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The Potential of Magtein®: Magnesium for Cognitive Health and Beyond for Those Over 40

The Potential of Magtein®: Magnesium for Cognitive Health and Beyond for Those Over 40

As our population ages, cognitive health becomes an increasingly personal concern. Magnesium, a vital mineral that regulates myriad bodily functions, has been linked to improved cognition and brain health, with emerging research showing that a particular form of the mineral—Magtein® (Magnesium L-threonate)—demonstrates potential for enhancing cognitive functions in individuals over 40.

What Is Magtein®?

Magtein® is a patented form of magnesium noted scientifically as magnesium L-threonate. Unlike other common forms of magnesium found in supplements—such as magnesium citrate, glycinate, oxide, or chloride—Magtein® has been specially formulated to enhance its ability to cross the blood-brain barrier.

This key difference allows Magtein® to increase magnesium levels directly within the brain, a feat that other forms of magnesium have not been clinically shown to achieve. As a result, Magtein® has been linked with unique cognitive benefits such as improved memory, reduced brain aging, enhanced learning abilities, and stress and anxiety reduction. While all forms of magnesium play essential roles in bodily functions and overall health, Magtein® stands out due to its specific benefits for brain health.

By crossing the blood-brain barrier, Magtein® delivers an array of cognitive benefits, including improved cognitive function, enhanced learning, reduced anxiety and stress, and protection of motor function for those worried about age-related decline in motor control. It was originally developed under a pharmaceutical codename of MMFS-01, though the chemical structure is identical.

Magnesium and Brain Health

Magnesium is instrumental in all of the vital processes that are part of daily life, including mood regulation, memory support, and metabolism. Approximately half of the American population, especially older adults, do not receive sufficient magnesium from their diets. A deficiency in magnesium is connected to decreased cognitive function, one of the main health issues plaguing the aging population.

Part of this is due to limited magnesium in most peoples’ diets. In addition, a large part of the deficiency issue is attributed to the low bioavailability of many magnesium supplements available in the market. This means that, while there may technically be magnesium in a supplement, it’s in a form that’s not available for our cells to use effectively. In response, researchers have developed a compound, magnesium L-threonate, shown to raise magnesium levels in the brain and neurons as well as throughout tissues in the body.

Magtein® and Cognitive Function

Studies indicate significant benefits of Magtein® in supporting cognitive function. A study from 2016 showed that older adults who took between 1.5 and 2 grams of Magtein® per day, depending on their body weight, experienced significantly improved cognitive ability and memory. Moreover, the use of Magtein® led to a reduction of their overall brain age by nine years, as measured by tests of executive function, which include flexible thinking ability, use of working memory, and self-control.

This highlights the potential of Magtein® in preventing cognitive loss, a key issue associated with aging. Furthermore, studies involving animals have shown that Magtein® can increase the number of synapses in the hippocampus, the part of the brain critical for learning and memory.

Magtein® and Mood Regulation 

In addition to cognitive function, Magtein® also plays a role in mood regulation. Magnesium affects the function of neurotransmitters, chemicals made by neurons that transmit messages to other cells. This impact on mood is significant because magnesium's role in neuronal signaling and the production of brain-derived neurotrophic factor (BDNF), a protein that helps neurons survive and grow.

One neurotransmitter affected by magnesium is gamma-aminobutyric acid (GABA), which reduces nervous system activity, leading to feelings of calmness and potentially reducing anxious or stressful feelings.

Magtein® also plays a role in mood regulation.

Magtein® and Healthy Aging 

While we've discussed benefits of Magtein® (magnesium L-threonate) for brain health, there are other potential benefits of this unique form of magnesium, as well as magnesium in general, which can improve overall health and wellbeing as you age. These include benefits for cardiovascular health, bone density, and sleep quality, among others.

Cardiovascular Health

An increasing body of research supports the role of magnesium in maintaining heart health. One significant meta-analysis studied the effects of dietary magnesium intake on cardiovascular health, blood sugar control, and overall lifespan. The research found that higher levels of magnesium intake were associated with improved markers for all of these metrics.

Blood Sugar Management

Magnesium plays a critical role in carbohydrate metabolism and insulin sensitivity. One study concluded that higher magnesium intake was significantly related to a lower risk of damage from chronically elevated blood sugar, especially in the context of low-quality carbohydrate diets.

Bone Health

A study published in The American Journal of Clinical Nutrition found that higher magnesium intake was highly correlated with greater bone mineral density in women. As a bioavailable form of magnesium, Magtein® could potentially contribute to better bone health and fewer fractures in older individuals.

Stable Moods

A study published in a journal for the American Board of Family Medicine reported that adults with lower magnesium intake reported more mood regulation difficulties and had more days where they felt low.

