A study in mice found that high sodium diets led to impaired cognitive function by depleting nitric oxide. Low nitric oxide levels can cause changes to the protein tau, which contributes to dementia.

The protein PERMIT plays a role in recycling dysfunctional mitochondria, which can lead to aging-related diseases. Aging mitochondria become leaky, which leads to reactive oxygen species.

Muscle weakness and impaired muscle performance was doubled among older adults with vitamin D deficiency. Older adults who exercised had lower likelihood of poor muscle strength and physical performance.

Mice were more motivated to exercise when they had two meals per day, similar to intermittent fasting. Ghrelin is an appetite-promoting hormone that increases during hunger and prompted the mice to exercise.