Phosphatidylserine - 300 mg per serving, 120 capsules

SKU: PH641

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Phosphatidylserine (PS) is a phospholipid naturally found in cell membranes, with high concentrations in the brain. It is essential for cognitive function, as it supports neurotransmitter activity, helps maintain cellular membrane integrity, and plays a role in memory and stress response regulation.

  • Enhances cognitive function and reduces symptoms of brain aging
  • Promotes cellular health by aiding in the maintenance of cell membrane fluidity and stability
  • Aids in stress management and mood regulation by promoting neurotransmitter balance

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Research-Supported Benefits:

Enhances Brain Health. Studies suggest that phosphatidylserine supplementation may enhance memory, concentration, and cognitive performance, particularly in individuals with age-related cognitive decline or memory problems. (1)

Promotes Cellular Health. Phosphatidylserine is a key component of cell membranes that aids in the maintenance of membrane integrity, contributing to overall cellular health. (2)

Aids in Stress Management. Phosphatidylserine has been studied for its ability to reduce cortisol levels in response to stress. Cortisol is a stress hormone that, when elevated, can interfere with sleep quality and make it difficult to fall asleep or stay asleep. By reducing cortisol levels, phosphatidylserine may help lower stress, making it easier to achieve restful sleep. (3)

Regulates Mood. Phosphatidylserine is involved in the synthesis and release of neurotransmitters, such as serotonin and dopamine, which play integral roles in mood regulation. By modulating the levels and activity of these neurotransmitters, phosphatidylserine may contribute to an improved mood. (4)


1. Kato-Kataoka A, Sakai M, Ebina R, Nonaka C, Asano T, Miyamori T. Soybean-derived phosphatidylserine improves memory function of the elderly Japanese subjects with memory complaints. J Clin Biochem Nutr. 2010;47(3):246-255. doi:10.3164/jcbn.10-62

2. Vance JE, Tasseva G. Formation and function of phosphatidylserine and phosphatidylethanolamine in mammalian cells. Biochim Biophys Acta. 2013;1831(3):543-554. doi:10.1016/j.bbalip.2012.08.016

3. Komori T. The Effects of Phosphatidylserine and Omega-3 Fatty Acid-Containing Supplement on Late Life Depression. Ment Illn. 2015;7(1):5647. Published 2015 Apr 1. doi:10.4081/mi.2015.5647

4. Benton D, Donohoe RT, Sillance B, Nabb S. The influence of phosphatidylserine supplementation on mood and heart rate when faced with an acute stressor. Nutr Neurosci. 2001;4(3):169-178. doi:10.1080/1028415x.2001.11747360

5. Glade MJ, Smith K. Phosphatidylserine and the human brain. Nutrition. 2015;31(6):781-786. doi:10.1016/j.nut.2014.10.014

6. Ma X, Li X, Wang W, Zhang M, Yang B, Miao Z. Phosphatidylserine, inflammation, and central nervous system diseases. Front Aging Neurosci. 2022;14:975176. Published 2022 Aug 3. doi:10.3389/fnagi.2022.975176

  • Phosphatidylserine is a nutrient that your body synthesizes in very small amounts but can be obtained from certain dietary sources such as fish, meat, soy, and sunflower.
  • As you age, levels of phosphatidylserine may naturally decline, potentially impacting various aspects of health, including cognitive function, mood, and stress management. (5)
  • Phosphatidylserine is absorbed in the intestines and can be transported to different cells throughout the body. It helps to maintain the structure and function of cell membranes.
  • Once incorporated into cell membranes, phosphatidylserine contributes to cellular health and function by supporting membrane fluidity and influencing various cellular processes.
  • Phosphatidylserine is known to enhance neurotransmitter activity, maintain appropriate communication between brain cells, and support the health of nerve cells.
  • Studies have suggested that phosphatidylserine supplementation can have a positive impact on cognitive function, especially in individuals experiencing age-related cognitive decline or memory issues. (6)
Supplement Facts
Serving Size: 2 Capsules
Servings Per Container: 60
Amount Per Serving %DV
Phosphatidylserine (from sunflower) 300 mg
† Daily Value not established

REV. 10.23

  • OTHER INGREDIENTS: Vegetable capsule, rice hulls.
  • DOES NOT CONTAIN: Dairy, egg, soy, wheat, gluten, fish, shellfish, tree nuts, peanuts.
  • SUGGESTED DAILY USE: Take 2 capsules per day, or as recommended by your healthcare professional.
  • NOTE: Store in a cool, dry place, away from direct sunlight. Do not use if tamper evident seal is broken or missing. KEEP OUT OF REACH OF CHILDREN.
  • CAUTION: Not intended for use by pregnant or nursing women. Not formulated for use in children. If you have a medical condition or are taking medications, consult with your healthcare professional before using this product.
  • Unique Formulation. Compared to the majority of phosphatidylserine products on the market that are sourced from soy (90% of soy in the US is genetically modified), ProHealth’s Phosphatidylserine is sourced from sunflower, which tends to be better tolerated especially for those with soy allergies.
  • Effective Dosing: ProHealth's Phosphatidylserine contains a clinically effective dose of 300 mg of phosphatidylserine per serving.
  • Quality Manufacturing Practices. All of our products are manufactured in an FDA-registered, GMP-certified facility.
  • Third-Party Tested in the USA. Every batch is third-party tested in US laboratories to ensure the highest quality, purity and potency. Certificates of Analysis are available.

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Customer Reviews

Based on 3 reviews
Karen W.

I’m in my first month of using Phosphatidylserine and am looking very excitedly ahead to feel the fantastic benefits of this product! So far I am feeling more youthful and energetic!

Jina B.

I've noticed that I've been sleeping better and waking up less during the night since starting Phosphatidylserine, which is huge. With consistent use I look forward to some of the long-term benefits like reduction in stress hormones and better use of neurotransmitters that my body produces.

Clinically studied dosing!

This product is sourced uniquely from sunflowers, making it a great option for individuals who prefer to avoid soy-based products.

Frequently asked questions

While there is no specific time of day that is considered optimal for taking phosphatidylserine, many individuals prefer taking phosphatidylserine in the evening to reduce stress and facilitate restful sleep.
No. ProHealth’s Phosphatidylserine is sourced from sunflower, not soy.