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Calcium AKG Longevity - 1,000 mg per serving, 60 capsules

SKU: PH591

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Support Energy Production, Bone Strength, and Metabolic Function With Age

  • Supports healthy aging processes
  • Supports heart, bone, and metabolic health
  • Supports cognitive vitality
  • Helps to boost antioxidant levels inside cells

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Research-Supported Benefits:

Promotes Metabolic Function and Longevity. Alpha-ketoglutarate (AKG) is a compound that is created naturally in the body but tends to diminish with age. In supplement form, AKG can be attached to a calcium salt (Ca-AKG), which has been studied for its role in supporting metabolic function and longevity. (1)

Stimulates Autophagy. Autophagy, our internal recycling process that removes dysfunctional cells, decreases with age. Ca-AKG has been found to support this process. (2)

Aides in Bone and Muscle Health. Ca-AKG is involved in stimulating protein synthesis and energy production in the body, as it is a vital component of the Krebs cycle - the process that creates ATP (energy) from food. Ca-AKG is also a source of the essential amino acids needed to make collagen, which is a protein that helps to support bone and muscle health. (3)

Supports Blood Sugar Regulation. As we age, our bodies become less efficient at regulating blood sugar. Research shows that Ca-AKG can help to support healthy blood sugar levels. (3)

Supports Cellular Health. The mitochondria, our cells’ main energy hub decreases with age leading to aging and numerous age-related health concerns. Ca-AKG has been found to activate AMPK a pathway that helps maintain cellular energy and support cellular function. (3)

Improves Antioxidant Levels: Ca-AKG has also been shown to boost cellular antioxidant levels in aged mice, which helped support the mice’s blood vessel elasticity - a measure of good cardiovascular health. (4)

References:

1. Asadi Shahmirzadi A, Edgar D, Liao CY, et al. Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice. Cell Metab. 2020;32(3):447-456.e6. doi:10.1016/j.cmet.2020.08.004

2. Chin R, Fu X, Pai M., et al. The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR. Nature. 2014;510:397–40. https://doi.org/10.1038/nature13264

3. Wu N, Yang M, Gaur U, Xu H, Yao Y, Li D. Alpha-Ketoglutarate: Physiological Functions and Applications. Biomol Ther (Seoul). 2016;24(1):1-8. doi:10.4062/biomolther.2015.078

4. Niemiec T, Sikorska J, Harrison A, et al. Alpha-ketoglutarate stabilizes redox homeostasis and improves arterial elasticity in aged mice. J Physiol Pharmacol. 2011;62(1):37-43.

5. Demidenko O, Barardo D, Budovskii V, et al. Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging, after an average of 7 months of use, in the TruAge DNA methylation test. Aging (Albany NY). 2021;13(22):24485-24499. doi:10.18632/aging.203736

6. Wu N, Yang M, Gaur U, Xu H, Yao Y, Li D. Alpha-Ketoglutarate: Physiological Functions and Applications. Biomol Ther (Seoul). 2016;24(1):1-8. doi:10.4062/biomolther.2015.078

7. Wang Y, Deng P, Liu Y, et al. Alpha-ketoglutarate ameliorates age-related osteoporosis via regulating histone methylations. Nat Commun. 2020;11(1):5596. Published 2020 Nov 5. doi:10.1038/s41467-020-19360-

8. Niemiec T, Sikorska J, Harrison A, et al. Alpha-ketoglutarate stabilizes redox homeostasis and improves arterial elasticity in aged mice. J Physiol Pharmacol. 2011;62(1):37-43.

9. Wu N, Yang M, Gaur U, Xu H, Yao Y, Li D. Alpha-Ketoglutarate: Physiological Functions and Applications. Biomol Ther (Seoul). 2016;24(1):1-8. doi:10.4062/biomolther.2015.078

10. Asadi Shahmirzadi A, Edgar D, Liao CY, et al. Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice. Cell Metab. 2020;32(3):447-456.e6. doi:10.1016/j.cmet.2020.08.004

11. Chin R, Fu X, Pai M., et al. The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR. Nature. 2014;510:397–40. https://doi.org/10.1038/nature13264

Supplement Facts
Serving Size: 2 Capsules
Servings Per Container: 30
Amount Per Serving %DV
Calcium Alpha Ketoglutarate 1000 mg
† Daily Value not established
REV.11.21

