Nicotinamide Riboside Pro 500 - 500 mg NIAGEN® + 250 mg TMG per serving, 60 capsules

SKU: PH628

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NAD+ precursor that supports cellular function, heart health and cognition

  • Nicotinamide riboside (NR) is a derivative of the B-vitamin niacin that supports health and longevity by serving as a precursor to NAD+.
  • NR supplementation has been found to improve various parameters of health, including cardiovascular health, cognition and neurological function, gene expression and healthy body weight.

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Supports Cognition. Declining cognitive function with age is related to reduced NAD+ levels that impair mitochondrial function. Replenishing NAD+ stores through NR may be able to prevent this dysfunction. One study found that adults with a newly diagnosed neurodegenerative condition who took 1,000 mg NR for 30 days had increased cerebral NAD+ levels, mild clinical improvement and reduced activity of pro-inflammatory molecules in the cerebrospinal fluid. NR also increased the activity of genes involved with mitochondrial function and antioxidant responses. In animal and cell-based models, NR boosted brain NAD+ levels in mice, supported cognitive performance and behavior and slowed disease progression in several others. The mechanisms behind these benefits included reduced neuroinflammation, increased levels of BDNF (brain-derived neurotrophic factor) and elevated sirtuin activity. (1,2)

Supports Heart Health. Boosting NAD+ bioavailability with precursors like NR has been proposed as a strategy for supporting cardiovascular health in aging adults. Research showed that adults who took 1,000 mg of NR per day for six weeks had reduced blood pressure. Specifically, people with elevated blood pressure had a reduction in average systolic blood pressure (SBP) after taking NR compared to the placebo. NR had positive effects on risk factors for age-related cardiovascular events, such as aortic stiffness. (3)

Supports Metabolism and Healthy Weight. Although excessive body weight can develop at any age, adults over age 40 are particularly susceptible to age-related weight gain as metabolism slows down and body composition is altered to favor fat over lean muscle. As obese individuals have reductions in both NAD+ levels and ATP (energy) production, replenishing NAD+ through NR can help to reverse this while improving metabolic pathways to maintain a healthy weight. Research shows that supplementing with NR reduces fat mass and increases fat-free mass. (4)


1. Brakedal B, Dölle C, Riemer F, et al. The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson's disease. Cell Metab. 2022;34(3):396-407.e6. doi:10.1016/j.cmet.2022.02.001

2. Nkrumah-Elie Y, Erickson A, Idoine R, et al. Nicotinamide Riboside Supports Brain Health: Assessing the Evidence. Curr Dev Nutr. 2022;6(Suppl 1):798. Published 2022 Jun 14. doi:10.1093/cdn/nzac064.017

3. Martens CR, Denman BA, Mazzo MR, et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nat Commun. 2018;9(1):1286. Published 2018 Mar 29. doi:10.1038/s41467-018-03421-7

4. Remie CME, Roumans KHM, Moonen MPB, et al. Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans. Am J Clin Nutr. 2020;112(2):413-426. doi:10.1093/ajcn/nqaa072

Supplement Facts
Serving Size: 2 Capsules
Servings Per Container: 30
Amount Per Serving %DV
Nicotinamide Riboside Chloride (NIAGEN®) 500 mg
TMG (Trimethylglycine) 250 mg
† Daily Value not established.


PATENT: See Niagen® is a trademark of ChromaDex, Inc.

  • OTHER INGREDIENTS: Microcrystalline cellulose, vegetable capsule.
  • DOES NOT CONTAIN: Dairy, egg, soy, gluten, wheat.
  • SUGGESTED DAILY USE: Take 2 capsules daily, with or without food, or as directed by your healthcare professional.
  • CAUTION: Not intended for use by pregnant or nursing women. Not formulated for use in children. If you have a medical condition or are taking medications, consult with your healthcare professional before using this product.
  • NOTE: Store in a cool, dry place, away from direct sunlight. Do not use if tamper-evident packaging is broken. KEEP OUT OF REACH OF CHILDREN
  • Nicotinamide riboside (NR) is a derivative of the B-vitamin niacin that can improve health and longevity by serving as a precursor to NAD+.
  • This formula also contains 250 mg of TMG (Trimethylglycine), an amino acid that supports the body's methylation processes.
  • NR supplementation has been found to improve various parameters of health, including cardiovascular health, cognition and neurological function, gene expression and healthy body weight.
  • ProHealth’s Nicotinamide Riboside Pro 300 utilizes a patented, clinically-researched form of NR called Niagen®.
  • Clinically-Proven NR.. ProHealth Longevity’s NR uses a clinically-proven form of NR (Niagen®) to boost NAD+ levels.
  • Higher Doses. ProHealth Longevity’s Nicotinamide Riboside Pro 500 contains 500 mg of NR per serving.
  • Combines NR and TMG. When taken as a supplement, NAD+ boosters like NR may require the use of methyl groups to help facilitate the conversion of NAD+ in your cells. Although there is currently no evidence suggesting that NR’s natural methylation process depletes the methyl pool, many top anti-aging experts suggest that safeguarding against methyl depletion may be a wise proactive step to augment your NR intake. TMG, the choice of many of those experts, is an excellent way to help support your body's ability to maintain an adequate methyl pool.
  • Convenient Capsule Form. This NR comes in capsule form, making it easy and convenient to take NR while on the go or traveling.
  • Solvent-Free. Compared to other NR products, ours is made without any chemical solvents.
  • Quality Manufacturing Practices. All of our products are manufactured in an FDA-registered, GMP-certified facility.
  • Third-Party Tested in the USA. Every batch is third-party tested in US laboratories to ensure the highest quality, purity and potency. Certificates of Analysis are available.

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Customer Reviews

Based on 18 reviews
Susan L.
Better bloodwork results

I’ve been taking NRP for four months now and just had the best lab work results my doctor has seen in a long time!

Sadly having unwanted side effects - discontinuing use

I was very excited about the NR Pro, but I experienced the same unwanted side effects I had with my NMN subscription. So I am not taking either NR or NMN any more for now. I'm dissappointed as the research is so promising. Note that this may be just related to me and may not effect others.

Peter H.
Great product

The product arrived quickly and was exactly what I ordered

Norman F.

I definitely feel I have a lot more energy throughout my day. And there’s no mid-afternoon slump. NR Pro 500 is a daily must!

B. K.
NR is great

I have more energy throughout the day. It's a clean feeling of energy, not hyped up.

Raymond M.
Great Product

So happy I can order this product and it's still available!!!

Diane G.
Not for me

I experienced no impact after 2 month use. Experienced better results with [N][M][N]

Adam U.
Great product

Love the pro as it Contains the trans res and tmg all in the same capsules ! Definitely a convenient way to get the most out of nr

Stephanee P.

I like it! Will buy again

Ben F.

Niagen seems to be one of the only types of NR in a form that is shelf stable.

Frequently asked questions

NR performs most of its functions on a cellular level and results are not always outwardly apparent. However, many individuals taking NR report feeling increased energy levels, improved cognitive health, and enhanced exercise performance.
While results may vary based on a variety of factors, NR has been shown to significantly increase NAD+ levels in humans in as little as two weeks.
Research shows that increasing NAD+ levels in aged animals extends their lifespan, but we don’t know for sure if taking supplemental NR does the same in humans.
Clinical research conducted on humans taking NR shows no clinically relevant adverse effects at doses less than 2,000 mg per day.
Research suggests that taking NR may be more effective than taking NAD+ because NR is a smaller molecule that that is more efficiently transported into the cell.