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ESSENTIALS
Science-Driven NMNH Without the Premium Price.
Rigorously manufactured NMNH designed to support youthful NAD+ levels — at a price point built for consistency.
✔ High-Purity NMNH
✔ Fast-dissolving Formulation
✔ Designed for Daily Use
✔ Accessible Pricing
NMNH (dihydronicotinamide mononucleotide) is the reduced form of NMN, differing by a single added hydrogen atom on the nicotinamide ring.
This structural change alters how the molecule interacts with NAD+ biosynthesis enzymes, allowing it to bypass key rate-limiting steps (NAMPT and NRK). As a result, NMNH is considered a potentially faster-acting and more potent NAD+ precursor.
Advanced Amorphous Formulation:
Our formulas are doctor-formulated using research-supported ingredients and clinically relevant dosages.
Supports Healthy NAD+ Levels:
Formulated to support bioavailability to help your body absorb and use NMNH efficiently for everyday cellular energy support.*
Lab-Grade Science, Everyday Pricing:
Delivers the same NMNH molecule trusted in university longevity research — without the premium clinical trial markup.*
Pure NMNH:
Clinically studied dosing to support rapid NAD+ restoration and cellular energy.*
Rich Carson
Founder of ProHealth
"Our new Essentials line is all about quality, selection, and price. Longevity supplements can be expensive, often putting them beyond reach for many who value their health. We created Nexergy+™ NMNH to make premium-quality longevity support accessible to more people — while upholding the exceptional purity and trust that define every ProHealth product."
What is NMNH?
- NMNH (dihydronicotinamide mononucleotide) is the reduced form of NMN, differing by a single added hydrogen atom on the nicotinamide ring.
- This structural change alters how the molecule interacts with NAD+ biosynthesis enzymes, allowing it to bypass key rate-limiting steps (NAMPT and NRK). As a result, NMNH is considered a potentially faster-acting and more potent NAD+ precursor.
How is NMNH different from NMN?
What are the potential benefits of NMNH?
- NMNH may increase intracellular NAD+ levels more than NMN at equivalent doses (up to 4–10× in some models).
- Faster onset (15–30 minutes in animal studies) and longer duration (up to 24 hours).
May support:
- Energy metabolism
- DNA repair
- Cellular health and aging pathways
- Demonstrated protective effects against oxidative stress in cell studies.
What is the typical dosage for NMNH?
Clinical research has studied:
- 125 mg, 250 mg, and 500 mg daily for 90 days
- All doses showed NAD+ increases with good tolerability
Always follow product label instructions and consult a professional for personalized guidance.
What is Nexergy+™ NMNH?
Nexergy+™ NMNH is an amorphous (non-crystalline) form of NMNH designed to enhance dissolution and absorption.
- Uses a disordered structure instead of a crystalline lattice
- Aims to improve solubility and bioavailability
- Designed for efficient, accessible NAD+ support
How is Nexergy+™ NMNH different from regular NMN?
- Like all NMNH, it carries the extra hydrogen that allows bypassing rate-limiting steps
- The amorphous structure may:
- Dissolve faster in the GI tract
- Potentially improve uptake compared to some crystalline forms
Is Nexergy+™ NMNH safe?
- Contains the same NMNH molecule studied in preclinical and human trials
- Only differs in physical structure (amorphous vs. crystalline)
As with all NAD+ precursors, consult a healthcare provider if pregnant, nursing, or taking medications.
Is there clinical research on Nexergy+™ NMNH?
Nexergy+™ is supported by:
- Broader NMNH research
- Pharmaceutical literature on amorphous delivery systems
However:
- No ingredient-specific human clinical trials for Nexergy+™ yet
- UthPeak® NMNH currently has the only published Phase I trial for a branded NMNH ingredient
What is the typical dosage for Nexergy+™ NMNH?
Generally aligns with NMNH research ranges:
- Low- to mid-hundreds of mg daily
Always follow label directions and consult a healthcare provider.
Can Nexergy+™ NMNH be combined with other NAD+ boosters?
Yes, but with consideration:
- Can be part of a broader longevity routine (exercise, sleep, metabolic health)
- When stacking NAD+ precursors:
- Total niacin-related intake can accumulate
- Best approached cautiously
Professional guidance is recommended for optimal dosing and combinations.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease
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2 Yang Y et al. J Biol Chem. 2019;294(23):9295-9307.
3 Trammell SA et al. Nat Commun. 2016;7:12948.
4 Palmer RD et al. Aging Med Milton NSW. 2021;4(3):214-220.
5 Yang Y et al. Nat Metab. 2020;2(4):364-379.
6 Irie J et al. Endocr J. 2020;67(2):153-160.
7 Fukamizu Y et al. Sci Rep. 2022;12(1):14442.
8 Okabe K et al. Front Nutr. 2022;9:868640.
9 Zapata-Pérez R et al. FASEB J. 2021;35(4).
10 Henderson JD et al. NPJ Aging. 2024;10(1):7.
11 Conze D et al. Sci Rep. 2019;9(1):9772.
