenin increases NAD+ levels by reducing the activity of the CD38 enzyme, which decreases NAD+.
We recommend taking 2 capsules daily, preferably with a healthy fat-containing meal.