Reducing salt intake to the recommended daily amount (2300 mg) improved gut health through increased levels of short-chain fatty acids, which are crucial for healthy gut bacteria to thrive.

Diabetes increases the risk of cognitive decline, partly due to reductions in NAD+ levels. NMN boosts NAD+ levels and preserves cognition and brain function in diabetic mice.

Defective T cells speed up aging when defective due to mitochondrial dysfunction, which increases risk of infection. Providing NAD+ or inflammation-suppressing drugs improved health markers in mice.

In older adults, high-resolution fMRI brain scans showed stronger hippocampal activity and replay in the cortex in those who had better memory and recall scores, regardless of age.