5 Questions Answered About NMN Pro Complete

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5 Questions Answered About NMN Pro Complete

If you search for supplements that support healthy aging, you’re bound to find a seemingly endless list. So, how in the world is anyone supposed to choose from this sea of supplements? 

A good place to start is with supplements that work through NAD+ metabolism. NAD+ is a vital molecule found in every living animal cell and is a fundamental molecule in human life and health. This tiny molecule plays an essential role in energy metabolism and cell function, survival, and death.

A lot of these fundamental cellular functions work through a family of enzymes called sirtuins, which depend on NAD+ to function. Sirtuin activation is intimately linked to DNA integrity, healthy metabolism, and the function, health, and aging of many organ systems, such as the immune, cardiovascular, and nervous systems.

But there’s some evidence that, with age, NAD+ levels begin to drop, and, with this, so does sirtuin function. This causes a domino effect of problems, starting with the accumulation of DNA damage, which causes oxidative stress that ultimately interferes with cell function.

For these reasons, replenishment through NAD+ precursors has great potential as a target for healthy aging.

So, what’s the best way to harness NAD+ biology to support healthy aging? Well, we think the answer lies in NMN Pro Complete.

What is in NMN Pro Complete?

This formula contains a mix of compounds that all have been shown to support health and aging. NMN Pro Complete is an optimized formulation of:

  • Nicotinamide mononucleotide (NMN): a direct precursor to NAD+ that serves to replenish and boost levels of this vital compound. In a recent clinical study, after a single oral administration of 100-500 mg of NMN in 10 healthy men, the plasma concentrations of NMN and NAD+ metabolites increased significantly (Irie et al., 2020).
  • Trans-resveratrol: a plant-based product that acts as a sirtuin activator. A natural phytoalexin — a substance that is produced by plant tissues in response to contact with a parasite and specifically inhibits the growth of that parasite — produced by various plants like the red grapes, peanuts, and berries.
  • Trimethylglycine (TMG): a methyl donor that complements NMN supplementation by helping replenish the body's methyl pool. As NAD+ does its work, it is broken down to nicotinamide, which is mostly converted to methylnicotinamide. The methyl group for this bioconversion must come from a methyl donor; however, if the methyl group comes from the methyl pool in your body, then it puts stress on that pool, which has its hands in many processes relating to cardiovascular, neurological, reproductive, liver, and metabolic health.
What is in NMN Pro Complete?

    What research is there on the components in NMN Pro Complete?

    Preclinical studies using NMN have shown broad health benefits, including supporting vascular and metabolic health. There is also evidence for NMN in supporting mitochondrial health, which is central to the healthy function and aging of many organ systems, including the cardiovascular/circulatory and nervous systems. A very recent clinical study showed that NMN increased muscle blood sugar sensitivity in prediabetic women (Yoshino et al., 2021).

    The beneficial properties of trans-resveratrol are extensively depicted in the literature and include serving as an anti-oxidant. Clinical research has shown that regular consumption of resveratrol can support healthy cognition and cerebrovascular functions (Garrigue et al., 2021), blood-sugar metabolism (Rabbani et al., 2021), and gut immune responses (Samsami-Kor et al., 2015).

    TMG – also called betaine anhydrous, or betaine for shot – helps the body metabolize an amino acid called homocysteine. Higher levels of homocysteine are associated with problems with cardiovascular health. Studies in rats suggest that TMG may help protect against harmful fatty deposits in the liver.

    Why is NMN Pro Complete micronized?

    Not only does is this formulation a perfect balance of ingredients, but it is also prepared in a manner to maximize the absorption and bioavailability of these components. The NMN Pro Complete formulation is micronized, meaning that the particle sizes are measured in microns – or a millionth of a meter (1/1,000,000 meters). Reducing the particle size by micronization is a direct way to increase a compound’s solubility and its permeability through the body’s membranes. The more soluble and small a drug is, the more likely it will be absorbed and used by cells.

    How do I know the quality of my NMN Pro Complete?

    Each batch of NMN Pro Complete undergoes laboratory inspection by a professional analytical laboratory service that performs chemical and microbiological testing on nutraceuticals and dietary supplements following current Good Manufacturing Practice (cGMP) regulation and NSF, FDA, and ISO guidelines and standards. You will receive a Certificate of Analysis with each order placed.

    How much NMN Pro Complete should I take?

    Instead of having to take three separate supplements each day, you can now get the ideal balance of all three in one convenient serving. A single scoop of NMN Pro Complete will provide you with 1,000 mg of NMN, 1,000 mg of trans-resveratrol, and 500 mg of TMG – a dosage compiled from recommendations of the world's leading longevity experts. NMN Pro Complete can currently be purchased in two sizes: 37.5 g (15 servings) or 75 g (30 servings). NMN Pro Complete is recommended to be mixed with water for consumption.

    What is in NMN Pro Complete?

    The take home message on NMN Pro Complete

    All in all, what makes the NMN in NMN Pro Complete so special, is that you can be assured you’re getting a product you can trust to be of exceptionally high quality, purity, and potency.

    Show references

    Garrigue P, Mounien L, Champion S, Mouhajir Y, Pechere L, Guillet B, Landrier JF, Seree E. Long-term administration of resveratrol at low doses improves neurocognitive performance as well as cerebral blood flow and modulates the inflammatory pathways in the brain. J Nutr Biochem. 2021 Nov;97:108786. doi: 10.1016/j.jnutbio.2021.108786. Epub 2021 Jun 1. PMID: 34082127.

    Irie J, Inagaki E, Fujita M, Nakaya H, Mitsuishi M, Yamaguchi S, Yamashita K, Shigaki S, Ono T, Yukioka H, Okano H, Nabeshima YI, Imai SI, Yasui M, Tsubota K, Itoh H. Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men. Endocr J. 2020 Feb 28;67(2):153-160. doi: 10.1507/endocrj.EJ19-0313. Epub 2019 Nov 2. PMID: 31685720.

    Rabbani N, Xue M, Weickert MO, Thornalley PJ. Nutrients. 2021 Jul 11;13(7):2374. doi: 10.3390/nu13072374. PMID: 34371884; PMCID: PMC8308792.

    Samsami-Kor M, Daryani NE, Asl PR, Hekmatdoost A. Arch Med Res. 2015 May;46(4):280-5. doi: 10.1016/j.arcmed.2015.05.005. Epub 2015 May 20. PMID: 26002728.

    Yoshino M, Yoshino J, Kayser BD, Patti GJ, Franczyk MP, Mills KF, Sindelar M, Pietka T, Patterson BW, Imai SI, Klein S. Nicotinamide mononucleotide increases muscle sensitivity in prediabetic women. Science. 2021 Jun 11;372(6547):1224-1229. doi: 10.1126/science.abe9985. Epub 2021 Apr 22. PMID: 33888596; PMCID: PMC8550608.

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