ProHealth Longevity

Calcium AKG Longevity (1,000 mg per 2 capsule serving, 60 capsules) by ProHealth Longevity

SKU: PH591



Support Energy Production, Bone Strength, and Metabolic Function With Age

  • Supports healthy aging processes
  • Supports heart, bone, and metabolic health
  • Supports cognitive vitality
  • Helps to boost antioxidant levels inside cells

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Supplement Facts
Supplement Facts
Serving Size: 2 Capsules
Servings Per Container: 30
Amount Per Serving %DV
Calcium Alpha Ketoglutarate 1,000 mg
† Daily Value not established

  • Other Ingredients: Organic Rice Flour, Vegetarian Capsule (Cellulose and water)
  • Does Not Contain: Artificial colors, flavors, preservatives, dairy, eggs, fish, shellfish, tree nuts, peanuts, wheat, gluten, soybean, corn, or yeast.
  • Suggested Daily Use: Take 2 capsules daily, in the morning, with or without food.
  • Storage: Store in a cool, dry place away from direct light. 
  • Caution: If you are pregnant, nursing, have a medical condition or are taking prescription drugs, consult your health care professional before using this product. KEEP OUT OF REACH OF CHILDREN.

Alpha-ketoglutarate (AKG) is a compound that is created naturally in the body but tends to diminish with age. In supplement form, AKG can be attached to a calcium salt (Ca-AKG), which has been studied for its role in supporting metabolic function and longevity (1).

Ca-AKG is involved in stimulating protein synthesis and energy production in the body, as it is a vital component of the Krebs cycle - the process that creates ATP (energy) from food. Ca-AKG is also a source of the essential amino acids needed to make collagen, which is a protein that helps to support bone and muscle health.

Additionally, Ca-AKG facilitates our internal recycling process known as autophagy, which removes dysfunctional cells, cell parts, and proteins from the body. Autophagy tends to decrease with age, so Ca-AKG may be able to help support this process.

Research has found that AKG lengthened lifespan in roundworms by up to 50% and delayed signs of aging (2). This may be because Ca-AKG activates AMP-activated protein kinase (AMPK) - a pathway that senses and maintains cellular energy balance by supporting the function of our cells’ main energy hubs (the mitochondria) and healthy blood sugar control (3).

Ca-AKG has also been shown to boost cellular antioxidant levels in aged mice, which helped support the mice’s blood vessel elasticity - a measure of good cardiovascular health (4).


  1. Asadi Shahmirzadi A, Edgar D, Liao CY, et al. Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice. Cell Metab. 2020;32(3):447-456.e6. doi:10.1016/j.cmet.2020.08.004

  2. Chin R, Fu X, Pai M., et al. The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR. Nature. 2014;510:397–40.

  3. Wu N, Yang M, Gaur U, Xu H, Yao Y, Li D. Alpha-Ketoglutarate: Physiological Functions and Applications. Biomol Ther (Seoul). 2016;24(1):1-8. doi:10.4062/biomolther.2015.078

  4. Niemiec T, Sikorska J, Harrison A, et al. Alpha-ketoglutarate stabilizes redox homeostasis and improves arterial elasticity in aged mice. J Physiol Pharmacol. 2011;62(1):37-43.

Customer Reviews

Based on 24 reviews
Stevo L.
Stevo L.

Great product!

Marc B.
excellent anti-aging supplement

excellent quality Brand...price are affordable...thanks


wish they had a large bottle so i didnt get like a million little bottles otherwise it works fine :)

Emile B.
Great Product

I have been taking "Calcium AKG Longevity" for a month now and I'm finally starting to feel the difference. At 71 it's the boost I needed.

John M.

Calcium AKG Longevity (1,000 mg per 2 capsule serving, 60 capsules) by ProHealth Longevity

Harriet M.
More energy

I take AKG every morning and have increased productivity and more energy.

Wilson C.
Good Product

I have taken it for few weeks so far do not have any adverse effect.

Debbie R.
Reverse graying hair

This is an awesome product. It has slowed and reversed my graying hair. I am 52 and would usually color my edges every 3 weeks but since using this product (1x every other day) for the last month, I've noticed way less gray coming in and have decided to stop dying my edges. Good quality product!

Calcium AKG Longevity Review


Sadoon A.S.
Good supplement

I feel fine after I take it usually within 2 hours, no major changes in my general health, but I still feel better overall, I've been taking this supplement for over three months now .