Methylfolate Featuring Quatrefolic - 15 mg, 60 capsules

Folate is a vital B vitamin that plays a key role in methylation—a critical process for DNA synthesis, detoxification, neurotransmitter production, and cardiovascular health. Our formula delivers 5 mg of Quatrefolic®, the most advanced and bioavailable form of folate, designed to bypass genetic polymorphisms (such as MTHFR) that impair folic acid metabolism.*

Why Quatrefolic®?

Quatrefolic® is the glucosamine salt of (6S)-5-methyltetrahydrofolate—the bioactive form of folate that the body uses directly, without requiring conversion. Unlike folic acid, which must go through multiple enzymatic steps to become active, Quatrefolic® is ready for immediate uptake and use at the cellular level.*

• Clinically studied for enhanced bioavailability
• Supports methylation pathways*
• Supports healthy homocysteine balance*
• Supports mood and cardiovascular health*
• Essential for fetal development and reproductive health*

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Who It's For

This high-dose formula is ideal for individuals with increased folate needs or those with MTHFR gene variants who may have trouble converting folic acid to its usable form.*

How It Works

Folate is required to convert homocysteine into methionine—a process vital for cardiovascular and neurological function. It also supports the production of neurotransmitters like serotonin, dopamine, and norepinephrine, which influence mood and cognition.*

What Makes Ours Better?

• Longevity Focused: We leverage cutting-edge advancements in aging research to formulate products that address the fundamental causes of aging.*
• Triple Lab Tested: Every product is tested three times by independent 3rd-party labs to ensure we meet the highest standards.
• Complete Transparency: In an industry flooded with fake supplements, we stand apart by publishing our 3rd-party lab test results. We’re committed to showing you exactly what’s in every bottle, so you can feel confident in what you’re putting into your body. 
• USA Manufacturing Excellence: Made in FDA-regulated, GMP-certified facilities in the USA for the highest quality and safety standards.
• 100-Day Risk-Free Guarantee: We stand behind our products. Not satisfied? Reach out to our Santa Barbara, CA office for a full refund within 100 days – no hassle, no questions.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

References:

¹ Bani Soheila, J Caring Sci 2013 
² Mazza A. et al. Biol Regul Homeost Agents 2016
³ Rima Obeid R., Herrmann W. FEBS Letters 580, 2006
⁴ Stover Patrick, Curr Opin Biotechnol 2017
⁵ Seshadri S. at al. N Engl J Med 2002 
⁶ Bottiglieri T, J Neurol Neurosurg Psychiatry 2000 
⁷ Thaler C.J. 2014 
⁸ Stover PJ. Modern Nutrition in Health and Disease 2012
⁹ Tinelli C, Di Pino A Front. Nutr. 2019