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Nattokinase Pro 2000 - 60 capsules

SKU: PH778

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Flow + Flexibility — The Foundation of Vascular Longevity

  • Supports healthy circulation and blood flow*
  • Promotes arterial flexibility and vessel integrity*
  • Enhances nitric oxide signaling and endothelial function*
  • Supports healthy fibrin balance*
  • Helps maintain cholesterol and blood pressure levels already within the normal range*

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Designed for Cardiovascular Longevity

Vascular aging is not about a single pathway. It involves blood flow, arterial structure, endothelial signaling, and calcium balance.

Nattokinase Pro 2000 was built around this principle. We call it the Flow + Flexibility system.

  • Flow refers to healthy circulation and fibrin balance.
  • Flexibility refers to arterial elasticity and proper calcium placement.

This formula combines 2,000 fibrinolytic units of nattokinase with clinically studied polyphenols and long-acting vitamin K2 to support the core biology of vascular aging.*

How It Works

Nattokinase — The Flow Enzyme
Nattokinase is a proteolytic enzyme derived from fermented soybeans, traditionally consumed in Japan as natto. Unlike common dietary enzymes, nattokinase functions systemically. At 2,000 FU per serving, it has been studied for its fibrinolytic activity and its ability to support healthy blood flow.*

Enovita® Grape Seed Extract — Endothelial Support
Standardized to 95 percent total polyphenols, Enovita® has been clinically studied for endothelial function and blood pressure support. It helps enhance nitric oxide signaling, which supports vessel relaxation and elasticity, promotes healthy capillary microcirculation, and provides antioxidant protection to vascular tissue exposed to daily oxidative stress.*

Pine Bark Extract — Nitric Oxide Amplifier
Standardized to 95 percent proanthocyanidins, pine bark extract enhances nitric oxide signaling and supports microcirculation. It also contributes antioxidant defense that helps maintain healthy endothelial structure.*

Pharmaquinone® Vitamin K2 MK-7 — The Flexibility Factor
Vitamin K2 plays a central role in arterial biology. It activates matrix GLA protein, which supports arterial flexibility by helping maintain proper calcium placement. It also activates osteocalcin to support healthy bone structure while helping prevent calcium accumulation in the arteries. MK-7 has a longer half-life compared to other forms of vitamin K, allowing for more sustained activity in the body.*

What Makes Ours Different

  • Systemic Enzyme Activity: Features nattokinase, a proteolytic enzyme studied for systemic fibrinolytic activity that supports whole-body circulation rather than localized digestive effects.*
  • Clinically Aligned Dosing: Delivers 2,000 FU per day, the amount studied for circulation and fibrinolytic support.*
  • Designed for Twice-Daily Use: One capsule twice daily, spaced 8 to 12 hours apart, helps maintain consistent systemic activity over a full 24-hour period.*
  • Multi-Pathway Design: Supports fibrin balance, nitric oxide signaling, arterial flexibility, and antioxidant defense in one coordinated formula.*

The ProHealth Difference

  • Doctor-Formulated: Developed by our in-house science team in collaboration with leading wellness experts.
  • Triple Lab Tested: Verified three times by independent labs for purity and potency.
  • Full Transparency: Third-party test results published online for complete confidence.
  • USA Manufactured: Proudly manufactured in the USA in FDA-registered, GMP-certified facilities since 1988.
  • 100-Day Risk-Free Guarantee: If you’re not fully satisfied, we’ll refund your purchase in full.

A Word from our Chief Science Officer

“Cardiovascular longevity depends on two fundamentals: flow and flexibility. Blood must move efficiently, and vessels must remain responsive and elastic. Nattokinase Pro 2000 was designed to support both sides of that equation, combining a clinically aligned enzyme dose with targeted polyphenols and vitamin K2 to support the architecture of healthy circulation.”

Supplement Facts
Serving Size: 2 Capsules
Servings Per Container: 30
Amount Per Serving %DV
Enovita® Grape (Vitis vinifera) Seed
  Extract (min 95% Total Polyphenols)
200 mg
Pine (Pinus pinaster) Bark Extract
  (min 95% Proanthocyanidins)
150 mg
Nattokinase (2,000 Fibrinolytic Units) 100 mg
Pharmaquinone® Vitamin K2
  (as all trans Menaquinone-7) (MK-7)
90 mcg
† Daily Value (DV) not established.

Enovita® is a trademark owned by Indena SpA,
Italy. Pharmaquinone® is a trademark of VitaSynth Sp. z o.o.d.

REV.01.26

  • OTHER INGREDIENTS: Hypromellose (capsule), rice flour, silica.
  • CONTAINS: Soy
  • SUGGESTED DAILY USE: For best results, take one capsule twice daily, spaced 8 to 12 hours apart, on an empty stomach.
  • CAUTION: Please consult your physician before use if you are pregnant or nursing, under the age of 18, or are undergoing treatment for a medical condition. Do not exceed the suggested use. KEEP OUT OF REACH OF CHILDREN. Store in a cool and dry place.

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Frequently Asked Questions

Nattokinase is a proteolytic enzyme derived from fermented soy. It has been studied for its fibrinolytic activity and its ability to support healthy circulation.*
FU stands for fibrinolytic units, a measure of enzyme activity. This formula delivers 2,000 FU per serving, the amount used in human research for circulatory support.*
Take one capsule twice daily, spaced 8 to 12 hours apart. Many prefer taking it in the morning and evening.
At the studied dose of 2,000 FU per day, nattokinase has been reported as well tolerated in healthy adults. Always consult your healthcare provider if you are on medication or have a medical condition.*
Serratiopeptidase is a systemic proteolytic enzyme often used in inflammation and tissue support formulas. For Nattokinase Pro 2000, we chose to center the formula on a single, clinically studied fibrinolytic enzyme at a research-aligned activity level of 2,000 FU per day.

Nattokinase has human data specifically supporting fibrin activity and healthy circulation, which directly aligns with the Flow component of this formula. By focusing on one well-characterized enzyme, we deliver a defined, evidence-aligned dose with clear mechanism and purpose, rather than combining multiple proteolytic enzymes with overlapping or less targeted effects.*