  • OTHER INGREDIENTS: Vegetable capsule, rice flour.
  • DOES NOT CONTAIN: Dairy, egg, soy, wheat, gluten, corn, sh, shellsh, tree nuts, peanuts.
  • SUGGESTED DAILY USE: Take 2 capsules in the morning, with or without food, or as
    recommended by your healthcare professional.
  • NOTE: Store in a cool, dry place away from direct light. Do not use if tamper-evident
    packaging is broken. KEEP OUT OF REACH OF CHILDREN.
  • CAUTION: Not intended for use if you are pregnant or nursing. Not formulated for use in children. If you have a medical condition or are taking medications, consult with your healthcare professional before using this product.
  • Alpha-ketoglutarate (AKG) is a compound that is created naturally in the body but tends to diminish with age. In supplement form, AKG can be attached to a calcium salt (Ca-AKG), which has been studied for its role in supporting metabolic function and longevity. 6
  • Ca-AKG is involved in stimulating protein synthesis and energy production in the body, as it is a vital component of the Krebs cycle - the process that creates ATP (energy) from food. Ca-AKG is also a source of the essential amino acids needed to make collagen, which is a protein that helps to support bone and muscle health.
  • Ca-AKG facilitates our internal recycling process known as autophagy, which removes dysfunctional cells, cell parts and proteins from the body. Autophagy tends to decrease with age, so Ca-AKG may be able to help support this process.
  • Adding calcium to AKG helps to slow the absorption of AKG allowing it to work longer in the body.
  • Better Absorption. Compared to other products that commonly use unbound AKG or AKG bound to arginine, our AKG is bound to calcium. This combination has been shown to promote extended lifespan and health span in mice, even when administered late in life. It also helps to slow the absorption allowing it to work longer in the body.
  • Research-Supported. Calcium AKG Longevity is formulated using 1,000 mg of calcium alpha ketoglutarate, which has been shown in clinical research to promote longevity by reversing biological age (measured by biological age tests), improve markers of heart health and decrease risk of age-related decline in bone health.
  • Quality Manufacturing Practices. All of our products are manufactured in an FDA-registered, GMP-certified facility.
  • Third-Party Tested in the USA. Every batch is third-party tested in US laboratories to ensure the highest quality, purity and potency. Certificates of Analysis are available.

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Trusted Brand for Calcium AKG

Trusted Brand for Calcium AKG

"This is an awesome product. It has slowed and reversed my graying hair. I am 52 and would usually color my edges every 3 weeks but since using this product (1x every other day) for the last month, I've noticed way less gray coming in and have decided to stop dying my edges. Good quality product!"

- Debbie R., Verified ProHealth Longevity Customer

Customer Reviews

Based on 93 reviews
87%
(81)
11%
(10)
2%
(2)
0%
(0)
0%
(0)
D
Dale
great!!

This is great one for me.

W
William C.
Quality longevity supplements

I’ve been a ProHealth customer for many years. I like that they are constantly offering select products to aid in our journey to stay healthier and minimize the vagaries of aging. Calcium AKG is one such product. The dosing is proper and the science seems promising. I also like their Resveratrol plus botanicals product and their sleep product.

A
Adrian
Health Products

CaAKG its a great quality product!!

R
Ricardo J.
Calcium AKG Longevity.

It’s Awesome.

j
jared s.
Good product

Great

J
Jenny W.
Good product

I like this product, which works for me.

S
Susan E.

Calcium AKG Longevity - 1,000 mg per serving, 60 capsules

G
Glen P.
Calcium AKG Longevity - 1,000 mg

It gives you a nice pump when you’re lifting weights afterwards. Here’s to be a good product

R
Rob W.
toppy produkt

Toppy product, ben er erg blij mee.
Voor een goede gezondheid met mijn 66 jaar.

E
Elias S.

Do not feel anything different yet after 1 month.

Frequently asked questions

Since Ca-AKG does not interfere with circadian rhythm or have stimulant properties, it can be taken any time of day.
Ca-AKG is more stable and is more easily absorbed compared to AKG. Ca-AKG also has a greater effect on collagen formation than AKG that is not bound to calcium.
Ca-AKG can be taken with or without food.
Keep Ca-AKG at room temperature and out of direct sunlight.
Ca-AKG has no known side effects.