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NMN Pro™ 500 - Uthever® NMN - 500 mg per serving, 30 servings - 3 Pack

SKU: PH583C

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Helps combat aging, improves heart health and promotes muscle strength

  • NMN supplementation has been found to improve various parameters of health, including physical endurance and muscle strength, neurological function, heart health, body weight and gene expression.
  • Nicotinamide mononucleotide (NMN) is a derivative of the B-vitamin niacin that dramatically improves health and longevity by serving as a precursor to NAD+.

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Supports Longevity. Studies have shown that boosting NAD+ synthesis in the body extends the lifespan of yeast, worms and flies. (1)

Blood Sugar Regulation. As we age, we have more trouble processing glucose, leading to higher blood sugar. Supplemental NMN is shown to improve several markers of skeletal muscle glucose metabolism that are commonly dysregulated in people with metabolic disorders. (2)

Supports Metabolism and Healthy Weight. Although excessive body weight can develop at any age, adults over age 40 are particularly susceptible to age-related weight gain as metabolism slows down and body composition is altered to favor fat over lean muscle. As obese individuals have reductions in both NAD+ levels and ATP (energy) production, replenishing NAD+ through NMN can help to reverse this while improving metabolic pathways to maintain a healthy weight. (3,4,5)

Supports Healthy Cognition: Declining cognitive function with age is related to a reduced NAD+ levels that impair mitochondrial function. Replenishing NAD+ stores through NMN may be able to prevent this dysfunction. (6,7)

Supports Healthy Skin: In our 30s and 40s, the appearance of our skin can start to show signs of age. Several studies have examined how boosting NAD+ levels in the skin prevents premature skin aging or supports a healthier external appearance. (8,9)

References:

1. Fang EF, Kassahun H, Croteau DL, et al. NAD+ Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair. Cell Metab. 2016;24(4):566-581. doi:10.1016/j.cmet.2016.09.004

2. Feng Z, Qin Y, Huo F, et al. NMN recruits GSH to enhance GPX4-mediated ferroptosis defense in UV irradiation induced skin injury. Biochim Biophys Acta Mol Basis Dis. 2022;1868(1):166287. doi:10.1016/j.bbadis.2021.166287

3. Gopi S, Balakrishnan P. Evaluation and clinical comparison studies on liposomal and non-liposomal ascorbic acid (vitamin C) and their enhanced bioavailability. J Liposome Res. 2021;31(4):356-364. doi:10.1080/08982104.2020.1820521

4. Katayoshi T, Nakajo T, Tsuji-Naito K. Restoring NAD+ by NAMPT is essential for the SIRT1/p53-mediated survival of UVA- and UVB-irradiated epidermal keratinocytes. J Photochem Photobiol B. 2021;221:112238. doi:10.1016/j.jphotobiol.2021.112238

5. Kim M, Seol J, Sato T, Fukamizu Y, Sakurai T, Okura T. Effect of 12-Week Intake of Nicotinamide Mononucleotide on Sleep Quality, Fatigue, and Physical Performance in Older Japanese Adults: A Randomized, Double-Blind Placebo-Controlled Study. Nutrients. 2022;14(4):755. Published 2022 Feb 11. doi:10.3390/nu14040755

6. Kiss T, Nyúl-Tóth Á, Balasubramanian P, et al. Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects. Geroscience. 2020;42(2):527-546. doi:10.1007/s11357-020-00165-5

7. Liao B, Zhao Y, Wang D, Zhang X, Hao X, Hu M. Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study. J Int Soc Sports Nutr. 2021;18(1):54. Published 2021 Jul 8. doi:10.1186/s12970-021-00442-

8. Mills KF, Yoshida S, Stein LR, et al. Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice. Cell Metab. 2016;24(6):795-806. doi:10.1016/j.cmet.2016.09.013

9. Tarantini S, Valcarcel-Ares MN, Toth P, et al. Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice. Redox Biol. 2019;24:101192. doi:10.1016/j.redox.2019.101192

10. Wang X, Hu X, Yang Y, Takata T, Sakurai T. Nicotinamide mononucleotide protects against β-amyloid oligomer-induced cognitive impairment and neuronal death. Brain Res. 2016;1643:1-9. doi:10.1016/j.brainres.2016.04.060

11. Yoshino J, Mills KF, Yoon MJ, Imai S. Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Cell Metab. 2011;14(4):528-536. doi:10.1016/j.cmet.2011.08.014

