Pterostilbene Pro 250 - 250 mg, 60 capsules

SKU: PH577

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96% would recommend this product (25 votes)

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Pterostilbene is a powerful antioxidant that is similar to, but more bioavailable than resveratrol. Pterostilbene promotes longevity and improves markers associated with heart and brain health.

  • Supports cardiovascular health* 
  • Promotes brain cell health* 
  • Activates sirtuins to support healthy aging 
  • Boosts effectiveness of NMN 

Research-Supported Benefits:

Supports Longevity. Pterostilbene activates “longevity genes” known as sirtuins. Research shows that activating sirtuins promotes cellular health and extends lifespan of animals. 1 2 Activating sirtuins aids in DNA repair, promoting cellular stress resistance, regulating autophagy (cellular detoxification) and inflammation. 3

Promotes Heart Health. Research shows that pterostilbene promotes heart health in a variety of ways, one of which is reducing oxidative stress of the heart. 4 Oxidative stress contributes to inflammation and accelerated aging of heart cells. Reducing levels of oxidative stress reduces risk of age-related decline of heart health.

Protects the Aging Brain. Pterostilbene has been shown to reduce neuroinflammation (inflammation of brain cells), reducing oxidative-stress-related damage to brain cells 5. Research shows that neuroinflammation contributes to age-related brain decline symptoms such related to memory and information processing.6


1. Cheng Y, Di S, Fan C, et al. SIRT1 activation by pterostilbene attenuates the skeletal muscle oxidative stress injury and mitochondrial dysfunction induced by ischemia reperfusion injury. Apoptosis. 2016;21(8):905-916. doi:10.1007/s10495-016-1258-x 

2. Lee SH, Lee JH, Lee HY, Min KJ. Sirtuin signaling in cellular senescence and aging. BMB Rep. 2019;52(1):24-34. doi:10.5483/BMBRep.2019.52.1.290 doi:10.5483/BMBRep.2019.52.1.290 

3. Vazquez BN, Thackray JK, Serrano L. Sirtuins and DNA damage repair: SIRT7 comes to play. Nucleus. 2017;8(2):107-115. doi:10.1080/19491034.2016.1264552

4. Kosuru R, Kandula V, Rai U, Prakash S, Xia Z, Singh S. Pterostilbene Decreases Cardiac Oxidative Stress and Inflammation via Activation of AMPK/Nrf2/HO-1 Pathway in Fructose-Fed Diabetic Rats. Cardiovasc Drugs Ther. 2018;32(2):147-163. doi:10.1007/s10557-018-6780-3

5. Park B, Lee YJ. Pterostilbene Improves Stress-Related Behaviors and Partially Reverses Underlying Neuroinflammatory and Hormonal Changes in Stress-Challenged Mice. J Med Food. 2021;24(3):299-309. doi:10.1089/jmf.2020.4766

6. Ahmad MA, Kareem O, Khushtar M, et al. Neuroinflammation: A Potential Risk for Dementia. Int J Mol Sci. 2022;23(2):616. Published 2022 Jan 6. doi:10.3390/ijms23020616

  • Pterostilbene has been shown to activate longevity genes known as sirtuins, which play a critical role in regulating cellular aging. 
  • Sirtuins require NAD+ for fuel, making pterostilbene and NMN a perfect supplement combination to promote longevity. 
  • By activating sirtuins, pterostilbene supports DNA stability and promotes DNA repair. 
  • Pterostilbene’s antioxidant effects promote heart and brain health by reducing oxidative stress and inflammation. 
Supplement Facts
Serving Size: 1 Capsule
Servings Per Container: 60
Amount Per Serving %DV
Pterostilbene (Trans-pterostilbene)
250 mg
† Daily Value not established.

  • OTHER INGREDIENTS: Vegetable capsule, rice our.
  • DOES NOT CONTAIN: Dairy, egg, soy, wheat, gluten, corn, fish, shellfish, tree nuts,
  • SUGGESTED DAILY USE: Take 1 capsule once or twice daily, with food, preferably in the morning, or as recommended by your healthcare professional.
  • CAUTION: Not intended for use by pregnant or nursing women. Not formulated for use in children. If you have a medical condition or are taking medications, consult with your healthcare professional before using this product.
  • NOTE: Store in a cool, dry place, away from direct sunlight. Do not use if tamper-evident packaging is broken. KEEP OUT OF REACH OF CHILDREN.

Clinical-Supported Dosing. ProHealth Longevity’s Pterostilbene Pro 250 contains 250 mg of pterostilbene per serving, a clinically effective dose to promote longevity.

Quality Manufacturing Practices. All of our products are manufactured in an FDA-registered, GMP-certified facility.

Third-Party Tested in the USA. Every batch is third-party tested in US laboratories to ensure the highest quality, purity and potency. Certificates of Analysis are available.

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Customer Reviews

Based on 49 reviews
Bruce B.
A Very Important Anti-Aging Supplement from Everything I Read

I simply feel a greater overall sense of well-being from taking a supplement that is highly touted in the anti-aging research community as important to overall health in the long run.

Regina N.

I’ve only used it for an about a month. But I’m curious to see what happens

Amy F.

Good for you, great supplement. Buy

B T.
Awesome product

I love this product. Super reputable company.

Good quality

Found the quality to be very good.

Craig B.
Great product

Easy to take and no side effects

Charles D.

Pterostilbene Pro 250 - 250 mg, 60 capsules

Nicolas O.

I’ve read Hyman book, Longevity Diet and he takes Pterostilbene. I’ve also check different studies comparing it with resveratrol, Pterostilbene is far superior!

Drew P.
Difficult to assess

It's impossible to say if this has been beneficial because the health benefits are not obvious. It's more about long term health. This company is solid and that's why I buy from them.


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Frequently asked questions

While pterostilbene and resveratrol have many similarities, pterostilbene has been shown to be significantly more bioavailable (better absorbed) than resveratrol.
While pterostilbene has a been shown to be both safe and effective, some research shows high dose pterostilbene supplementation may increase LDL cholesterol.
ProHealth’s Pterostilbene Pro 250 is formulated to be free of common allergens including dairy, egg, soy, fish, gluten, wheat and artificial preservatives.