Pure Fisetin - 250 mg, 60 capsules

SKU: PH632

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Supports and maintains healthy brain function

  • Supports longevity
  • Promotes brain health
  • Enhances cellular health
  • Potent senolytic

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Research-Supported Benefits:

Supports Longevity. Fisetin supports longevity by aiding in the removal of senescent cells from the body. (1) Senescent cells, also known as zombie cells, accumulate as we age and contribute to oxidative stress, inflammation and accelerated cellular aging. Research shows that removing senescent cells extends lifespan in animals. (1)

Promotes Brain Health. Research shows that fisetin supplementation may reduce symptoms of age-related brain health decline. (2) Functioning as an antioxidant to reduce neuroinflammation, fisetin has been shown to enhance learning and memory. (2) Additionally, fisetin may prevent brain cell death associated with brain aging. (2)

Enhances Cellular Health. Oxidative stress contributes to cellular damage and accelerated cellular aging. While inflammation and oxidative stress are natural, high levels of oxidative stress and inflammation dramatically reduce longevity. Research shows that fisetin supplementation may reduce oxidative stress and inflammation due to its antioxidant effects, thus promoting longevity. (3)


1. Yousefzadeh MJ, Zhu Y, McGowan SJ, et al. Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine. 2018;36:18-28. doi:10.1016/j.ebiom.2018.09.015

2. Nabavi SF, Braidy N, Habtemariam S, Sureda A, Manayi A, Nabavi SM. Neuroprotective Effects of Fisetin in Alzheimer's and Parkinson's Diseases: From Chemistry to Medicine. Curr Top Med Chem. 2016;16(17):1910-1915. doi:10.2174/1568026616666160204121725

3. Jiang K, Yang J, Xue G, Dai A, Wu H. Fisetin Ameliorates the Inflammation and Oxidative Stress in Lipopolysaccharide-Induced Endometritis. J Inflamm Res. 2021;14:2963-2978. Published 2021 Jul 5. doi:10.2147/JIR.S314130

  • Fisetin is one of the most potent senolytic compounds in existence. Senolytics are defined as nutrients that aid in the removal of senescent cells from the body. As senescent cells accumulate, oxidative stress and longevity decrease.
  • DNA damage accelerates cellular aging. Fisetin may protect against DNA damage and promote DNA repair.
  • Fisetin exhibits powerful antioxidant effects, reducing oxidative stress and inflammation.
  • As we age, our brain cells degrade due to oxidative stress—the buildup of inflammatory compounds called reactive oxygen species. As an antioxidant, fisetin fights off oxidative stress that damages our cells, including neurons. Fisetin also has exhibited beneficial effects on age-related changes in the brain by triggering signaling pathways that promote brain cell growth and neuronal integrity.
Supplement Facts
Serving Size: 1 Capsule
Servings Per Container: 60
Amount Per Serving %DV
Fisetin (Cotinus coggygria Extract 98%) 250 mg
† Daily Value not established
REV. 12.23
  • OTHER INGREDIENTS: Vegetable capsule, microcrystalline cellulose.
  • DOES NOT CONTAIN: Dairy, egg, soy, wheat, gluten.
  • SUGGESTED DAILY USE: Take 1 capsule daily, with food, or as recommended by your healthcare professional.
  • CAUTION: Not intended for use if you are pregnant or nursing. Not formulated for use in children. If you have a medical condition or are taking medications, consult with your healthcare professional before using this product.
  • NOTE: Store in a cool, dry place, away from direct sunlight. Do not use if tamper-evident packaging is broken. KEEP OUT OF REACH OF CHILDREN
  • Unique Formulation. Pure Fisetin includes only fisetin as the active ingredient, making it the right choice for a targetted senolytic protocol. Our formula is a high-potency, high-purity 98% extraction so you can get the maximum benefit without excess quantities of other compounds.
  • Supported for Daily or Periodic Use. Compared to other fisetin products that are intended to be used 1-2 times per week, our formula is safe enough to be used daily. It can also be pulsed periodically in higher doses.
  • Quality Manufacturing Practices. All of our products are manufactured in an FDA-registered, GMP-certified facility.
  • Third-Party Tested in the USA. Every batch is third-party tested in US laboratories to ensure the highest quality, purity and potency. Certificates of Analysis are available.

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Better Absorption

Better Absorption

"I used a different brand of Fisetin for senolytic therapy that did not give me the results I was expecting. I tried the ProHealth Longevity brand and got much better results. I believe this was because it was more bioavailable (better absorption)."

- John R., Verified ProHealth Longevity Customer

Customer Reviews

Based on 27 reviews
Alla C.

I have been fisetin for years to support senescent cells. This one is the best quality

Garrett T.

Pure Fisetin - 250 mg, 60 capsules

Is it working? Time will tell!

It’s difficult for me to say if my senescent cells are being removed to improve my longevity, but I can say I have had no adverse effects from taking this supplement.

Jongsoo L.
Pure Fisetin - 250mg

I'm 63 years old and this pisetin is just what I need.

Chungnyeong K.

Pure Fisetin - 250 mg, 60 capsules

Chandra D.

Great packaging, clean ingredients and must have to my supplement protocol.

Patrick F.
Pure Fesiten

Excellent product, high quality. I’m on the subscription

Sam W.



Good service and good product!

Prohealth Fisetin

The Fisetin provided by Prohealth is of very good quality, we have had no problems with it, and it has been delivered as ordered.

Frequently asked questions

ProHealth Longevity’s Pure Fisetin is a 98% pure extract of Cotinus coggygria, commonly known as smoketree, to dramatically enhance bioavailability and efficacy. Other products use far lower potency extractions from less sustainable or impure sources.
ProHealth’s Pure Fisetin is formulated to be free of dairy, egg, soy, gluten, wheat or artificial colors or flavors.
Yes. We have created our Pure Fisetin to be compatible with the Mayo Clinic fisetin protocol as it does not include other ingredients that may be consumed in excess with other fisetin supplements. Since this is pure fisetin, it is suitable for this protocol.
Yes, you can take Pure Fisetin daily.