NMN (nicotinamide mononucleotide) is a derivative of niacin, or vitamin B6. Though niacin is a common dietary supplement, NMN can have a meaningful effect on exercise metabolism and weight loss, at least in mice. The question is, can it do the same in us?

Increased energy is not the only benefit NMN can offer for people with chronic illnesses. It can help improve a number of other health factors, including muscle strength and neurological function.

A new study published in Nature Metabolism has brought to light a new cellular membrane transporter specific to NMN. Encoded by the Slc12a8 gene, it allows NMN to become available inside the cells for direct NAD+ production. 

Because the NAD+ molecule cannot readily cross cell membranes to enter cells,  precursor molecules to NAD+ - such as NMN - must be used to increase bioavailable levels of NAD+.