Cannot feel anything working. However, this is one supplement that science shows should work. So I'm not expecting to "feel" anything per se. The only tangible thing I notice is that I do not look like I'm 62 years of age. I have no age spots anywhere on my body, including my hands. And my hands also look like a much younger person, even younger than my spouse who is 13 years younger than me. The skin is plump and full, not "bony" like most older folks. Additionally, I have absolutely no wrinkles at all and a full head of hair. Plus, I am very athletic as well. I take Fisetin as an insurance policy.