Supplemental Urolithin A improved markers of mitophagy and muscle endurance — number of muscle contractions until fatigue for both hand and leg skeletal muscles — in adults age 65-90.
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People with greater increases in the weight and volume of the left ventricle were more likely to have lower midlife cognitive scores on tests of processing speed, executive function, memory, and fluency.
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Older people who scored the highest in terms of how tired or exhausted they would feel after certain activities had more than doubled the risk of mortality in the following 3 years.
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Older mice that did aerobic exercise in late life had epigenetic ages of mice 8 weeks younger than sedentary mice of the same age — reducing epigenetic age by roughly 10% of their lifespan.
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