Exercise Performance

A study in Nutrients discovered that a magnesium supplement could enhance exercise performance by decreasing lactate production, which can delay muscle fatigue. Lactate accumulation is what causes the “burn” when you’re exercising, so producing less lactate may help you to work out longer with less discomfort. Remaining active and strong throughout your lifetime is one of the foundational ways to improve your overall health and longevity.

Sleep Quality

Magnesium has been strongly linked to improved sleep quality. A study published in the Journal of Research in Medical Sciences found that magnesium supplementation significantly improved the quality of sleep in the elderly, one of the populations most affected by sleep challenges. This suggests that Magtein®, with its superior bioavailability, could potentially enhance sleep quality for people of every age. 

Magnesium has been strongly linked to improved sleep quality.

Dosage and Consumption

While a recommended daily allowance for magnesium L-threonate has not been established, it is suggested that 1,500 to 2,000 mg per day can bring about cognitive improvements and support healthy sleep patterns. Magtein® is not found naturally in food and is available only in supplement form, such as capsules

Maximizing Cognitive Potential with ProHealth's Brain-Mag Pro

As we age, optimizing brain health becomes an even greater priority. ProHealth's Brain-Mag Pro, containing the patented Magtein® (Magnesium L-threonate), is a scientifically formulated supplement designed specifically to support cognitive health and overall wellness in older adults.

Magtein®, the key ingredient in Brain-Mag Pro, is known for its unique ability to cross the blood-brain barrier, directly elevating magnesium levels in the brain. Unlike other forms of magnesium, Magtein® has been clinically shown to enhance learning abilities, improve memory, reduce brain aging, and help with stress and anxious feelings.

Brain-Mag Pro ensures a bioavailable and effective dose of this unique form of magnesium, making it an ideal choice for those over 40. Supplementation with this product may support enhanced cognitive function, better mood regulation, and a delay in age-associated cognitive decline. Brain-Mag Pro can be a valuable tool for those looking to maintain mental agility and vitality.

But the benefits of Brain-Mag Pro extend beyond cognitive health. As magnesium is a key mineral involved in many bodily processes, consistent supplementation with Brain-Mag Pro may lead to improved overall wellness. Users may experience better sleep quality, increased bone density, more stable mood regulation, improved cardiovascular health, and effective blood sugar management.

ProHealth's Brain-Mag Pro represents a commitment to quality and efficacy, providing a pure and high-quality source of Magtein® to support brain health and general wellbeing. While individual results may vary, users can expect a well-researched and quality-assured supplement to support their cognitive health and aging process. ProHealth is at the forefront of this research, dedicated to helping individuals maintain cognitive health as they age.

Key Takeaways

Magtein® represents an exciting new frontier in the world of magnesium supplementation, offering new hope for those seeking to maintain cognitive health as they age. The benefits of this supplement are manifold and, when taken correctly, it could contribute significantly to improved brain function, better mood, and overall cognitive health.  


  1. Sun Q, Weinger JG, Mao F, Liu G. Regulation of structural and functional synapse density by L-threonate through modulation of intraneuronal magnesium concentration. Neuropharmacology. 2016;108:426-439. doi:10.1016/j.neuropharm.2016.05.006
  2. Slutsky I, Abumaria N, Wu LJ, et al. Enhancement of learning and memory by elevating brain magnesium. Neuron. 2010;65(2):165-177. doi:10.1016/j.neuron.2009.12.026
  3. Liu G, Weinger JG, Lu ZL, Xue F, Sadeghpour S. Efficacy and safety of mmfs-01, a synapse density enhancer, for treating cognitive impairment in older adults: a randomized, double-blind, placebo-controlled trial. J Alz Dis. 2016;49(4):971-990. doi:10.3233/JAD-150538
  4. Fang X, Wang K, Han D, et al. Dietary magnesium intake: a dose-response meta-analysis of prospective cohort studies. BMC Med. 2016;14(1):210. doi:10.1186/s12916-016-0742-z
  5. Kao WH, Folsom AR, Nieto FJ, Mo JP, Watson RL, Brancati FL. Arch Intern Med. 1999;159(18):2151-2159. doi:10.1001/archinte.159.18.2151
  6. Orchard TS, Larson JC, Alghothani N, et al. Magnesium intake, bone mineral density, and fractures: results from the Women’s Health Initiative Observational Study. Am J Clin Nutr. 2014;99(4):926-933. doi:10.3945/ajcn.113.067488
  7. Tarleton EK, Littenberg B. Magnesium intake in adults. J Am Board Fam Med. 2015;28(2):249-256. doi:10.3122/jabfm.2015.02.140176
  8. Nielsen FH, Lukaski HC. Update on the relationship between magnesium and exercise. Magnes Res. 2006;19(3):180-189.
  9. Abbasi B, Kimiagar M, Sadeghniiat K, Shirazi MM, Hedayati M, Rashidkhani B. The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial. J Res Med Sci. 2012;17(12):1161-1169.

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