12. Yoshino M, Yoshino J, Kayser BD, et al. Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science. 2021;372(6547):1224-1229. doi:10.1126/science.abe9985

Supplement Facts
Serving Size: 1 Capsule
Servings Per Container: 30
Amount Per Serving %DV
Uthever™ β-Nicotinamide Mononucleotide (NMN)
500 mg
† Daily Value not established.
REV. 11.23
  • OTHER INGREDIENTS: Vegetable capsule, rice flour.
  • DOES NOT CONTAIN: Dairy, egg, soy, wheat, gluten, corn, fish, shellfish, tree nuts, peanuts.
  • SUGGESTED DAILY USE: Take 1-2 capsules, with or without food, preferably in the morning, or as recommended by your healthcare professional.
  • NOTE: Store in a cool, dry place, away from direct sunlight. Do not use if tamper-evident packaging is broken. KEEP OUT OF REACH OF CHILDREN.
  • CAUTION: Not intended for use if you are pregnant or nursing. Not formulated for use in children. If you have a medical condition or are taking medications, consult with your healthcare professional before using this product.
  • Only Clincially-Proven NMN. ProHealth’s NMN is the only clinically-proven NMN to boost NAD+ levels in a peer-reviewed, double-blind, placebo-controlled, published, clinical study. Results of the study indicated a 38% increase in NAD+ levels and 12-year reversal in biological age.
  • Unique Delivery Method. NMN Pro 500 focuses on delivery into the small intestine’s Slc12a8 transporter sites, where absorption is maximized and is increased over 100 times, greatly enhancing bioavailability.
  • Solvent-Free. Compared to other NMN products, ours is made without any chemical solvents.
  • Quality Manufacturing Practices. All of our products are manufactured in an FDA-registered, GMP-certified facility.
  • Third-Party Tested in the USA. Every batch is third-party tested in US laboratories to ensure the highest quality, purity and potency. Certificates of Analysis are available.
Be Aware of Fake NMN: Fraudulent companies are always attempting to out-price competitors by using NMN fake ingredients to gain market share, which is not fair to you, the consumer, or the reputable companies, like ProHealth that spends time and resources to ensure a safe and pure NMN product.
  • Nicotinamide mononucleotide (NMN) is a derivative of the B-vitamin niacin that dramatically improves health and longevity by serving as a precursor to NAD+.
  • NMN supplementation has been found to improve various parameters of health, including physical endurance and muscle strength, neurological function, heart health, body weight and gene expression.
  • NMN Pro 500 capsules provide maximum absorption by focusing delivery into the small intestine's Slc12a8 NMN transporter sites, where NMN absorption is increased over 100 times.

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I love this supplement!

I love this supplement!

"Definitely can tell a difference in my overall sense of well being and energy level. I’ve been taking this for about a month and plan to make this supplement one that I will stay on."

Tammy B. - Verified ProHealth Longevity Customer

Customer Reviews

Based on 1495 reviews
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A
Anonymous
Best run time in years!

I love traing and running is my go to work out. Within just a weeks of starting my NMN Pro Health supplement program, I noticed improved runtimes that I had ent seen in years!

I
Ida R.

Amazing product! Already feeling the difference.

E
Eli

NMN Pro 1000™ - Uthever® NMN, 1000 mg per serving, 60 capsules - 3 Pack

J
Joel P.
So far, so good!

Very satisfied with the product!

L
Leo
Great product

So far so good

B
Brandon M.
Great product

Exactly what was ordered.

P
Paul P.
Review

Best product on the market

M
Murray W.
Pro Health Is Legit

I have been a customer for years now. They are top tier across the board. I switched to capsules for precise control of dosage. All is well.

J
James S.
NMN - best quality

This is the best NMN out there

B
Bruce T.
Great Product

I have been using NMN Pro 1000 and are thrilled with the results

Frequently asked questions

NMN performs most of its functions on a cellular level and results are not always outwardly apparent. However, many individuals taking NMN report feeling increased energy levels, improved cognitive health, and enhanced exercise performance.
While results may vary based on a variety of factors, NMN has been shown to significantly increase NAD+ levels in humans in as little as 30 days.
Most experts in the longevity field take 1000mg of NMN daily.
Some research shows that NMN may extend lifespan due to its ability to increase NAD+ levels in the body. Research shows that increasing NAD+ levels in aged animals extends their lifespan.
Clinical research conducted on humans taking NMN shows no clinically relevant adverse effects.