Longevity Articles

Feeling Achy? Support Muscle, Tissue, and Joint Health With Muscle Relief Pro

Feeling Achy? Support Muscle, Tissue, and Joint Health With Muscle Relief Pro

What do people who live with muscular discomfort want most? Freedom.

Many people experience all-over aching and stiffness on waking in the morning, which may continue throughout the day with a variety of uncomfortable stabbing, burning, or throbbing sensations. They may think they will get relief at night, but unfortunately, the pain may intensify, preventing them from getting a good night’s sleep. 

A unique and novel all-in-one solution may be Muscle Relief Pro, a 10-ingredient formulation designed to provide complete muscle, tissue, and joint support and promote a healthier inflammatory response. Let’s take a closer look at the ten nutrients and compounds that will have you breathing a sigh of relief.

1.  Vitamin D3 

When the liver and kidneys break down vitamin D, it functions as a hormone and works throughout the body, affecting muscles, tissues, nerves, joints, and even the brain. In recent years, scientists have begun to recognize the link between low vitamin D levels and increased symptoms of pain.

A recent study from 2021 found that people with musculoskeletal pain who supplemented with vitamin D and participated in physiotherapy sessions experienced more significant reductions in pain-related outcomes than those who did physiotherapy alone. 

Another study from 2009 found that 75% of people attending a musculoskeletal clinic and experiencing pain were deficient in vitamin D. Following vitamin D supplementation, clinical improvements were observed in 90% of the patients. 

Vitamin D likely produces these beneficial effects due to its ability to promote a healthier inflammatory response in the body, including reducing the release of pro-inflammatory compounds called cytokines.

vitamin d supports muscle and joint health

2.  5-HTP

The amino acid 5-Hydroxytryptophan (5-HTP) is used by the body to increase the production of serotonin, a neurotransmitter involved in regulating sleep cycles, pain perception, mood, and the immune response. Some researchers think that disorders that cause muscular pain are rooted, in part, in serotonin dysregulation. These low serotonin levels can cause fatigue, sleeplessness, and musculoskeletal discomfort, among other things. 

Providing your body with healthy levels of serotonin through 5-HTP is thought to support a good night’s sleep, healthier moods, and looser muscles and joints in the morning. 

3 & 4.  Magnesium Hydroxide and Malic Acid

Magnesium is one of the most important nutrients required by our bodies. Yet, researchers estimate that 75-85% of American adults consume less than the recommended daily amount of magnesium, and up to half of Americans may have deficient or inadequate blood levels of the essential mineral.

Researchers have found that people with musculoskeletal pain are commonly deficient in magnesium. Magnesium has several functions, including the following:

  • Magnesium is involved in the production of serotonin. This may be another reason why people with musculoskeletal pain experience sleep disturbances and mood alterations. 
  • A magnesium deficiency can cause an increase of substance P Substance P is a neurotransmitter that serves as a pain messenger. People with musculoskeletal pain usually have exceptionally high levels of substance P, contributing to their hypersensitivity to pain.
  • Magnesium activates adenosine triphosphate (ATP). Energy is supplied to our bodies by our cells’ energy powerhouses, the mitochondria, in the form of ATP.  Researchers have found evidence of mitochondrial dysfunction in people with musculoskeletal pain, resulting in severe fatigue.

People with musculoskeletal pain tend to have decreased oxygen levels in their muscles, also known as muscle hypoxia. Biopsies of those muscles have shown muscle tissue breakdown, mitochondrial damage, and low levels of ATP, which helps explain the symptoms of widespread muscle pain. 

Malic Acid. A naturally occurring chemical found in foods like apples and pears, malic acid may help ease discomfort related to muscle and tissue hypoxia. As malic acid is used and synthesized in the mitochondria as part of the Krebs’ cycle, it allows the body to make ATP — and thereby, energy — more efficiently, even under low oxygen or hypoxic conditions.

Magnesium plus Malic Acid. While magnesium alone is often not sufficient to provide relief, combining these two compounds may help support muscle and joint health. One study looked at people with musculoskeletal pain who supplemented with a dose of 300-600 mg of magnesium and 1,200-2,400 mg of malic acid for four to eight weeks. Although the study only included 15 people, every single patient experienced significant improvements in pain-related symptoms — some in as little as 48 hours. 

5 & 6.  Glucosamine Sulfate and Chondroitin Sulfate

Glucosamine sulfate is a naturally occurring chemical found in cartilage cells and the fluid surrounding your joints. The body uses it to produce various other substances involved in building tendons, ligaments, cartilage, and the thick fluid that surrounds joints. Researchers think that taking glucosamine sulfate supplements may support healthier cartilage and the fluid surrounding joints or help prevent the breakdown of these substances — or perhaps both.

