B-12 Extreme™ - 35 mg, 30 lozenges

SKU: PH314

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Regular price $44.87
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High-potency vitamin B12 supports energy, cellular health, detoxification and mental acuity.

  • For energy, mental acuity, cellular health, liver support and detoxification
  • Provides high doses of all four forms of vitamin B12
  • Includes the only two biologically active forms of vitamin B12 without requiring conversion (methylcobalamin and dibencozide).

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Supports Energy Levels. Dibencozide (also known as adensylcobalamin) metabolizes essential fatty acids to produce more energy. As a biologically active form of B12, this dibencozide reacts with cells to provide muscles and nerves with bursts of energy. Research shows that people with vitamin B12 deficiency are more likely to experience severe fatigue.1

Supports Cellular Health and DNA. Vitamin B12 plays a significant role in red blood cell and DNA synthesis. Methylcobalamin plays a vital part in cell growth, while cyanocobalamin creates enzymes to help the body with blood formation, cell reproduction and tissue synthesis.2

Supports Healthy Cognitive Function. Methylcobalamin is important for the central nervous system. This form of vitamin B12 helps to promote healthy homocysteine levels, increase the brain's focus and mental clarity, and supports the spinal cord's function.3,4

Supports Detoxification and Liver Health. The second phase of liver detoxification uses vitamin B12 to transform toxic intermediary compounds into harmless compounds to be excreted. Cyanocobalamin, the most common of the cobalamins, becomes metabolically active in your liver, and the hydroxo version helps support overall detoxification.5


1. Huijts M, Duits A, Staals J, van Oostenbrugge RJ. Association of vitamin B12 deficiency with fatigue and depression after lacunar stroke. PLoS One. 2012;7(1):e30519. doi:10.1371/journal.pone.0030519

2. Allen LH. Vitamin B-12. Adv Nutr. 2012;3(1):54-55. doi:10.3945/an.111.001370

3. Tardy AL, Pouteau E, Marquez D, Yilmaz C, Scholey A. Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence. Nutrients. 2020;12(1):228. Published 2020 Jan 16. doi:10.3390/nu12010228

4. Garrod MG, Green R, Allen LH, et al. Fraction of total plasma vitamin B12 bound to transcobalamin correlates with cognitive function in elderly Latinos with depressive symptoms. Clin Chem. 2008;54(7):1210-1217. doi:10.1373/clinchem.2007.102632

5. Hodges RE, Minich DM. Modulation of Metabolic Detoxification Pathways Using Foods and Food-Derived Components: A Scientific Review with Clinical Application. J Nutr Metab. 2015;2015:760689. doi:10.1155/2015/760689

  • Four forms of vitamin B12 in high doses work together to support cellular health, energy, DNA health, cognitive function and liver detoxification.
  • Methylcobalamin helps promote healthy homocysteine levels and helps increase the brain's focus and clarity, and the spinal cord's function.
  • Dibencozide, also known as Adensylcobalamin, metabolizes essential fatty acids to produce more energy. As a biologically active form of B-12, this B-12 lozenge reacts with cells to provide muscles and nerves with bursts of energy.
  • Cyanocobalamin, the most common of the cobalamins, becomes active in your liver, creating enzymes to help the body with blood formation, cell reproduction, iron utilization, and tissue synthesis, while aiding the digestion and absorption of foods.
  • Hydroxo- (one of the three essential cobalamins that make up the vitamin B-12 complex) helps support overall detoxification. Contained in ProHealth's sublingual B12 supplement, it also assists with methylation and energy production.
  • Most Potent B-12 Supplement. ProHealth’s B-12 Extreme is the most potent vitamin B12 supplement on the market.
  • Active Forms of B-12. Compared to other B-12 products on the market that usually contain one form of B-12, ProHealth’s B-12 Extreme provides all four forms of vitamin B12, including the only two biologically active forms of B12, methylcobalamin and dibencozide.
  • Quality Manufacturing Practices. All of our products are manufactured in an FDA-registered, GMP-certified facility.
  • Third-Party Tested in the USA. Every batch is third-party tested in US laboratories to ensure the highest quality, purity and potency. Certificates of Analysis are available.
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This Product is Superior

This Product is Superior

“I love taking this supplement for my B-12 as I have tried others and this product is superior (I have even tried patches) - I highly recommend it!!!”

- Sheryl S., Verified ProHealth Longevity Customer

Customer Reviews

Based on 71 reviews
Barbara K.
Great product

I use thiese 3 to 7 times a week. I am recovering from B12 deficiency

Linda M.

Excellent source of energy

Alice F.
works quick

I was surprised that I began feeling less fatigued after only a week of using. Taste is fruity and not bad. It takes a bit longer to dissolve than I'd like - more than a minute. My only complaints are the cost and difficulty punching out of the holder.

Deborah R.
The best B-12 I have used

Very effective results for as I have anemia and chronic tiredness.

B-12 Extreme

Love this product. Gives me long-lasting energy.

Karen Z.

Helps for good health!!!

Product Lives Up To Its Name

My wife & I have been taking B12 Extreme for a number of years. We had been taking one tablet daily, sublingual as directed, but upon finding via lab tests our serum vitamin B levels were exponentially higher than normal we did cut back to twice weekly. Subsequent lab tests show B levels to now be only a bit above textbook normals. We do, though, add an extra one or two as needed for cold or other such symptoms.

Veronica V.
So far, so good

Great product. Easy to take. The only downside is how red it makes your entire mouth so take it when you can rinse after.


When I began using this my B12 levels were very low. Rather than use an injectable, which i have done, I decided to try something else. I found this product and gave it a try. I had blood work done 4 moths after taking it, my levels were very high! No big deal, your body eliminates the excess. The doc suggested I try taking it once a month instead of weekly. My levels a perfect now! Highly recommend!

Mark M.

Super supplement!

Frequently asked questions

It’s generally recommended to take vitamin B12 in the morning or afternoon because it can increase energy levels.
It can be beneficial to take several forms of vitamin B12 together. The two biologically active forms of vitamin B12 are methylcobalamin and dibencozide, but the other forms (hydroxo- and cyano-cobalamin) are also beneficial for cellular health, liver support and blood cell formation.
Vitamin B12 seems to be absorbed better on an empty stomach.
Store vitamin B12 lozenges in a cool, dry place and follow the expiration date listed on the package.