Healthy Diet and Lifestyle Slow Memory Loss, Even In APOE4 Carriers

• A 10-year study with over 29,000 people found that those with a healthy lifestyle (following 4 out of the 6 following factors: healthy diet, regular exercise, active social contact, active cognitive activity, never smoking, and never drinking) had slower memory decline. 

• This was even true in people with the APOE4 gene, which is associated with an increased risk of cognitive disorders. 

This article was posted on EurekAlert.org: [may be modified for content and length]

A healthy lifestyle, in particular a healthy diet, is associated with slower memory decline, finds a decade-long study of older adults in China, published today in The BMJ.

Even for carriers of the apolipoprotein E (APOE) gene - the strongest known risk factor for [neurological conditions and memory loss]- a healthy lifestyle was found to slow memory loss.

Memory continuously declines as people age, but evidence from existing studies is insufficient to assess the effect of a healthy lifestyle on memory in later life. And given the many possible causes of memory decline, a combination of healthy behaviours might be needed for an optimal effect.

To explore this further, researchers analysed data from 29,000 adults aged at least 60 years (average age 72; 49% women) with normal cognitive function who were part of the China Cognition and Aging Study.

At the start of the study in 2009, memory function was measured using the Auditory Verbal Learning test (AVLT) and participants were tested for the APOE gene (20% were found to be carriers). Follow-up assessments were then conducted over the next 10 years in 2012, 2014, 2016, and 2019.

A healthy lifestyle score combining six factors was then calculated: healthy diet, regular exercise, active social contact (eg. seeing friends and family), cognitive activity (eg. writing, reading, playing mahjong), non-smoking, and never drinking alcohol. 

Based on their score, ranging from 0 to 6, participants were put into favourable (4 to 6 healthy factors), average (2 to 3 healthy factors), or unfavourable (0 to 1 healthy factors) lifestyle groups and into APOE carrier and non-carrier groups.

After accounting for a range of other health, economic and social factors, the researchers found that each individual healthy behaviour was associated with a slower than average decline in memory over 10 years.

A healthy diet had the strongest effect on slowing memory decline, followed by cognitive activity and then physical exercise.

Compared with the group that had unfavourable lifestyles, memory decline in the favourable lifestyle group was 0.28 points slower over 10 years based on a standardised score (z score) of the AVLT, and memory decline in the average lifestyle group was 0.16 points slower.

Participants with the APOE gene with favourable and average lifestyles also experienced a slower rate of memory decline than those with an unfavourable lifestyle (0.027 and 0.014 points per year slower, respectively).

What’s more, those with favourable or average lifestyles were almost 90% and almost 30% less likely to develop [memory loss] or mild cognitive impairment relative to those with an unfavourable lifestyle, and the APOE group had similar results. 

This is an observational study so can’t establish cause and the researchers acknowledge some limitations, such as the potential for measurement errors due to self-reporting of lifestyle factors, and the possibility of selection bias, as some participants did not return for follow-up evaluations.

But this was a large study with a long follow-up period, allowing for evaluation of individual lifestyle factors on memory function over time. And findings remained significant after further analyses, suggesting that they are robust.

As such, the researchers say their results provide strong evidence that adherence to a healthy lifestyle with a combination of positive behaviours is associated with a slower rate of memory decline, even for people who are genetically susceptible to memory decline. 

They suggest further research could focus on the effects of a healthy lifestyle on memory decline across the lifespan, acknowledging that memory problems can also affect younger people, not included in this study. “These results might offer important information for public health initiatives to protect older adults against memory decline,” they conclude.

However, they point out that these results do not help to determine which among the six health behaviours included in the score (or specific combination) is the best target for [cognitive loss] prevention, or when in the life course to focus prevention efforts. Further insight is also needed to determine whether the differences in memory decline observed in this study are clinically meaningful, they add.

They suggest a similar approach that led to a substantial reduction in cardiovascular [conditions] should be taken with prevention [of cognitive loss], “identifying not only the factors that matter most but also the threshold at which they matter, and the age when intervention is likely to be most effective.”