Nearly 700 studies from all around the world confirm the remarkable properties of the ancient spice curcumin. It is showing amazing potential for support of the body’s defenses against a wide variety of illnesses including Alzheimer’s, cancer, arthritis, diabetes and multiple sclerosis to name a few.
Curcumin is the primary component of turmeric (Curcuma longa L.) and is what gives the spice its rich yellow color. Native to southern India and Indonesia, turmeric is the star ingredient in curry and is widely used in Indian cuisine.
In addition to its uses as a condiment, food coloring and textile dye, turmeric has been employed in Ayurvedic medicine for more than 4,000 years, utilized for everything from cuts and sores to gastrointestinal pain, rheumatism and liver disorders.
Uncovering the Secrets of Curcumin
About 50 years ago researchers began noticing that many diseases prevalent in Western culture, like Alzheimer’s and multiple sclerosis, were rare in India. Their search to figure out why led them to curcumin. Turmeric – and thereby curcumin – is a staple in every Indian household. Not only do they ingest lots of it in their diet, but they also put it on their bandages to support wound healing(1) and take it orally for many illnesses. In fact, it is so much a part of their culture that brides and grooms apply turmeric and milk to their skin prior to their wedding so they will look more beautiful.
So Western scientists began taking a closer look at curcumin, trying to discover how it works and in what ways it might be used to help various health problems. The result has been more than 2,800 research papers published about the effects of curcumin.
However with all the amazing things curcumin intake is attributed to, there is one key problem – it is very difficult for the human body to absorb. That is why it does not matter how much curcumin you take, but rather how much your body can absorb.
So, in the late 90’s a group of neuroscientists at UCLA began researching how they could make curcumin more bioavailable. Through much trial and error they were able to develop a material they named Longvida. This breakthrough material they created was soluble, permeable and stable, meaning it possessed all of the qualities needed to be bioavailable in the human body.
So What Makes Longvida® Unique?
- More than a dozen research studies and clinical trials in independent labs have been completed on Longvida.
- One small, single daily dose of Longvida offered significant health benefits in just 30 days.
- Published chronic-dosing safety studies on Longvida support a strong safety profile.
- Longvida is 95 times more bioavailable than regular curcumin.
- Longvida offers therapeutic levels of free (not deactivated/metabolized) curcumin.
- Curcumin from Longvida passes the blood-brain barrier.
- Longvida contains no metabolic inhibitors, volatile oils, or crude, unpurified ingredients.
Cutting-edge SLCP™ Technology
SLCP (Solid-Lipid Curcumin Particle) technology is responsible for the ‘magic’ of Longvida®. Longvida® is a finely-tuned matrix of ingredients brought together in a gentle multi-step process.
The end product is precisely set in a way that preserves and protects the curcumin from the harsh environment of the stomach, dissolves it at the point of absorption in the GI tract, and helps the free form of curcumin cross into the bloodstream and target tissues.*
SLCP is the ideal absorption-promoting system, based on real, live research data that was repeated over and over using validated analytical methodologies. Yet all the ingredients are generally recognized as safe (GRAS) food additives, and Longvida® is free of harsh solvents or volatile oils.
Longvida® and Healthy Brain Aging
In a 30 day, randomized placebo-controlled trial, low-dose Longvida (400 mg) in healthy, middle-aged (40-60 year old) people led to sigfigicant improvements versus placebo in the following markers related to cognitive health and healthy brain aging:
- Amyloid-beta 1-42
- Nitric oxide
- Total antioxidant capacity
- Salivary amylase
No adverse events in either group were reported.
“I think what was interesting about this study is that we saw a number of effects, not just one thing,” said Dr. Robert DiSilvestro, Ph.D, Professor at Ohio State and collaborator on the study. “The kinds of effects we saw for the intervention could conceivably help people of different ages and health status.”
Amyloid-beta, Curcumin and Cognitive Function
Circulating levels of amyloid-beta are strongly associated with normal levels of brain deposits, healthy brain aging and cognitive function. Amyloid and other deposits begin to accumulate in the brain more than 20 years before signs of cognitive loss are shown. A decrease in plasma amyloid in healthy individuals may represent a clearance of amyloid from the brain and excretion from the body.
In 30 days, a significant 8% decrease in plasma amyloid-beta was observed in the treatment group, versus no significant change in the placebo group.
Stress and Cognitive Function
Salivary amylase is an established marker for physiological and emotional stress. The impact of stress on healthy aging and cognition is well known (Chida 2008, Kivimaki 2006). Stress and anxiety are also correlated with increased amyloid-beta (Ray 2011).
80mg curcumin from 400mg Longvida significantly reduced salivary amylase, a key marker for physiological stress, in just 30 days.
Lipid Metabolism, Triglycerides and Cognition
Typically, interventions for a short duration as performed in this study in healthy individuals does not significantly impact blood lipids or triglycerides. Plasma triglyceride levels are strongly correlated with plasma amyloid-beta levels in human populations (Fujiwara 2003). Triglyceride levels are also related to healthy brain aging and Alzheimer’s disease (Razay 2007). Elevated plasma triglycerides precede amyloid-beta deposits in Alzheimer’s disease models, suggesting that reduction of triglycerides correlated to a decrease in amyloid-beta and supports healthy brain aging.(Burgess 2006).
30-day dosing of Longvida led to a significant 14% reduction in plasma triglycerides (p<0.05) vs placebo.
Antioxidant Defenses, Catalase and Cognitive Function
Catalase is an antioxidant enzyme that binds with high affinity to amyloid-beta (Milton 1999). Catalase is also responsible for eliminating peroxide radicals, which increase the toxicity of beta-amyloid (Behl 1994). Further, reduced levels of circulating plasma catalase in humans are associated with cognitive impairment, beta-amyloid plaque formation, and Alzheimer’s disease (Torres 2011 ).
30-day dosing of Longvida led to a significant increase in plasma catalase (p<0.05) vs placebo.
Cell Adhesion Molecule SlCam-1 and Cognition
Elevated levels of sICAM -1 are associated with elevated levels of amyloid deposits (Esmaillzadeh 2008). sICAM-1 is strongly associated with dysfunctional endothelial and vascular function. Elevated plasma levels of sICAM-1 have been observed as a possible risk factor for Alzheimer’s and cerebrovascular diseases (Frohman 1991, Nielsen 2007).
30 days dosing of Longvida led to a 14% reduction in sICAM-1 (p<0.05) vs placebo.
Longvida was developed by neuroscientists using a Pharma-Type Research Approach (PTRA). This methodology has been used to answer essential scientific questions to substantiate the efficacy and safety of Longvida.
Just 80mg of curcumin from Longvida supports a number of markers of healthy brain aging in placebo-controlled research. The key message: it is not about how much is consumed, it is about how much is absorbed.
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