Chondroitin is an amino acid found inside your joint cartilage that keeps your joints lubricated by attracting and absorbing water. Supplementing with chondroitin can help support joint mobility and range of motion and promote a healthier inflammatory response, which is tightly linked to joint comfort. 

7.  MSM

Methyl-sulfonyl-methane (MSM) is an organic sulfur-containing compound and is a crucial component of the body’s connective tissues. Among its many benefits, MSM has been found to exhibit antioxidant properties, and it promotes a healthy inflammatory response in joint tissue that can result in more joint flexibility.

8. Boswellin®

Boswellin (Boswellia serrata), also known as Indian frankincense, has been used in Ayurvedic healing practices for hundreds of years to support a healthier inflammatory response. The active ingredient of Boswellin, oleoresin, consists of essential oils, gums, and compounds called terpenoids. The terpenoid portion contains boswellic acids, which are responsible for inhibiting pro-inflammatory enzymes and cytokines. 

One recent study pooled data from seven trials, including 545 people with knee pain. They found that those supplemented with Boswellia serrata experienced significant reductions in symptoms of pain and stiffness, with improvements in joint function and mobility. 

supplements to support muscle and joint health

9.  Curcumin

Curcumin is the primary component of turmeric (Curcuma longa L.) and is what gives the spice its rich yellow color. Turmeric is the star ingredient in curry and is widely used in Indian cuisine. In addition to its uses as a flavor enhancer, turmeric has been employed in Ayurvedic healing for more than 4,000 years. 

Researchers widely recognize curcumin as a powerful supporter of the body’s natural mechanisms for modulating the inflammatory response. Based on the studies done thus far, curcumin shows excellent promise as an option for promoting healthier inflammatory pathways.

A recent study looked at the effects of combining supplemental curcumin and Boswellia. Compared to a common prescription drug for pain, the curcumin-Boswellia combination significantly improved scores on physical performance tests and reduced morning stiffness and painful joints. 

10.  White Willow Bark

The bark of the white willow tree contains salicin, which converts to salicylic acid in your body. Salicin is a chemical similar to aspirin (acetylsalicylic acid). It is thought to be responsible for white willow bark’s ability to support the natural reduction of muscle discomfort and a healthier inflammatory response. 

In fact, the ancient physicians Hippocrates and Galen were the first to describe these effects, advising patients to chew on white willow bark as a remedy for pain, fevers, and inflammation. Although white willow bark appears to promote benefits more slowly than aspirin, they may last longer.

Key Takeaway:

Muscle Relief Pro contains a unique combination of ten natural nutrients and compounds known for their ability to support muscle, tissue, and joint health, promote increased serotonin production, and encourage a healthier inflammatory response. Talk to your healthcare provider about potential nutrient-drug interactions before taking this supplement or any other. 

Updated by Cambria Glosz, MS, RD in January 2022


Ali M, Uddin Z, Hossain A. Combined Effect of Vitamin D Supplementation and Physiotherapy on Reducing Pain Among Adult Patients With Musculoskeletal Disorders: A Quasi-Experimental Clinical Trial. Front Nutr. 2021;8:717473. Published 2021 Oct 5. doi:10.3389/fnut.2021.717473

Badsha H, Daher M, Ooi Kong K. Myalgias or non-specific muscle pain in Arab or Indo-Pakistani patients may indicate vitamin D deficiency. Clin Rheumatol. 2009;28(8):971-973. doi:10.1007/s10067-009-1146-7

DiNicolantonio JJ, O'Keefe JH, Wilson W. Subclinical magnesium deficiency: a public health crisis. Open Heart. 2018;5(1):e000668. Published 2018 Jan 13. doi:10.1136/openhrt-2017-000668

Haroyan A, Mukuchyan V, Mkrtchyan N, et al. Efficacy and safety of curcumin and its combination with boswellic acid: a comparative, randomized, double-blind, placebo-controlled study. BMC Complement Altern Med. 2018;18(1):7. Published 2018 Jan 9. doi:10.1186/s12906-017-2062-z

Russell IJ, Michalek JE, Flechas JD, Abraham GE. Treatment with Super Malic: a randomized, double-blind, placebo-controlled, crossover pilot study. J Rheumatol. 1995;22(5):953-958.

Yu G, Xiang W, Zhang T, Zeng L, Yang K, Li J. Effectiveness of Boswellia and Boswellia extract: a systematic review and meta-analysis. BMC Complement Med Ther. 2020;20(1):225. Published 2020 Jul 17. doi:10.1186/s12906-020-02985-6

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