Blue light exposure from artificial lighting and electronics can accelerate aging, even it doesn't shine directly in the eyes. A study in fruit flies found that blue light exposure accelerated aging and impaired locomotion.

A protein called S100A9 acts as a blood sugar and lipid regulator under certain conditions, which may replicate the effects of insulin without harmful side effects as a potential diabetes treatment.

Excessive activity in the brain is correlated with a shorter lifespan, while suppressing the excessive activity extended life. This study shows that nervous system activity can play a role in longevity.

A cohort study found that people who became overweight before age 40 had significantly greater risk of developing cancer. The risks were highest for endometrial, male colon and male renal cell cancer.